Christensen 2016 J Appl Physiol (1985): Difference between revisions
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{{Publication | {{Publication | ||
|title=Christensen PM, Jacobs RA, Bonne T, FlΓΌck D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27. Β | |title=Christensen PM, Jacobs RA, Bonne T, FlΓΌck D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/26846547 PMID: 26846547] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/26846547 PMID: 26846547] | ||
|authors=Christensen PM, Jacobs RA, Bonne T, FlΓΌck D, Bangsbo J, Lundby C | |authors=Christensen PM, Jacobs RA, Bonne T, FlΓΌck D, Bangsbo J, Lundby C | ||
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Copyright Β© 2016 the American Physiological Society. | Copyright Β© 2016 the American Physiological Society. | ||
| | |keywords=OXPHOS, Cycling economy, Enzyme activity, High-intensity training, Oxygen uptake | ||
|mipnetlab=CH Zurich Gassmann M, CH Zurich Lundby C, US CO Colorado Springs Jacobs R | |||
}} | }} | ||
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Revision as of 13:53, 14 September 2016
Christensen PM, Jacobs RA, Bonne T, FlΓΌck D, Bangsbo J, Lundby C (2016) A short period of high-intensity interval training improves skeletal muscle mitochondrial function and pulmonary oxygen uptake kinetics. J Appl Physiol (1985) 120:1319-27. |
Christensen PM, Jacobs RA, Bonne T, FlΓΌck D, Bangsbo J, Lundby C (2016) J Appl Physiol (1985)
Abstract: The aim of the present study was to examine whether improvements in pulmonary oxygen uptake (VΜo2) kinetics following a short period of high-intensity training (HIT) would be associated with improved skeletal muscle mitochondrial function. Ten untrained male volunteers (age 26 Β± 2 yr; mean Β± SD) performed six HIT sessions (8-12 Γ 60 s at incremental test peak power; 271 Β± 52 W) over a 2-wk period. Before and after the HIT period, VΜo2 kinetics was modeled during moderate-intensity cycling (110 Β± 19 W). Mitochondrial function was assessed with high-resolution respirometry (HRR), and maximal activities of oxidative enzymes citrate synthase (CS) and cytochrome c oxidase (COX) were accordingly determined. In response to HIT, VΜo2 kinetics became faster (Ο: 20.4 Β± 4.4 vs. 28.9 Β± 6.1 s; P < 0.01) and fatty acid oxidation (ETFP) and LEAK respiration (LN) both became elevated (P < 0.05). Activity of CS and COX did not increase in response to training. Both before and after the HIT period, fast VΜo2 kinetics (low Ο values) was associated with large values for ETFP, electron transport system capacity (ETS), and electron flow specific to complex II (CIIP) (P < 0.05). Collectively, these findings support that selected measures of mitochondrial function obtained with HRR are important for fast VΜo2 kinetics and better markers than maximal oxidative enzyme activity in describing the speed of the VΜo2 response during moderate-intensity exercise.
Copyright Β© 2016 the American Physiological Society. β’ Keywords: OXPHOS, Cycling economy, Enzyme activity, High-intensity training, Oxygen uptake
β’ O2k-Network Lab: CH Zurich Gassmann M, CH Zurich Lundby C, US CO Colorado Springs Jacobs R
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style
Organism: Human
Coupling state: LEAK
HRR: Oxygraph-2k
Labels, 2016-09, noPDF