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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
Country | City | Contact |
---|---|---|
Australia | Melbourne | Bishop David J |
Austria | Innsbruck | Laner Verena |
Austria | Innsbruck | Gnaiger Erich |
Austria | Salzburg | Mayr JA |
Austria | Innsbruck | Doerrier Carolina |
Belgium | Leuven | Bird Matthew |
Belgium | Liege | Votion Dominique-Marie |
Brazil | São Paulo | Ferreira Julio Cesar B |
Brazil | Jaboticabal, SP | Garcia Geovana S |
Canada | Rimouski | Blier Pierre U |
Canada | Vancouver | Boushel Robert C |
Canada | Edmonton (Alberta) | Lemieux Helene |
Canada | Rimouski | Vandermeeren E |
Canada | Antigonish | Kane Daniel A |
Croatia | Zagreb | Saric A |
Croatia | Split | Mihanovic I |
Czech Republic | Hradec Králové | Waldauf P |
Czech Republic | Pilsen | Markova Michaela |
Czech Republic | Prague 10 | Krajcova Adela |
Czech Republic | Prague | Elkalaf Moustafa |
Czech Republic | Pilsen | Kuncova J |
Denmark | Copenhagen | Gonzalez-Franquesa Alba |
Denmark | Malov | Hey-Mogensen M |
Denmark | Copenhagen | Dela Flemming |
Denmark | Copenhagen | Larsen Steen |
Denmark | Copenhagen N | Mortensen OH |
Denmark | Hvidovre | Nehlin Jan O |
Estonia | Tallinn | Puurand Marju |
Estonia | Tallinn | Aid-Vanakova Jekaterina |
Estonia | Tallinn | Truu Laura |
Estonia | Tallinn | Karro N |
Estonia | Tartu | Paju Kalju |
Estonia | Tallinn | Kaambre Tuuli |
Estonia | Tallinn | Vendelin Marko |
Estonia | Tallinn | Tepp Kersti |
Finland | Jyvaeskylae | Lehti Maarit |
Finland | Helsinki | Pirinen E |
France | Grenoble cedex 9 | Dubouchaud Herve |
France | Bordeaux cedex | Mourier A |
France | Grenoble Cedex 9 | Schlattner Uwe |
France | Montpellier | Cortade F |
France | Paris | Armand Anne-Sophie |
France | Montpellier Cedex 1 | Chabi Beatrice |
France | Paris | Petit Patrice X |
France | Paris | Ventura-Clapier R |
Germany | Duesseldorf | Jelenik T |
Germany | Duesseldorf | Roden Michael |
Germany | Leipzig | Ost Mario |
Germany | Rostock | Haider F |
Germany | Cologne | Pesta Dominik |
Germany | Köln | Kimoloi Sammy |
Germany | Nuthetal | Klaus S |
Germany | Munich | Jastroch M |
Germany | Bochum | Platen P |
Germany | Bremerhaven | Mark Felix Christopher |
Germany | Düsseldorf | Granata Cesare |
Greece | Heraklion | Tavernarakis Nektarios |
Greece | Heraklio | Sidiropoulou K |
Greece | Athens | Trougakos Ioannis P |
India | Haryana | Sharma Vipin |
Ireland | Sligo | Murphy J |
Ireland | Dublin | O'Gorman Donal |
Ireland | Dublin | Porter Richard K |
Israel | Rishon Le Zion | Hachmo Yafit |
Israel | Zrifin | Sova Marina |
Israel | Jerusalem | Saada Reisch Ann |
Italia | Udine | Salvadego Desy |
Italy | Milan | De Palma Clara |
Italy | Pisa | Gastaldelli Amalia |
Italy | Milan | Giovarelli Matteo |
Italy | Novara | Reano Simone |
Italy | Bologna | Genova Maria Luisa |
Italy | Rome | Scatena Roberto |
Japan | Sapporo | Shirakawa R |
Japan | Sapporo | Nambu H |
Japan | Sapporo | Maekawa S |
Latvia | Riga | Liepins Edgars |
Latvia | Riga | Zvejniece Liga |
Latvia | Riga | Inashkina I |
Latvia | Riga | Kuka Janis |
Luxembourg | Strassen | Devaux Yvan |
Malta | Msida | Vella Joanna |
Netherlands | Maastricht | Grevendonk L |
Netherlands | Maastricht | Hoeks Joris |
Netherlands | Maastricht | Van Polanen N |
Netherlands | Wageningen | Keijer Jaap |
Netherlands | Amsterdam | De Goede Paul |
Netherlands | BT Amsterdam | Jaspers Richard T |
Niederlande | ER Masstricht | De Theije C |
Niederlande | ER Masstricht | De Wit-Verheggen V |
Norway | Oslo | Nikolic N |
Norway | Tromsoe | Schots Pauke C |
Norway | Oslo | Rustan AC |
Norway | Ullevål | Heiestad Christina |
Norway | Bergen | Tronstad Karl Johan |
Norway | Oslo | Lund Jenny |
Norway | Oslo | Eide L |
Norway | Oslo | Torp May-Kristin |
Norway | Tromsoe | Larsen Terje S |
Norway | Tromsoe | Jansen Kirsten M |
Norway | Tromsoe | Aasum E |
Poland | Warsaw | Dymkowska Dorota |
Poland | Lodz | Watala Cezary |
Poland | Warsaw | Sek Aleksandra |
Poland | Warsaw | Kampa Rafal Pawel |
Poland | Lodz | Labieniec-Watala Magdalena |
Portugal | Coimbra | Martins Marques T |
Portugal | Cantanhede | Ferreira LL |
Portugal | Porto | Coxito Pedro |
Portugal | Porto | Magalhaes Jose |
Portugal | Coimbra | Pereira Susana P |
Portugal | Coimbra | Palmeira Carlos |
Portugal | Porto | Beleza Jorge |
Portugal | Coimbra | Carvalho Eugenia |
Portugal | Cantanhede | Martins Joao D |
Romania | Timisoara | Lighezan R |
Romania | Timisoara | Muntean Danina M |
Singapore | Singapore | Hausenloy Derek J |
Slovakia | Bratislava | Sumbalova Zuzana |
Slovakia | Bratislava | Ukropcova B |
Slovakia | Bratislava | Maderova D |
Slovakia | Bratislava | Nemec Michal |
Slovakia | Bratislava | Ukropec J |
Slovenia | Ljubljana | Pirkmajer Sergej |
Slovenia | Ljubljana | Dolinar K |
Slovenia | Ljubljana | Mars T |
South Africa | Smith James | |
Spain | Armilla (Granada) | Acuna-Castroviejo Dario |
Spain | Barcelona | Gama Perez Pau |
Spain | A Coruña | Blanco FJ |
Spain | Barcelona | Guitart M |
Spain | Armilla, Granada | Escames Germaine |
Spain | Barcelona | De la Torre Lara J |
Spain | Sevilla | Bustos Matilde |
Spain | Granada | Lopez Garcia Luis Carlos |
Spain | Barcelona | Batlle M |
Spain | Armilla (Granada) | Fernandez-Ortiz Marisol |
Spain | Madrid | Moran M |
Spain | Madrid | Cadenas S |
Spain | Barcelona | Sebastian D |
Spain | Barcelona | Garcia-Roves Pablo Miguel |
Spain | Barcelona | Catalan M |
Spain | Barcelona | Zorzano Antonio |
Sweden | Stockholm | Cardinale Daniele A |
Sweden | Linköping | Fontes-Oliveira CC |
Switzerland | Lausanne | Morato Fornaguera L |
Switzerland | Lausanne | Sandi Carmen |
Switzerland | Lausanne | Weger M |
Switzerland | Lausanne | Zalachoras I |
Switzerland | Lausanne | Gebara E |
Switzerland | Bern | Nuoffer Jean-Marc |
The Netherlands | Wageningen | Van der Ende Miranda |
The Netherlands | BT Amsterdam | Wuest Rob CI |
Turkey | Ankara | Tuncay Erkan |
USA | Fairbanks | O'Brien Kristin |
USA | Orlando | Distefano Giovanna |
USA | St Louis | Welch R |
USA | Baltimore | Gonzalez-Freire Marta |
USA | College Station | White-Springer Sarah H |
USA | Gainesville | Neyroud D |
USA | College Station | Latham C |
USA | Little Rock | Porter Craig |
USA | Gainesville | Wohlgemuth Stephanie E |
USA | Orlando | Coen Paul M |
USA | Torrance | Rossiter Harry B |
USA | Baton Rouge | Irving Brian A |
USA | Fort Collins | Chicco Adam J |
USA | Boca Raton | Khamoui Andy V |
USA | Baton Rouge | Axelrod Christopher L |
USA | Baltimore | Fang Evandro F |
USA | Colorado Springs | Jacobs RA |
USA | Ann Arbor | Beard Daniel A |
USA | Norfolk | Lai Nicola |
USA | Gainesville | Hepple Russell T |
USA | Chicago | Dayanidhi Sudarshan |
United Kingdom | Loughborough | Ebanks Brad |
United Kingdom | Plymouth, Devon | McKenna Helen T |
United Kingdom | Brighton | Moore Anthony L |
United Kingdom | Cambridge | Shiroma Jonathan G |
United Kingdom | Cambridge | Murray Andrew James |
United Kingdom | London | Szabadkai Gyorgy |
United Kingdom | Birmingham | Thakker A |
United Kingdom | Birmingham | Garten Antje |
United Kingdom | Nottingham | Chakrabarti Lisa |
United Kingdom | Birmingham | Ashcroft S |
United Kingdom | Leeds | Boyle JP |
United Kingdom | Oxford | Makrecka-Kuka Marina |
United Kingdom | Manchester | Giakoumaki I |
United Kingdom | Birmingham | Joanisse S |
United States | Providence | Siamwala J |
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap