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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
Country City Contact Australia Melbourne Bishop David J Austria Salzburg Mayr JA Austria Innsbruck Doerrier Carolina Austria Innsbruck Laner Verena Austria Innsbruck Gnaiger Erich Belgium Liege Votion Dominique-Marie Belgium Leuven Bird Matthew Brazil São Paulo Ferreira Julio Cesar B Brazil Jaboticabal, SP Garcia Geovana S Canada Rimouski Blier Pierre U Canada Antigonish Kane Daniel A Canada Rimouski Vandermeeren E Canada Vancouver Boushel Robert C Canada Edmonton (Alberta) Lemieux Helene Croatia Zagreb Saric A Croatia Split Mihanovic I Czech Republic Pilsen Kuncova J Czech Republic Hradec Králové Waldauf P Czech Republic Pilsen Markova Michaela Czech Republic Prague 10 Krajcova Adela Czech Republic Prague Elkalaf Moustafa Denmark Hvidovre Nehlin Jan O Denmark Copenhagen Gonzalez-Franquesa Alba Denmark Malov Hey-Mogensen M Denmark Copenhagen Dela Flemming Denmark Copenhagen N Mortensen OH Denmark Copenhagen Larsen Steen Estonia Tallinn Vendelin Marko Estonia Tallinn Tepp Kersti Estonia Tallinn Aid-Vanakova Jekaterina Estonia Tallinn Karro N Estonia Tallinn Puurand Marju Estonia Tartu Paju Kalju Estonia Tallinn Truu Laura Estonia Tallinn Kaambre Tuuli Finland Helsinki Pirinen E Finland Jyvaeskylae Lehti Maarit France Montpellier Cedex 1 Chabi Beatrice France Paris Ventura-Clapier R France Grenoble cedex 9 Dubouchaud Herve France Montpellier Cortade F France Paris Armand Anne-Sophie France Paris Petit Patrice X France Bordeaux cedex Mourier A France Grenoble Cedex 9 Schlattner Uwe Germany Cologne Pesta Dominik Germany Nuthetal Klaus S Germany Munich Jastroch M Germany Bochum Platen P Germany Düsseldorf Granata Cesare Germany Duesseldorf Jelenik T Germany Duesseldorf Roden Michael Germany Köln Kimoloi Sammy Germany Leipzig Ost Mario Germany Bremerhaven Mark Felix Christopher Germany Rostock Haider F Greece Heraklion Tavernarakis Nektarios Greece Heraklio Sidiropoulou K Greece Athens Trougakos Ioannis P India Haryana Sharma Vipin Ireland Dublin O'Gorman Donal Ireland Dublin Porter Richard K Ireland Sligo Murphy J Israel Rishon Le Zion Hachmo Yafit Israel Zrifin Sova Marina Israel Jerusalem Saada Reisch Ann Italia Udine Salvadego Desy Italy Pisa Gastaldelli Amalia Italy Rome Scatena Roberto Italy Novara Reano Simone Italy Milan De Palma Clara Italy Milan Giovarelli Matteo Italy Bologna Genova Maria Luisa Japan Sapporo Maekawa S Japan Sapporo Shirakawa R Japan Sapporo Nambu H Latvia Riga Zvejniece Liga Latvia Riga Inashkina I Latvia Riga Liepins Edgars Latvia Riga Kuka Janis Luxembourg Strassen Devaux Yvan Malta Msida Vella Joanna Netherlands Wageningen Keijer Jaap Netherlands Amsterdam De Goede Paul Netherlands Maastricht Grevendonk L Netherlands Maastricht Hoeks Joris Netherlands Maastricht Van Polanen N Netherlands BT Amsterdam Jaspers Richard T Niederlande ER Masstricht De Wit-Verheggen V Niederlande ER Masstricht De Theije C Norway Oslo Eide L Norway Tromsoe Larsen Terje S Norway Tromsoe Schots Pauke C Norway Tromsoe Aasum E Norway Ullevål Heiestad Christina Norway Oslo Lund Jenny Norway Oslo Nikolic N Norway Oslo Torp May-Kristin Norway Oslo Rustan AC Norway Tromsoe Jansen Kirsten M Norway Bergen Tronstad Karl Johan Poland Warsaw Sek Aleksandra Poland Warsaw Kampa Rafal Pawel Poland Warsaw Dymkowska Dorota Poland Lodz Watala Cezary Poland Lodz Labieniec-Watala Magdalena Portugal Coimbra Palmeira Carlos Portugal Cantanhede Ferreira LL Portugal Coimbra Martins Marques T Portugal Porto Coxito Pedro Portugal Coimbra Carvalho Eugenia Portugal Porto Magalhaes Jose Portugal Coimbra Pereira Susana P Portugal Porto Beleza Jorge Portugal Cantanhede Martins Joao D Romania Timisoara Muntean Danina M Romania Timisoara Lighezan R Singapore Singapore Hausenloy Derek J Slovakia Bratislava Maderova D Slovakia Bratislava Nemec Michal Slovakia Bratislava Ukropec J Slovakia Bratislava Sumbalova Zuzana Slovakia Bratislava Ukropcova B Slovenia Ljubljana Pirkmajer Sergej Slovenia Ljubljana Dolinar K Slovenia Ljubljana Mars T South Africa Smith James Spain Barcelona Sebastian D Spain Madrid Cadenas S Spain Barcelona Catalan M Spain Barcelona De la Torre Lara J Spain Sevilla Bustos Matilde Spain Barcelona Zorzano Antonio Spain Barcelona Batlle M Spain Barcelona Gama Perez Pau Spain Armilla (Granada) Fernandez-Ortiz Marisol Spain Armilla (Granada) Acuna-Castroviejo Dario Spain A Coruña Blanco FJ Spain Barcelona Guitart M Spain Armilla, Granada Escames Germaine Spain Barcelona Garcia-Roves Pablo Miguel Spain Granada Lopez Garcia Luis Carlos Spain Madrid Moran M Sweden Linköping Fontes-Oliveira CC Sweden Stockholm Cardinale Daniele A Switzerland Lausanne Gebara E Switzerland Lausanne Morato Fornaguera L Switzerland Lausanne Sandi Carmen Switzerland Lausanne Weger M Switzerland Bern Nuoffer Jean-Marc Switzerland Lausanne Zalachoras I The Netherlands Wageningen Van der Ende Miranda The Netherlands BT Amsterdam Wuest Rob CI Turkey Ankara Tuncay Erkan USA Fairbanks O'Brien Kristin USA Baltimore Gonzalez-Freire Marta USA College Station White-Springer Sarah H USA Colorado Springs Jacobs RA USA Baltimore Fang Evandro F USA Norfolk Lai Nicola USA Ann Arbor Beard Daniel A USA Gainesville Hepple Russell T USA Orlando Distefano Giovanna USA St Louis Welch R USA Gainesville Neyroud D USA College Station Latham C USA Boca Raton Khamoui Andy V USA Little Rock Porter Craig USA Gainesville Wohlgemuth Stephanie E USA Baton Rouge Axelrod Christopher L USA Orlando Coen Paul M USA Torrance Rossiter Harry B USA Baton Rouge Irving Brian A USA Fort Collins Chicco Adam J USA Chicago Dayanidhi Sudarshan United Kingdom Birmingham Thakker A United Kingdom Birmingham Garten Antje United Kingdom Loughborough Ebanks Brad United Kingdom Plymouth, Devon McKenna Helen T United Kingdom Nottingham Chakrabarti Lisa United Kingdom Birmingham Ashcroft S United Kingdom Leeds Boyle JP United Kingdom Oxford Makrecka-Kuka Marina United Kingdom Cambridge Shiroma Jonathan G United Kingdom Brighton Moore Anthony L United Kingdom Cambridge Murray Andrew James United Kingdom Birmingham Joanisse S United Kingdom London Szabadkai Gyorgy United Kingdom Manchester Giakoumaki I United States Providence Siamwala J
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap