Macleod 2014 Lancet

Macleod MR, Michie S, Roberts I, Dirnagl U, Chalmers I, Ioanidis JPA, Salman RAS, Chan AW, Glasziou P (2014) Biomedicel research: increasing value, reducing waste.. Lancet 383(9912):101-4.

» PMID: 24411643

Macleod MR, Michie S, Roberts I, Dirnagl U, Chalmers I, Ioanidis JPA, Salman RAS, Chan AW, Glasziou P (2014) Lancet

Abstract: Of 1575 reports about cancer prognostic markers pub lished in 2005, 1509 (96%) detailed at least one signifi cant prognostic variable.1

However, few

identifi ed biomarkers have been confi rmed by subsequent research and few have entered routine clinical practice.2

This pattern—initially promising

fi ndings not leading to improvements in health care—has been recorded across biomedical research. So why is research that might transform health care and reduce health problems not being successfully produced?

• Bioblast editor: Iglesias-Gonzalez J

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