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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
Country City Contact Australia Melbourne Bishop David J Austria Innsbruck Gnaiger Erich Austria Salzburg Mayr JA Austria Innsbruck Doerrier Carolina Austria Innsbruck Laner Verena Belgium Liege Votion Dominique-Marie Belgium Leuven Bird Matthew Brazil São Paulo Ferreira Julio Cesar B Brazil Jaboticabal, SP Garcia Geovana S Canada Vancouver Boushel Robert C Canada Edmonton (Alberta) Lemieux Helene Canada Rimouski Blier Pierre U Canada Antigonish Kane Daniel A Canada Rimouski Vandermeeren E Croatia Zagreb Saric A Croatia Split Mihanovic I Czech Republic Hradec Králové Waldauf P Czech Republic Pilsen Markova Michaela Czech Republic Prague Elkalaf Moustafa Czech Republic Prague 10 Krajcova Adela Czech Republic Pilsen Kuncova J Denmark Malov Hey-Mogensen M Denmark Copenhagen Dela Flemming Denmark Copenhagen N Mortensen OH Denmark Copenhagen Larsen Steen Denmark Hvidovre Nehlin Jan O Denmark Copenhagen Gonzalez-Franquesa Alba Estonia Tallinn Puurand Marju Estonia Tallinn Truu Laura Estonia Tallinn Kaambre Tuuli Estonia Tallinn Tepp Kersti Estonia Tallinn Vendelin Marko Estonia Tallinn Aid-Vanakova Jekaterina Estonia Tallinn Karro N Estonia Tartu Paju Kalju Finland Jyvaeskylae Lehti Maarit Finland Helsinki Pirinen E France Paris Armand Anne-Sophie France Paris Petit Patrice X France Bordeaux cedex Mourier A France Grenoble Cedex 9 Schlattner Uwe France Montpellier Cedex 1 Chabi Beatrice France Grenoble cedex 9 Dubouchaud Herve France Paris Ventura-Clapier R France Montpellier Cortade F Germany Duesseldorf Jelenik T Germany Bremerhaven Mark Felix Christopher Germany Leipzig Ost Mario Germany Cologne Pesta Dominik Germany Rostock Haider F Germany Nuthetal Klaus S Germany Munich Jastroch M Germany Bochum Platen P Germany Köln Kimoloi Sammy Germany Duesseldorf Roden Michael Germany Düsseldorf Granata Cesare Greece Heraklio Sidiropoulou K Greece Athens Trougakos Ioannis P Greece Heraklion Tavernarakis Nektarios India Haryana Sharma Vipin Ireland Sligo Murphy J Ireland Dublin O'Gorman Donal Ireland Dublin Porter Richard K Israel Rishon Le Zion Hachmo Yafit Israel Zrifin Sova Marina Israel Jerusalem Saada Reisch Ann Italia Udine Salvadego Desy Italy Milan Giovarelli Matteo Italy Bologna Genova Maria Luisa Italy Pisa Gastaldelli Amalia Italy Novara Reano Simone Italy Rome Scatena Roberto Italy Milan De Palma Clara Japan Sapporo Shirakawa R Japan Sapporo Nambu H Japan Sapporo Maekawa S Latvia Riga Liepins Edgars Latvia Riga Kuka Janis Latvia Riga Zvejniece Liga Latvia Riga Inashkina I Luxembourg Strassen Devaux Yvan Malta Msida Vella Joanna Netherlands Maastricht Hoeks Joris Netherlands BT Amsterdam Jaspers Richard T Netherlands Maastricht Grevendonk L Netherlands Wageningen Keijer Jaap Netherlands Maastricht Van Polanen N Netherlands Amsterdam De Goede Paul Niederlande ER Masstricht De Theije C Niederlande ER Masstricht De Wit-Verheggen V Norway Oslo Torp May-Kristin Norway Oslo Nikolic N Norway Tromsoe Jansen Kirsten M Norway Oslo Rustan AC Norway Oslo Eide L Norway Bergen Tronstad Karl Johan Norway Tromsoe Larsen Terje S Norway Tromsoe Schots Pauke C Norway Ullevål Heiestad Christina Norway Oslo Lund Jenny Norway Tromsoe Aasum E Poland Lodz Watala Cezary Poland Lodz Labieniec-Watala Magdalena Poland Warsaw Sek Aleksandra Poland Warsaw Kampa Rafal Pawel Poland Warsaw Dymkowska Dorota Portugal Porto Beleza Jorge Portugal Cantanhede Martins Joao D Portugal Coimbra Martins Marques T Portugal Cantanhede Ferreira LL Portugal Porto Coxito Pedro Portugal Coimbra Palmeira Carlos Portugal Porto Magalhaes Jose Portugal Coimbra Carvalho Eugenia Portugal Coimbra Pereira Susana P Romania Timisoara Lighezan R Romania Timisoara Muntean Danina M Singapore Singapore Hausenloy Derek J Slovakia Bratislava Sumbalova Zuzana Slovakia Bratislava Ukropcova B Slovakia Bratislava Maderova D Slovakia Bratislava Nemec Michal Slovakia Bratislava Ukropec J Slovenia Ljubljana Pirkmajer Sergej Slovenia Ljubljana Dolinar K Slovenia Ljubljana Mars T South Africa Smith James Spain Barcelona Gama Perez Pau Spain Armilla, Granada Escames Germaine Spain A Coruña Blanco FJ Spain Barcelona Garcia-Roves Pablo Miguel Spain Barcelona Guitart M Spain Granada Lopez Garcia Luis Carlos Spain Madrid Cadenas S Spain Madrid Moran M Spain Barcelona Sebastian D Spain Barcelona Zorzano Antonio Spain Barcelona De la Torre Lara J Spain Sevilla Bustos Matilde Spain Barcelona Catalan M Spain Armilla (Granada) Acuna-Castroviejo Dario Spain Barcelona Batlle M Spain Armilla (Granada) Fernandez-Ortiz Marisol Sweden Linköping Fontes-Oliveira CC Sweden Stockholm Cardinale Daniele A Switzerland Lausanne Morato Fornaguera L Switzerland Lausanne Sandi Carmen Switzerland Bern Nuoffer Jean-Marc Switzerland Lausanne Weger M Switzerland Lausanne Zalachoras I Switzerland Lausanne Gebara E The Netherlands Wageningen Van der Ende Miranda The Netherlands BT Amsterdam Wuest Rob CI Turkey Ankara Tuncay Erkan USA Boca Raton Khamoui Andy V USA Little Rock Porter Craig USA St Louis Welch R USA Baton Rouge Axelrod Christopher L USA Gainesville Wohlgemuth Stephanie E USA Gainesville Neyroud D USA College Station Latham C USA Orlando Coen Paul M USA Chicago Dayanidhi Sudarshan USA Baton Rouge Irving Brian A USA Fairbanks O'Brien Kristin USA Torrance Rossiter Harry B USA Baltimore Gonzalez-Freire Marta USA College Station White-Springer Sarah H USA Fort Collins Chicco Adam J USA Colorado Springs Jacobs RA USA Norfolk Lai Nicola USA Gainesville Hepple Russell T USA Seattle Marcinek DJ USA Baltimore Fang Evandro F USA Ann Arbor Beard Daniel A USA Orlando Distefano Giovanna United Kingdom Manchester Giakoumaki I United Kingdom London Szabadkai Gyorgy United Kingdom Loughborough Ebanks Brad United Kingdom Plymouth, Devon McKenna Helen T United Kingdom Birmingham Garten Antje United Kingdom Birmingham Thakker A United Kingdom Leeds Boyle JP United Kingdom Brighton Moore Anthony L United Kingdom Cambridge Shiroma Jonathan G United Kingdom Nottingham Chakrabarti Lisa United Kingdom Cambridge Murray Andrew James United Kingdom Birmingham Ashcroft S United Kingdom Oxford Makrecka-Kuka Marina United Kingdom Birmingham Joanisse S United States Providence Siamwala J
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
Projects in progress
- » MiPMap
