Gnaiger 1994 BTK

Gnaiger E, Gellerich FN, Wyss M (1994) What is Controlling Life? 50 years after Erwin Schrödinger's What is Life? Modern Trends in BiothermoKinetics 3, Innsbruck Univ Press, 336 pp.

» Open Access-BTK 1994

Gnaiger E, Gellerich FN, Wyss M (1994) Innsbruck Univ Press

Abstract: Erwin Schrödinger's 'What is Life?' is one of the most influential books of the last century in the biological sciences. It continues to provoke discussions and stimulate interdisciplinary developments in biophysics. Starting with reflections on Schrödinger's famous account of negative entropy in living systems, an international group of scientists presents the latest advancements on the dynamics and control of metabolic processes. This volume of Modern Trends in BioThermoKinetics develops for the first time the explicit link between thermodynamics, metabolic control, bioenergetics and clinical applications.

• O2k-Network Lab: AT_Innsbruck_Gnaiger E

Labels: MiParea: Respiration, mt-Awareness 

Coupling state: OXPHOS 

HRR: Oxygraph-2k, Theory 

CONTENTS: Full Papers

• OROBOROS Oxygraph applications

Preface

Margreiter R, Innsbruck: p 13.

Gnaiger E, Gellerich FN, Innsbruck

Trends in bioenergetics. An introduction: p 14.

Oberkofler G, Goller P. Innsbruck

"German Ideology" as seen by Erwin Schrödinger in letters to Hans Thirring. From their correspondence (1946-1949): p 19.

Part 1. What is negative entropy? From world views to bioenergetics

Götschl J. Graz

Erwin Schrödinger's world view. The role of physics and biology in his philosophical system: p 23.

Wagensberg J. Barcelona

Science, art and revelation: p 32.

Azzone GF. Padova

Negentropy and historical arrow of time - thermodynamical and informational aspects of the Darwinian revolution: p 38.

Lantos CP. Buenos Aires

Negative entropy: another approach: p 45.

Welch GR. New Orleans

Schrödinger's What is Life?: the biophysical legacy 50 years later: p 48.

Ho MW. London

What is Schrödinger's negentropy? p 50

Gnaiger E. Innsbruck

Negative entropy for living systems. Controversy between Nobel laureates Schrödinger, Pauling and Perutz: p 62. »Bioblast Access

Kushmerick MJ. Seattle

A paradigm for energy balance in muscle function: p 71.

Lloyd D. Cardiff

A controlled chaotic attractor controls life: p 77.

Azzone GF. Padova

Disease as instability, error and entropy: p 81.

Part 2. Control and regulation: theory, models, and experi­ment

Kholodenko BN, Westerhoff HV, Cascante M. Moscow, Amsterdam. Barcelona

The macro- and microworld of control theory: p 88.

Hofmeyr JHS, Cornish-Bowden A. Stellenbosch, Marseille

How should we quantify metabolic regulation? p 91

Westerhoff HV, Jensen PR, Rohwer JM, Kholo­denko BN. Amsterdam, Lyngby, Moscow

Control and regulation: the best of both worlds: p 95.

Heinrich R, Klipp E, Stephani A, Wilhelm T. Berlin

Evolutionary optimization of enzymes on the basis of kinetic and thermodynamic principles: p 99.

Schuster S, Hilgetag C, Fell DA. Berlin, Oxford

Detecting elementary modes of functioning in metabolic networks: p 103.

Part 3. Coupling and mechanisms in the regulation of electron, ATP and ion fluxes

Luvisetto S, Canton M, Schmehl I, Azzone GF. Padova

Leaks and slips during mitochondrial electron trans­fer: p 122.

Brand MD, Chien LF, Diolez PH. Cambridge, Bordeaux

Experimental discrimination between proton leak and redox slip during mitochondrial electron transport: p 125.

Canton M, Luvisetto S, Schmehl I, Azzone GF. Padova

Permeability of the inner mitochondrial membrane and respiration: p 129.

Schmehl I, Canton M, Luvisetto S, Azzone GF. Padova

The uncoupling mechanism of the anesthetic bupivacaine: p 133.

Leverve X, Fontaine E, Espié P, Keriel C, Guérin B, Rigoulet M. Grenoble, Bordeaux

Influence of the mechanism of change in ATP synthase-ATPase. Stoichiometry on the control of oxidative phosphorylation in situ: p 137.

Ouhabi R, Boue-Grabot M, Mazat JP. Bordeaux

ATP synthesis in permeabilized cells: assessment of the ATP/O ratios in situ: p 141.

Fitton V, Ouhabi R, Guérin B, Rigoulet M. Bordeaux

Permeabilized spheroplasts as a tool for studying the mechanistic stoichiometry of yeast oxidative phosphory­la­tion: p 145.

Manon S, Roucou X, Guérin M. Bordeaux

Investigations upon the effect of monovalent cations on oxidative phosphorylation in yeast mitochondria: p 150.

Sparagna G, Gunter KK, Sheu SS, Gunter TE. Rochester

Can mitochondria sequester calcium from physiological calcium pulses? p 154

Ichas F, Jouaville LS , Sidash, SS J.-P. Mazat, E.L. Holmuhamedov. Bordeaux, Pushchino, Kalamazoo

Mitochondrial calcium spiking: the physiological face of permeability transition: p 159.

Dauncey MJ, Clausen T, Harrison AP. Cambridge, Århus

Developmental regulation of Na+,K+- and Ca2+-ATPases in muscle: p 163.

Siegenbeek van Heukelom J et al. Amsterdam, Moscow

What is controlling the cell membrane potential? p 169

Part 4. The microenvironment of mitochondria and cells: diffusion gradients, shuttles and signals

Saks VA, Vasilyeva EV, Khuchua ZA, Belikova YO, Aliev MK, Kesvatera T, Tiivel T, Anflous K, Ventura-Clapier R, Keriel C, Fontaine E, Leverve X. Tallinn, Moscow, Paris, Grenoble

ADP diffusion gradients and metabolic oscillatory signals to mitochondria in heart and liver cells: p 178.

Gellerich FN, Laterveer FD, Gnaiger E, Nicolay K. Utrecht, Innsbruck

Effect of macromolecules on ADP-transport into mitochondria: p 181*. »Bioblast Access

Laterveer FD, Gellerich FN, Gnaiger E, Nicolay K. Utrecht, Innsbruck

Macromolecules increase the channeling of ADP from mitochondrially associated hexokinase to the mitochondrial matrix: p 186*. »Bioblast Access

Méndez G, Gnaiger E. Innsbruck, Buenos Aires

How does oxygen pressure control oxygen flux in isolated mitochondria? A methodological approach by high-resolution respirometry and digital data analysis: p 191*. »Bioblast Access

Soboll S, Conrad A, Gruwel M. Düsseldorf

Determination of creatine kinase fluxes with purified creatine kinase and isolated mitochondria using 31P nuclear magnetic resonance: p 195.

Hoerter JA, Gillet B, Mateo P, Lechene P, Beloeil JC. Chatenay Malabry, Gifs/Yvette

Oscillations of intracellular pH or high energy phosphate content cannot be detected by gated NMR during the cardiac cycle of an isovolumic perfused rat heart: p 199.

Part 5. The impact of bioenergetics on cellular, physiological and biotechnological processes

Gnaiger E, Wyss M. Innsbruck

Chemical forces in the cell: calculations for the ATP system: p 207. »Bioblast Access

Jeneson JAL, Jubrias SA, Kushmerick MJ. Utrecht, Seattle

The flow-force relation of oxidative phosphorylation in human forearm muscle is sigmoidal: p 213.

Mejsnar J, Marsík F. Praha

Muscular contraction, dissipation and Schrödinger's negative entropy: p 215.

Jensen PR, Rohwer JM, Michelsen O, Westerhoff HV. Lyngby, Amsterdam

Modelling of oxidative phosphorylation in E. coli: p 218.

Fishov I. Beer-Sheva

Do oscillations control the bacterial cell cycle? p 221

Kemp RB, Hoare S, Schmalfeldt M, Bridge CMC, Evans PM, Gnaiger E. Aberystwyth, Innsbruck

A thermochemical study of the production of lactate by glutaminolysis and glycolysis in mouse macrophage hybridoma cells: p 226. »Bioblast Access

Larsson C, Nilsson A, Gustafsson L. Göteborg

Catabolic capacity of carbon- or nitrogen-starved cultures of Saccharomyces cerevisiae: p 232.

Krumschnabel G, Wieser W. Innsbruck

Energy allocation and material flux in fish hepatocytes under stress: p 238.

Marx A, de Graaf AA, Wiechert W, Eggeling L, Sahm H. Jülich

Carbon flux in lysine producing strain Corynebacterium glutamicum MH20-22B: analysis by 13C-NMR of amino acids and metabolite balancing: p 240.

Zentgraf B. Furtwangen

• Remarks on biocalorimetry and biothermodynamics aimed at characterization of the physiological state: p 244.

Part 6. The impact of bioenergetics on clinical and pathologi­cal problems

Petronilli V, Nicolli A, Costantini P, Colonna R, Bernardi P. Padova

The permeability transition pore. Pathophysiology of a cyclosporin A-sensitive mitochondrial channel: p 259.

Gellerich FN, Steinlechner R, Wyss M, Eberl T, Müller LC, Skladal D, Sperl W, Dapunt O, Margreiter R, Gnaiger E. Innsbruck

Mitochondrial function in the atrial appendage of the human heart. Characterization by high-resolution respirometry: p 263*. »Bioblast Access

Skladal D, Sperl W, Schranzhofer R, Krismer M, Gnaiger E, Margreiter R, Gellerich FN. Innsbruck

Preservation of mitochondrial functions in human skeletal muscle during storage in high energy preservation solution (HEPS): p 268*. »Bioblast Access

Mazat JP, Letellier T, Malgat M, Jouaville S, Morkuniene R. Bordeaux, Kaunas

Application of control analysis to the study of metabolic diseases in mitochondria. Metabolic expression of mitochondrial DNA mutations: p 272.

Kuznetsov AV, Clark JF, Winkler K, Kunz WS. Magdeburg, Oxford

Change in flux control coefficient of cytochrome c oxidase in copper deficient mottled brindled mice: p 275*. »Bioblast Access

Oexle K, Oberle J, Hübner C

Insulin-dependent diabetes mellitus in MELAS-mitochondriopathy: discussion of possible causal relations: p 278.

Jeneson JAL, Westerhoff HV. Utrecht, Amsterdam

Simulation of the flow-force relation of oxidative phosphor­ylation in Complex I deficiency: p 280.

Steinlechner R, Eberl T, Margreiter R, Gnaiger E. Innsbruck

Oxygen dependence of cellular respiration in endothelial cells: a sensitive toxicological test: p 283*. »Bioblast Access

T. Eberl, R. Steinlechner, W. Salvenmoser, B. Abendstein, M. Rhomberg, Schröcksnadel H, Schmid T, Gnaiger E, Margreiter R. Innsbruck

Endothelial cell cultures as a model for organ preservation studies: p 288*. »Bioblast Access

Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E. Innsbruck

The effect of 2-chlorodeoxyadenosine on endogenous respiration of a human lymphoma cell line (U-937): p 294*. »Bioblast Access

Part 7. Computer software for bioenergetics and metabolic control analysis

Mendes P, Kell DB. Aberystwyth

Simultaneous estimates of single-enzyme kinetic parameters for multi-enzymatic systems using artificial neural networks: p 302.

Wiechert W. Jülich

Design of a software framework for flux determination by 13C NMR isotope labelling experiments: p 305.

Announcements

• Oroboros. Grinzens-Innsbruck, Austria: p 316
• Acknowledgements for Financial Support: p 318

• Index

Subject Index: p 319

Author Index: p 325

Addresses of Participants: p 329