SRot: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr= | |abbr=SRot, CII | ||
|description=''' | |description='''SRot''': '''[[Succinate]]''' (S) supports electron flux through [[Complex II]] via flavin adenine dinucleotide (FADH2) into the membrane-bound [[electron transfer system]]. Inhibition of Complex I by '''[[rotenone]]''' (Rot; or amytal, piericidine) prevents accumulation of [[Oxaloacetate|oxaloacetate]] which is a potent inhibitor of [[succinate dehydrogenase]]. After inhibition of CI by [[rotenone]], the NADH-linked dehydrogenases become inhibited by the redox shift from NAD<sup>+</sup> to NADH. Succinate dehydrogenase is activated by succinate and ATP, which explains in part the time-dependent increase of respiration in isolated mitochondria after addition of rotenone (first), succinate and ADP. | ||
|info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 4.1]] | |info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 4.1]] | ||
}} | }} | ||
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[[File:S(Rot).jpg|400px|thumb|Succinate+rotenone, S(Rot). From [[Gnaiger 2014 MitoPathways]].]] | [[File:S(Rot).jpg|400px|thumb|Succinate+rotenone, S(Rot). From [[Gnaiger 2014 MitoPathways]].]] | ||
== SRot(L) == | |||
# [[MiPNet12.11 MitoRespiration]] | |||
== SRot(P) == | |||
# [[MiPNet12.11 MitoRespiration]] | |||
== SRot(E) == | |||
# [[MiPNet12.11 MitoRespiration]] |
Revision as of 16:30, 24 January 2016
Description
SRot: Succinate (S) supports electron flux through Complex II via flavin adenine dinucleotide (FADH2) into the membrane-bound electron transfer system. Inhibition of Complex I by rotenone (Rot; or amytal, piericidine) prevents accumulation of oxaloacetate which is a potent inhibitor of succinate dehydrogenase. After inhibition of CI by rotenone, the NADH-linked dehydrogenases become inhibited by the redox shift from NAD+ to NADH. Succinate dehydrogenase is activated by succinate and ATP, which explains in part the time-dependent increase of respiration in isolated mitochondria after addition of rotenone (first), succinate and ADP.
Abbreviation: SRot, CII
Reference: Gnaiger 2014 MitoPathways - Chapter 4.1
MitoPedia topics: "Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property. Respiratory substrate-coupling state"Respiratory substrate-coupling state" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
SRot(L)
SRot(P)