Difference between revisions of "MitoEAGLE data: muscle"
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Revision as of 14:57, 27 April 2016
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News and Events |  |
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Working Groups | Short-Term Scientific Missions | Management Committee | Members |  |
COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
Country City Contact Australia Melbourne Bishop David J Austria Innsbruck Laner Verena Austria Innsbruck Gnaiger Erich Austria Salzburg Mayr JA Austria Innsbruck Doerrier Carolina Belgium Leuven Bird Matthew Belgium Liege Votion Dominique-Marie Brazil Jaboticabal, SP Garcia Geovana S Brazil São Paulo Ferreira Julio Cesar B Canada Vancouver Boushel Robert C Canada Edmonton (Alberta) Lemieux Helene Canada Rimouski Blier Pierre U Canada Antigonish Kane Daniel A Canada Rimouski Vandermeeren E Croatia Zagreb Saric A Croatia Split Mihanovic I Czech Republic Pilsen Kuncova J Czech Republic Hradec Králové Waldauf P Czech Republic Prague Elkalaf Moustafa Czech Republic Pilsen Markova Michaela Czech Republic Prague 10 Krajcova Adela Denmark Copenhagen Gonzalez-Franquesa Alba Denmark Malov Hey-Mogensen M Denmark Copenhagen Dela Flemming Denmark Copenhagen N Mortensen OH Denmark Copenhagen Larsen Steen Denmark Hvidovre Nehlin Jan O Estonia Tallinn Puurand Marju Estonia Tallinn Truu Laura Estonia Tallinn Kaambre Tuuli Estonia Tallinn Tepp Kersti Estonia Tallinn Aid-Vanakova Jekaterina Estonia Tallinn Karro N Estonia Tallinn Vendelin Marko Estonia Tartu Paju Kalju Finland Helsinki Pirinen E Finland Jyvaeskylae Lehti Maarit France Paris Armand Anne-Sophie France Paris Petit Patrice X France Bordeaux cedex Mourier A France Grenoble Cedex 9 Schlattner Uwe France Grenoble cedex 9 Dubouchaud Herve France Montpellier Cedex 1 Chabi Beatrice France Paris Ventura-Clapier R France Montpellier Cortade F Germany Köln Kimoloi Sammy Germany Bochum Platen P Germany Düsseldorf Granata Cesare Germany Duesseldorf Roden Michael Germany Duesseldorf Jelenik T Germany Bremerhaven Mark Felix Christopher Germany Leipzig Ost Mario Germany Cologne Pesta Dominik Germany Rostock Haider F Germany Nuthetal Klaus S Germany Munich Jastroch M Greece Heraklio Sidiropoulou K Greece Athens Trougakos Ioannis P Greece Heraklion Tavernarakis Nektarios India Haryana Sharma Vipin Ireland Sligo Murphy J Ireland Dublin O'Gorman Donal Ireland Dublin Porter Richard K Israel Rishon Le Zion Hachmo Yafit Israel Zrifin Sova Marina Israel Jerusalem Saada Reisch Ann Italia Udine Salvadego Desy Italy Milan De Palma Clara Italy Milan Giovarelli Matteo Italy Bologna Genova Maria Luisa Italy Pisa Gastaldelli Amalia Italy Novara Reano Simone Italy Rome Scatena Roberto Japan Sapporo Shirakawa R Japan Sapporo Nambu H Japan Sapporo Maekawa S Latvia Riga Liepins Edgars Latvia Riga Kuka Janis Latvia Riga Zvejniece Liga Latvia Riga Inashkina I Luxembourg Strassen Devaux Yvan Malta Msida Vella Joanna Netherlands Amsterdam De Goede Paul Netherlands BT Amsterdam Jaspers Richard T Netherlands Maastricht Hoeks Joris Netherlands Maastricht Grevendonk L Netherlands Wageningen Keijer Jaap Netherlands Maastricht Van Polanen N Niederlande ER Masstricht De Wit-Verheggen V Niederlande ER Masstricht De Theije C Norway Tromsoe Aasum E Norway Oslo Torp May-Kristin Norway Oslo Nikolic N Norway Tromsoe Jansen Kirsten M Norway Oslo Rustan AC Norway Oslo Eide L Norway Bergen Tronstad Karl Johan Norway Tromsoe Schots Pauke C Norway Tromsoe Larsen Terje S Norway Ullevål Heiestad Christina Norway Oslo Lund Jenny Poland Warsaw Dymkowska Dorota Poland Lodz Watala Cezary Poland Lodz Labieniec-Watala Magdalena Poland Warsaw Sek Aleksandra Poland Warsaw Kampa Rafal Pawel Portugal Coimbra Carvalho Eugenia Portugal Porto Beleza Jorge Portugal Cantanhede Martins Joao D Portugal Coimbra Martins Marques T Portugal Cantanhede Ferreira LL Portugal Porto Coxito Pedro Portugal Coimbra Palmeira Carlos Portugal Porto Magalhaes Jose Portugal Coimbra Pereira Susana P Romania Timisoara Lighezan R Romania Timisoara Muntean Danina M Singapore Singapore Hausenloy Derek J Slovakia Bratislava Nemec Michal Slovakia Bratislava Ukropec J Slovakia Bratislava Sumbalova Zuzana Slovakia Bratislava Ukropcova B Slovakia Bratislava Maderova D Slovenia Ljubljana Mars T Slovenia Ljubljana Pirkmajer Sergej Slovenia Ljubljana Dolinar K South Africa Smith James Spain Barcelona Catalan M Spain Armilla (Granada) Acuna-Castroviejo Dario Spain Barcelona Garcia-Roves Pablo Miguel Spain Barcelona Gama Perez Pau Spain Armilla, Granada Escames Germaine Spain A Coruña Blanco FJ Spain Barcelona Guitart M Spain Granada Lopez Garcia Luis Carlos Spain Madrid Cadenas S Spain Madrid Moran M Spain Barcelona De la Torre Lara J Spain Sevilla Bustos Matilde Spain Barcelona Sebastian D Spain Barcelona Zorzano Antonio Spain Barcelona Batlle M Spain Armilla (Granada) Fernandez-Ortiz Marisol Sweden Stockholm Cardinale Daniele A Sweden Linköping Fontes-Oliveira CC Switzerland Bern Nuoffer Jean-Marc Switzerland Lausanne Morato Fornaguera L Switzerland Lausanne Sandi Carmen Switzerland Lausanne Weger M Switzerland Lausanne Zalachoras I Switzerland Lausanne Gebara E The Netherlands Wageningen Van der Ende Miranda The Netherlands BT Amsterdam Wuest Rob CI Turkey Ankara Tuncay Erkan USA Baltimore Fang Evandro F USA Ann Arbor Beard Daniel A USA Boca Raton Khamoui Andy V USA Orlando Distefano Giovanna USA Baton Rouge Axelrod Christopher L USA Little Rock Porter Craig USA St Louis Welch R USA College Station Latham C USA Gainesville Wohlgemuth Stephanie E USA Gainesville Neyroud D USA Chicago Dayanidhi Sudarshan USA Fairbanks O'Brien Kristin USA Orlando Coen Paul M USA Baton Rouge Irving Brian A USA Baltimore Gonzalez-Freire Marta USA College Station White-Springer Sarah H USA Torrance Rossiter Harry B USA Fort Collins Chicco Adam J USA Colorado Springs Jacobs RA USA Norfolk Lai Nicola USA Gainesville Hepple Russell T USA Seattle Marcinek DJ United Kingdom Oxford Makrecka-Kuka Marina United Kingdom Birmingham Joanisse S United Kingdom Manchester Giakoumaki I United Kingdom Loughborough Ebanks Brad United Kingdom Plymouth, Devon McKenna Helen T United Kingdom London Szabadkai Gyorgy United Kingdom Birmingham Garten Antje United Kingdom Brighton Moore Anthony L United Kingdom Cambridge Shiroma Jonathan G United Kingdom Cambridge Murray Andrew James United Kingdom Birmingham Thakker A United Kingdom Leeds Boyle JP United Kingdom Nottingham Chakrabarti Lisa United Kingdom Birmingham Ashcroft S United States Providence Siamwala J
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap
