Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Loew 1963 Biochim Biophys Acta

From Bioblast
Publications in the MiPMap
Loew H, Vallin I (1963) Succinate-linked diphosphopyridine nucleotide reduction in submitochondrial particles. Biochim Biophys Acta 69:361-4.

Β» ScienceDirect

Loew H, Vallin I (1963) Biochim Biophys Acta

Abstract:

  1. The reduction of added DPN by succinate catalyzed by submitochondrial particles from beef heart has been studied.
  2. The reduction was endergonic and required specifically the addition of ATP.
  3. The reaction had a limited specificity for electron acceptors; six DPN analogues tested were reduced at the same rate or nearly the same rate, as was DPN. TPN was only reduced at a very slow rate.
  4. The rate of reduction was influenced by phosphate and ADP and their effects became pronounced if added together.
  5. The effect of DPNH was marked only if added in a concentration equal to or exceeding that of DPN.
  6. Respiratory inhibitors acting in the flavin region of the respiratory chain blocked the reaction.

β€’ Keywords: Succinate, DPN, ATP, Beef heart


Labels:


Organism: Bovines  Tissue;cell: Heart  Preparation: Isolated mitochondria  Enzyme: Complex II;succinate dehydrogenase  Regulation: ATP 



Made history