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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
| Country | City | Contact |
|---|---|---|
| Australia | Melbourne | Bishop David J |
| Austria | Innsbruck | Gnaiger Erich |
| Austria | Salzburg | Mayr JA |
| Austria | Innsbruck | Doerrier Carolina |
| Austria | Innsbruck | Laner Verena |
| Belgium | Liege | Votion Dominique-Marie |
| Belgium | Leuven | Bird Matthew |
| Brazil | São Paulo | Ferreira Julio Cesar B |
| Brazil | Jaboticabal, SP | Garcia Geovana S |
| Canada | Vancouver | Boushel Robert C |
| Canada | Edmonton (Alberta) | Lemieux Helene |
| Canada | Rimouski | Blier Pierre U |
| Canada | Antigonish | Kane Daniel A |
| Canada | Rimouski | Vandermeeren E |
| Croatia | Zagreb | Saric A |
| Croatia | Split | Mihanovic I |
| Czech Republic | Hradec Králové | Waldauf P |
| Czech Republic | Pilsen | Markova Michaela |
| Czech Republic | Prague | Elkalaf Moustafa |
| Czech Republic | Prague 10 | Krajcova Adela |
| Czech Republic | Pilsen | Kuncova J |
| Denmark | Copenhagen | Gonzalez-Franquesa Alba |
| Denmark | Malov | Hey-Mogensen M |
| Denmark | Copenhagen | Dela Flemming |
| Denmark | Copenhagen | Larsen Steen |
| Denmark | Copenhagen N | Mortensen OH |
| Denmark | Hvidovre | Nehlin Jan O |
| Estonia | Tallinn | Truu Laura |
| Estonia | Tallinn | Kaambre Tuuli |
| Estonia | Tallinn | Aid-Vanakova Jekaterina |
| Estonia | Tallinn | Vendelin Marko |
| Estonia | Tallinn | Tepp Kersti |
| Estonia | Tallinn | Karro N |
| Estonia | Tartu | Paju Kalju |
| Estonia | Tallinn | Puurand Marju |
| Finland | Jyvaeskylae | Lehti Maarit |
| Finland | Helsinki | Pirinen E |
| France | Paris | Petit Patrice X |
| France | Bordeaux cedex | Mourier A |
| France | Grenoble Cedex 9 | Schlattner Uwe |
| France | Grenoble cedex 9 | Dubouchaud Herve |
| France | Montpellier Cedex 1 | Chabi Beatrice |
| France | Paris | Ventura-Clapier R |
| France | Montpellier | Cortade F |
| France | Paris | Armand Anne-Sophie |
| Germany | Duesseldorf | Roden Michael |
| Germany | Bremerhaven | Mark Felix Christopher |
| Germany | Leipzig | Ost Mario |
| Germany | Rostock | Haider F |
| Germany | Cologne | Pesta Dominik |
| Germany | Nuthetal | Klaus S |
| Germany | Munich | Jastroch M |
| Germany | Bochum | Platen P |
| Germany | Köln | Kimoloi Sammy |
| Germany | Düsseldorf | Granata Cesare |
| Germany | Duesseldorf | Jelenik T |
| Greece | Heraklio | Sidiropoulou K |
| Greece | Athens | Trougakos Ioannis P |
| Greece | Heraklion | Tavernarakis Nektarios |
| India | Haryana | Sharma Vipin |
| Ireland | Dublin | O'Gorman Donal |
| Ireland | Dublin | Porter Richard K |
| Ireland | Sligo | Murphy J |
| Israel | Zrifin | Sova Marina |
| Israel | Jerusalem | Saada Reisch Ann |
| Israel | Rishon Le Zion | Hachmo Yafit |
| Italia | Udine | Salvadego Desy |
| Italy | Milan | Giovarelli Matteo |
| Italy | Bologna | Genova Maria Luisa |
| Italy | Pisa | Gastaldelli Amalia |
| Italy | Novara | Reano Simone |
| Italy | Rome | Scatena Roberto |
| Italy | Milan | De Palma Clara |
| Japan | Sapporo | Shirakawa R |
| Japan | Sapporo | Nambu H |
| Japan | Sapporo | Maekawa S |
| Latvia | Riga | Kuka Janis |
| Latvia | Riga | Zvejniece Liga |
| Latvia | Riga | Inashkina I |
| Latvia | Riga | Liepins Edgars |
| Luxembourg | Strassen | Devaux Yvan |
| Malta | Msida | Vella Joanna |
| Netherlands | BT Amsterdam | Jaspers Richard T |
| Netherlands | Maastricht | Grevendonk L |
| Netherlands | Maastricht | Hoeks Joris |
| Netherlands | Maastricht | Van Polanen N |
| Netherlands | Wageningen | Keijer Jaap |
| Netherlands | Amsterdam | De Goede Paul |
| Niederlande | ER Masstricht | De Theije C |
| Niederlande | ER Masstricht | De Wit-Verheggen V |
| Norway | Oslo | Nikolic N |
| Norway | Tromsoe | Jansen Kirsten M |
| Norway | Oslo | Rustan AC |
| Norway | Bergen | Tronstad Karl Johan |
| Norway | Oslo | Eide L |
| Norway | Tromsoe | Schots Pauke C |
| Norway | Ullevål | Heiestad Christina |
| Norway | Tromsoe | Larsen Terje S |
| Norway | Oslo | Lund Jenny |
| Norway | Tromsoe | Aasum E |
| Norway | Oslo | Torp May-Kristin |
| Poland | Lodz | Watala Cezary |
| Poland | Lodz | Labieniec-Watala Magdalena |
| Poland | Warsaw | Sek Aleksandra |
| Poland | Warsaw | Kampa Rafal Pawel |
| Poland | Warsaw | Dymkowska Dorota |
| Portugal | Porto | Beleza Jorge |
| Portugal | Cantanhede | Martins Joao D |
| Portugal | Cantanhede | Ferreira LL |
| Portugal | Coimbra | Martins Marques T |
| Portugal | Coimbra | Palmeira Carlos |
| Portugal | Porto | Coxito Pedro |
| Portugal | Porto | Magalhaes Jose |
| Portugal | Coimbra | Pereira Susana P |
| Portugal | Coimbra | Carvalho Eugenia |
| Romania | Timisoara | Lighezan R |
| Romania | Timisoara | Muntean Danina M |
| Singapore | Singapore | Hausenloy Derek J |
| Slovakia | Bratislava | Sumbalova Zuzana |
| Slovakia | Bratislava | Ukropcova B |
| Slovakia | Bratislava | Maderova D |
| Slovakia | Bratislava | Nemec Michal |
| Slovakia | Bratislava | Ukropec J |
| Slovenia | Ljubljana | Pirkmajer Sergej |
| Slovenia | Ljubljana | Dolinar K |
| Slovenia | Ljubljana | Mars T |
| South Africa | Smith James | |
| Spain | Barcelona | Gama Perez Pau |
| Spain | Armilla (Granada) | Acuna-Castroviejo Dario |
| Spain | A Coruña | Blanco FJ |
| Spain | Barcelona | Garcia-Roves Pablo Miguel |
| Spain | Barcelona | Guitart M |
| Spain | Armilla, Granada | Escames Germaine |
| Spain | Granada | Lopez Garcia Luis Carlos |
| Spain | Madrid | Moran M |
| Spain | Barcelona | Sebastian D |
| Spain | Madrid | Cadenas S |
| Spain | Barcelona | De la Torre Lara J |
| Spain | Sevilla | Bustos Matilde |
| Spain | Barcelona | Catalan M |
| Spain | Barcelona | Batlle M |
| Spain | Armilla (Granada) | Fernandez-Ortiz Marisol |
| Spain | Barcelona | Zorzano Antonio |
| Sweden | Linköping | Fontes-Oliveira CC |
| Sweden | Stockholm | Cardinale Daniele A |
| Switzerland | Bern | Nuoffer Jean-Marc |
| Switzerland | Lausanne | Sandi Carmen |
| Switzerland | Lausanne | Weger M |
| Switzerland | Lausanne | Zalachoras I |
| Switzerland | Lausanne | Gebara E |
| Switzerland | Lausanne | Morato Fornaguera L |
| The Netherlands | Wageningen | Van der Ende Miranda |
| The Netherlands | BT Amsterdam | Wuest Rob CI |
| Turkey | Ankara | Tuncay Erkan |
| USA | Orlando | Distefano Giovanna |
| USA | St Louis | Welch R |
| USA | Baton Rouge | Axelrod Christopher L |
| USA | Gainesville | Neyroud D |
| USA | College Station | Latham C |
| USA | Little Rock | Porter Craig |
| USA | Chicago | Dayanidhi Sudarshan |
| USA | Orlando | Coen Paul M |
| USA | Gainesville | Wohlgemuth Stephanie E |
| USA | Fairbanks | O'Brien Kristin |
| USA | Torrance | Rossiter Harry B |
| USA | Baltimore | Gonzalez-Freire Marta |
| USA | College Station | White-Springer Sarah H |
| USA | Baton Rouge | Irving Brian A |
| USA | Fort Collins | Chicco Adam J |
| USA | Baltimore | Fang Evandro F |
| USA | Colorado Springs | Jacobs RA |
| USA | Ann Arbor | Beard Daniel A |
| USA | Norfolk | Lai Nicola |
| USA | Gainesville | Hepple Russell T |
| USA | Boca Raton | Khamoui Andy V |
| United Kingdom | Manchester | Giakoumaki I |
| United Kingdom | London | Szabadkai Gyorgy |
| United Kingdom | Loughborough | Ebanks Brad |
| United Kingdom | Plymouth, Devon | McKenna Helen T |
| United Kingdom | Birmingham | Garten Antje |
| United Kingdom | Birmingham | Thakker A |
| United Kingdom | Cambridge | Shiroma Jonathan G |
| United Kingdom | Brighton | Moore Anthony L |
| United Kingdom | Nottingham | Chakrabarti Lisa |
| United Kingdom | Cambridge | Murray Andrew James |
| United Kingdom | Birmingham | Ashcroft S |
| United Kingdom | Leeds | Boyle JP |
| United Kingdom | Oxford | Makrecka-Kuka Marina |
| United Kingdom | Birmingham | Joanisse S |
| United States | Providence | Siamwala J |
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap
