Belosludtseva 2020 Bull Exp Biol Med: Difference between revisions
No edit summary |
No edit summary ย |
||
Line 1: | Line 1: | ||
{{Publication | {{Publication | ||
|title=Belosludtseva NV, Talanov EY, Venediktova NI, Sharapov MG, Mironova GD, Belosludtsev KN (2020) Structural and functional features of Ca<sup>2+</sup> transport systems in liver mitochondria of rats with experimental hyperthyroidism. Bull Exp Biol Med | |title=Belosludtseva NV, Talanov EY, Venediktova NI, Sharapov MG, Mironova GD, Belosludtsev KN (2020) Structural and functional features of Ca<sup>2+</sup> transport systems in liver mitochondria of rats with experimental hyperthyroidism. Bull Exp Biol Med 169:224-28. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/32654002 PMID: 32654002] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/32654002 PMID: 32654002] | ||
|authors=Belosludtseva NV, Talanov EY, Venediktova NI, Sharapov MG, Mironova GD, Belosludtsev KN | |authors=Belosludtseva NV, Talanov EY, Venediktova NI, Sharapov MG, Mironova GD, Belosludtsev KN |
Latest revision as of 21:46, 20 August 2020
Belosludtseva NV, Talanov EY, Venediktova NI, Sharapov MG, Mironova GD, Belosludtsev KN (2020) Structural and functional features of Ca2+ transport systems in liver mitochondria of rats with experimental hyperthyroidism. Bull Exp Biol Med 169:224-28. |
Belosludtseva NV, Talanov EY, Venediktova NI, Sharapov MG, Mironova GD, Belosludtsev KN (2020) Bull Exp Biol Med
Abstract: We analyzed structural and functional features of the main mitochondrial Ca2+-transporting systems, mitochondrial Ca2+ uniporter complex (MCUC) and Ca2+-dependent cyclosporin A-sensitive mitochondrial permeability transition pore (MPT pore), in rats with hyperthyroid state. It was found that, the rate of Ca2+ accumulation by rat liver mitochondria in this pathology increases by 1.3 times, which can be associated with higher level of the channel-forming subunit of the uniporter MCU and lower content of dominant-negative subunit of this complex MCUb. At the same time, the level of the regulatory subunit MICU1 remained unchanged. It was shown that calcium retention capacity of liver mitochondria in rats with experimental hyperthyroidism decreased by 2 times in comparison with the control, which attested to reduced resistance of liver mitochondria of hyperthyroid rats to induction of the MPT pore. The observed changes are consistent with the data on increased amount of cyclophilin D, a mitochondrial matrix peptidyl-prolyl isomerase that is known to modulate the MPT pore opening and expression of the Ppif gene that encodes mitochondrial cyclophilin D in rats with experimental hyperthyroidism. โข Keywords: Ca2+-induced mitochondrial permeability transition pore, Cyclophilin D, Hyperthyroidism, Mitochondria, Mitochondrial Ca2+ uniporter โข Bioblast editor: Plangger M โข O2k-Network Lab: RU Pushchino Mironova GD
Labels: MiParea: Respiration
Pathology: Other
Stress:Permeability transition
Organism: Rat
Tissue;cell: Liver
Preparation: Isolated mitochondria
Regulation: Calcium, Ion;substrate transport
HRR: Oxygraph-2k
2020-07