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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
Country City Contact Australia Melbourne Bishop David J Austria Innsbruck Gnaiger Erich Austria Salzburg Mayr JA Austria Innsbruck Doerrier Carolina Austria Innsbruck Laner Verena Belgium Leuven Bird Matthew Belgium Liege Votion Dominique-Marie Brazil Jaboticabal, SP Garcia Geovana S Brazil São Paulo Ferreira Julio Cesar B Canada Rimouski Vandermeeren E Canada Antigonish Kane Daniel A Canada Rimouski Blier Pierre U Canada Vancouver Boushel Robert C Canada Edmonton (Alberta) Lemieux Helene Croatia Zagreb Saric A Croatia Split Mihanovic I Czech Republic Prague Elkalaf Moustafa Czech Republic Pilsen Kuncova J Czech Republic Hradec Králové Waldauf P Czech Republic Pilsen Markova Michaela Czech Republic Prague 10 Krajcova Adela Denmark Copenhagen Larsen Steen Denmark Copenhagen N Mortensen OH Denmark Hvidovre Nehlin Jan O Denmark Copenhagen Gonzalez-Franquesa Alba Denmark Malov Hey-Mogensen M Denmark Copenhagen Dela Flemming Estonia Tartu Paju Kalju Estonia Tallinn Kaambre Tuuli Estonia Tallinn Vendelin Marko Estonia Tallinn Tepp Kersti Estonia Tallinn Puurand Marju Estonia Tallinn Truu Laura Estonia Tallinn Aid-Vanakova Jekaterina Estonia Tallinn Karro N Finland Helsinki Pirinen E Finland Jyvaeskylae Lehti Maarit France Grenoble Cedex 9 Schlattner Uwe France Montpellier Cortade F France Paris Armand Anne-Sophie France Montpellier Cedex 1 Chabi Beatrice France Paris Petit Patrice X France Paris Ventura-Clapier R France Grenoble cedex 9 Dubouchaud Herve France Bordeaux cedex Mourier A Germany Rostock Haider F Germany Köln Kimoloi Sammy Germany Cologne Pesta Dominik Germany Nuthetal Klaus S Germany Munich Jastroch M Germany Bochum Platen P Germany Bremerhaven Mark Felix Christopher Germany Düsseldorf Granata Cesare Germany Duesseldorf Jelenik T Germany Duesseldorf Roden Michael Germany Leipzig Ost Mario Greece Heraklio Sidiropoulou K Greece Heraklion Tavernarakis Nektarios Greece Athens Trougakos Ioannis P India Haryana Sharma Vipin Ireland Dublin O'Gorman Donal Ireland Dublin Porter Richard K Ireland Sligo Murphy J Israel Rishon Le Zion Hachmo Yafit Israel Zrifin Sova Marina Israel Jerusalem Saada Reisch Ann Italia Udine Salvadego Desy Italy Rome Scatena Roberto Italy Milan De Palma Clara Italy Pisa Gastaldelli Amalia Italy Novara Reano Simone Italy Milan Giovarelli Matteo Italy Bologna Genova Maria Luisa Japan Sapporo Nambu H Japan Sapporo Maekawa S Japan Sapporo Shirakawa R Latvia Riga Kuka Janis Latvia Riga Liepins Edgars Latvia Riga Zvejniece Liga Latvia Riga Inashkina I Luxembourg Strassen Devaux Yvan Malta Msida Vella Joanna Netherlands Maastricht Van Polanen N Netherlands Wageningen Keijer Jaap Netherlands Amsterdam De Goede Paul Netherlands BT Amsterdam Jaspers Richard T Netherlands Maastricht Grevendonk L Netherlands Maastricht Hoeks Joris Niederlande ER Masstricht De Wit-Verheggen V Niederlande ER Masstricht De Theije C Norway Bergen Tronstad Karl Johan Norway Oslo Lund Jenny Norway Oslo Eide L Norway Oslo Torp May-Kristin Norway Tromsoe Larsen Terje S Norway Tromsoe Jansen Kirsten M Norway Tromsoe Aasum E Norway Oslo Nikolic N Norway Tromsoe Schots Pauke C Norway Oslo Rustan AC Norway Ullevål Heiestad Christina Poland Warsaw Dymkowska Dorota Poland Warsaw Sek Aleksandra Poland Lodz Watala Cezary Poland Warsaw Kampa Rafal Pawel Poland Lodz Labieniec-Watala Magdalena Portugal Coimbra Pereira Susana P Portugal Coimbra Palmeira Carlos Portugal Porto Beleza Jorge Portugal Coimbra Carvalho Eugenia Portugal Cantanhede Martins Joao D Portugal Coimbra Martins Marques T Portugal Cantanhede Ferreira LL Portugal Porto Coxito Pedro Portugal Porto Magalhaes Jose Romania Timisoara Lighezan R Romania Timisoara Muntean Danina M Singapore Singapore Hausenloy Derek J Slovakia Bratislava Ukropcova B Slovakia Bratislava Maderova D Slovakia Bratislava Nemec Michal Slovakia Bratislava Ukropec J Slovakia Bratislava Sumbalova Zuzana Slovenia Ljubljana Pirkmajer Sergej Slovenia Ljubljana Dolinar K Slovenia Ljubljana Mars T South Africa Smith James Spain Madrid Moran M Spain Barcelona Batlle M Spain Armilla (Granada) Fernandez-Ortiz Marisol Spain Barcelona Sebastian D Spain Madrid Cadenas S Spain Barcelona Garcia-Roves Pablo Miguel Spain Barcelona Catalan M Spain Barcelona Zorzano Antonio Spain Barcelona Gama Perez Pau Spain Armilla (Granada) Acuna-Castroviejo Dario Spain A Coruña Blanco FJ Spain Barcelona Guitart M Spain Armilla, Granada Escames Germaine Spain Barcelona De la Torre Lara J Spain Sevilla Bustos Matilde Spain Granada Lopez Garcia Luis Carlos Sweden Stockholm Cardinale Daniele A Sweden Linköping Fontes-Oliveira CC Switzerland Lausanne Gebara E Switzerland Bern Nuoffer Jean-Marc Switzerland Lausanne Morato Fornaguera L Switzerland Lausanne Sandi Carmen Switzerland Lausanne Weger M Switzerland Lausanne Zalachoras I The Netherlands Wageningen Van der Ende Miranda The Netherlands BT Amsterdam Wuest Rob CI Turkey Ankara Tuncay Erkan USA Torrance Rossiter Harry B USA Baton Rouge Irving Brian A USA Fort Collins Chicco Adam J USA Boca Raton Khamoui Andy V USA Baton Rouge Axelrod Christopher L USA Baltimore Fang Evandro F USA Colorado Springs Jacobs RA USA Ann Arbor Beard Daniel A USA Norfolk Lai Nicola USA Gainesville Hepple Russell T USA Chicago Dayanidhi Sudarshan USA Fairbanks O'Brien Kristin USA Orlando Distefano Giovanna USA St Louis Welch R USA Baltimore Gonzalez-Freire Marta USA College Station White-Springer Sarah H USA Gainesville Neyroud D USA College Station Latham C USA Little Rock Porter Craig USA Orlando Coen Paul M USA Gainesville Wohlgemuth Stephanie E United Kingdom Birmingham Garten Antje United Kingdom Birmingham Thakker A United Kingdom Nottingham Chakrabarti Lisa United Kingdom Birmingham Ashcroft S United Kingdom Leeds Boyle JP United Kingdom Oxford Makrecka-Kuka Marina United Kingdom Manchester Giakoumaki I United Kingdom Birmingham Joanisse S United Kingdom Loughborough Ebanks Brad United Kingdom Plymouth, Devon McKenna Helen T United Kingdom Brighton Moore Anthony L United Kingdom Cambridge Shiroma Jonathan G United Kingdom Cambridge Murray Andrew James United Kingdom London Szabadkai Gyorgy United States Providence Siamwala J
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap
