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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping
MitoEAGLE data: muscle
WG2
- MITOEAGLE data repository in muscle and other tissues
WG2 Description
- During the past 10 years, a dramatically increasing number of studies report respirometric data on human muscle tissue (e.g. Christiansen 2015 Am J Physiol). Muscle mitochondrial function is particularly studied in genetically engineered mouse models of human diseases (e.g. Jelenik 2014 Diabetes). However, despite the many published data, lack of consistency often precludes quantitative comparison among data sets with permeabilized or homogenized muscle fibres or isolated mitochondria, normalized to either tissue wet weight, dry weight, protein content, citrate synthase activity or other mitochondrial markers. In the absence of validated conversion factors, these data remain largely unconnected and can only be qualitatively linked.
- The aim of WG2 will be to provide access to complete data sets for post-study statistical analysis and use harmonization tools (WG1) for standardized documentation, to initiate a data repository on muscle tissue from humans and model organisms in health and disease. Data sets shall be obtained from already published and new studies, prompting participating labs to report experimental details beyond those already published as far as possible (using tools such as PubMed Commons). As a result, specific protocols will be summarized for handling muscle tissue. Depending on specific interests, WG2 may decide to extend their focus to other tissue types.
WG2 Participants
| Country | City | Contact |
|---|---|---|
| Australia | Melbourne | Bishop David J |
| Austria | Innsbruck | Gnaiger Erich |
| Austria | Salzburg | Mayr JA |
| Austria | Innsbruck | Doerrier Carolina |
| Austria | Innsbruck | Laner Verena |
| Belgium | Leuven | Bird Matthew |
| Belgium | Liege | Votion Dominique-Marie |
| Brazil | São Paulo | Ferreira Julio Cesar B |
| Brazil | Jaboticabal, SP | Garcia Geovana S |
| Canada | Antigonish | Kane Daniel A |
| Canada | Rimouski | Vandermeeren E |
| Canada | Rimouski | Blier Pierre U |
| Canada | Vancouver | Boushel Robert C |
| Canada | Edmonton (Alberta) | Lemieux Helene |
| Croatia | Zagreb | Saric A |
| Croatia | Split | Mihanovic I |
| Czech Republic | Prague 10 | Krajcova Adela |
| Czech Republic | Prague | Elkalaf Moustafa |
| Czech Republic | Pilsen | Kuncova J |
| Czech Republic | Hradec Králové | Waldauf P |
| Czech Republic | Pilsen | Markova Michaela |
| Denmark | Copenhagen | Dela Flemming |
| Denmark | Copenhagen N | Mortensen OH |
| Denmark | Copenhagen | Larsen Steen |
| Denmark | Hvidovre | Nehlin Jan O |
| Denmark | Copenhagen | Gonzalez-Franquesa Alba |
| Denmark | Malov | Hey-Mogensen M |
| Estonia | Tallinn | Truu Laura |
| Estonia | Tallinn | Aid-Vanakova Jekaterina |
| Estonia | Tallinn | Kaambre Tuuli |
| Estonia | Tallinn | Karro N |
| Estonia | Tartu | Paju Kalju |
| Estonia | Tallinn | Tepp Kersti |
| Estonia | Tallinn | Vendelin Marko |
| Estonia | Tallinn | Puurand Marju |
| Finland | Helsinki | Pirinen E |
| Finland | Jyvaeskylae | Lehti Maarit |
| France | Grenoble Cedex 9 | Schlattner Uwe |
| France | Montpellier | Cortade F |
| France | Montpellier Cedex 1 | Chabi Beatrice |
| France | Paris | Armand Anne-Sophie |
| France | Paris | Petit Patrice X |
| France | Paris | Ventura-Clapier R |
| France | Grenoble cedex 9 | Dubouchaud Herve |
| France | Bordeaux cedex | Mourier A |
| Germany | Leipzig | Ost Mario |
| Germany | Cologne | Pesta Dominik |
| Germany | Rostock | Haider F |
| Germany | Köln | Kimoloi Sammy |
| Germany | Nuthetal | Klaus S |
| Germany | Munich | Jastroch M |
| Germany | Bochum | Platen P |
| Germany | Bremerhaven | Mark Felix Christopher |
| Germany | Duesseldorf | Roden Michael |
| Germany | Düsseldorf | Granata Cesare |
| Germany | Duesseldorf | Jelenik T |
| Greece | Heraklion | Tavernarakis Nektarios |
| Greece | Heraklio | Sidiropoulou K |
| Greece | Athens | Trougakos Ioannis P |
| India | Haryana | Sharma Vipin |
| Ireland | Dublin | O'Gorman Donal |
| Ireland | Dublin | Porter Richard K |
| Ireland | Sligo | Murphy J |
| Israel | Rishon Le Zion | Hachmo Yafit |
| Israel | Zrifin | Sova Marina |
| Israel | Jerusalem | Saada Reisch Ann |
| Italia | Udine | Salvadego Desy |
| Italy | Bologna | Genova Maria Luisa |
| Italy | Rome | Scatena Roberto |
| Italy | Milan | De Palma Clara |
| Italy | Pisa | Gastaldelli Amalia |
| Italy | Milan | Giovarelli Matteo |
| Italy | Novara | Reano Simone |
| Japan | Sapporo | Shirakawa R |
| Japan | Sapporo | Nambu H |
| Japan | Sapporo | Maekawa S |
| Latvia | Riga | Inashkina I |
| Latvia | Riga | Kuka Janis |
| Latvia | Riga | Liepins Edgars |
| Latvia | Riga | Zvejniece Liga |
| Luxembourg | Strassen | Devaux Yvan |
| Malta | Msida | Vella Joanna |
| Netherlands | Maastricht | Grevendonk L |
| Netherlands | Wageningen | Keijer Jaap |
| Netherlands | Maastricht | Van Polanen N |
| Netherlands | Amsterdam | De Goede Paul |
| Netherlands | BT Amsterdam | Jaspers Richard T |
| Netherlands | Maastricht | Hoeks Joris |
| Niederlande | ER Masstricht | De Theije C |
| Niederlande | ER Masstricht | De Wit-Verheggen V |
| Norway | Tromsoe | Schots Pauke C |
| Norway | Oslo | Rustan AC |
| Norway | Ullevål | Heiestad Christina |
| Norway | Oslo | Eide L |
| Norway | Bergen | Tronstad Karl Johan |
| Norway | Oslo | Lund Jenny |
| Norway | Tromsoe | Larsen Terje S |
| Norway | Oslo | Torp May-Kristin |
| Norway | Tromsoe | Jansen Kirsten M |
| Norway | Tromsoe | Aasum E |
| Norway | Oslo | Nikolic N |
| Poland | Lodz | Labieniec-Watala Magdalena |
| Poland | Warsaw | Dymkowska Dorota |
| Poland | Warsaw | Sek Aleksandra |
| Poland | Lodz | Watala Cezary |
| Poland | Warsaw | Kampa Rafal Pawel |
| Portugal | Porto | Magalhaes Jose |
| Portugal | Coimbra | Pereira Susana P |
| Portugal | Coimbra | Palmeira Carlos |
| Portugal | Coimbra | Carvalho Eugenia |
| Portugal | Porto | Beleza Jorge |
| Portugal | Cantanhede | Martins Joao D |
| Portugal | Cantanhede | Ferreira LL |
| Portugal | Coimbra | Martins Marques T |
| Portugal | Porto | Coxito Pedro |
| Romania | Timisoara | Lighezan R |
| Romania | Timisoara | Muntean Danina M |
| Singapore | Singapore | Hausenloy Derek J |
| Slovakia | Bratislava | Ukropcova B |
| Slovakia | Bratislava | Maderova D |
| Slovakia | Bratislava | Nemec Michal |
| Slovakia | Bratislava | Ukropec J |
| Slovakia | Bratislava | Sumbalova Zuzana |
| Slovenia | Ljubljana | Pirkmajer Sergej |
| Slovenia | Ljubljana | Dolinar K |
| Slovenia | Ljubljana | Mars T |
| South Africa | Smith James | |
| Spain | Barcelona | De la Torre Lara J |
| Spain | Sevilla | Bustos Matilde |
| Spain | Granada | Lopez Garcia Luis Carlos |
| Spain | Madrid | Cadenas S |
| Spain | Madrid | Moran M |
| Spain | Barcelona | Batlle M |
| Spain | Armilla (Granada) | Fernandez-Ortiz Marisol |
| Spain | Barcelona | Sebastian D |
| Spain | Barcelona | Zorzano Antonio |
| Spain | Barcelona | Garcia-Roves Pablo Miguel |
| Spain | Barcelona | Catalan M |
| Spain | Armilla (Granada) | Acuna-Castroviejo Dario |
| Spain | Barcelona | Gama Perez Pau |
| Spain | Armilla, Granada | Escames Germaine |
| Spain | A Coruña | Blanco FJ |
| Spain | Barcelona | Guitart M |
| Sweden | Stockholm | Cardinale Daniele A |
| Sweden | Linköping | Fontes-Oliveira CC |
| Switzerland | Lausanne | Zalachoras I |
| Switzerland | Lausanne | Gebara E |
| Switzerland | Bern | Nuoffer Jean-Marc |
| Switzerland | Lausanne | Morato Fornaguera L |
| Switzerland | Lausanne | Sandi Carmen |
| Switzerland | Lausanne | Weger M |
| The Netherlands | BT Amsterdam | Wuest Rob CI |
| The Netherlands | Wageningen | Van der Ende Miranda |
| Turkey | Ankara | Tuncay Erkan |
| USA | Orlando | Coen Paul M |
| USA | Baton Rouge | Irving Brian A |
| USA | Torrance | Rossiter Harry B |
| USA | Fort Collins | Chicco Adam J |
| USA | Boca Raton | Khamoui Andy V |
| USA | Colorado Springs | Jacobs RA |
| USA | Norfolk | Lai Nicola |
| USA | Baton Rouge | Axelrod Christopher L |
| USA | Gainesville | Hepple Russell T |
| USA | Seattle | Marcinek DJ |
| USA | Baltimore | Fang Evandro F |
| USA | Ann Arbor | Beard Daniel A |
| USA | Orlando | Distefano Giovanna |
| USA | Chicago | Dayanidhi Sudarshan |
| USA | Fairbanks | O'Brien Kristin |
| USA | Baltimore | Gonzalez-Freire Marta |
| USA | Little Rock | Porter Craig |
| USA | St Louis | Welch R |
| USA | College Station | White-Springer Sarah H |
| USA | Gainesville | Wohlgemuth Stephanie E |
| USA | Gainesville | Neyroud D |
| USA | College Station | Latham C |
| United Kingdom | Cambridge | Shiroma Jonathan G |
| United Kingdom | Brighton | Moore Anthony L |
| United Kingdom | Cambridge | Murray Andrew James |
| United Kingdom | London | Szabadkai Gyorgy |
| United Kingdom | Birmingham | Thakker A |
| United Kingdom | Leeds | Boyle JP |
| United Kingdom | Nottingham | Chakrabarti Lisa |
| United Kingdom | Birmingham | Ashcroft S |
| United Kingdom | Oxford | Makrecka-Kuka Marina |
| United Kingdom | Manchester | Giakoumaki I |
| United Kingdom | Birmingham | Joanisse S |
| United Kingdom | Loughborough | Ebanks Brad |
| United Kingdom | Plymouth, Devon | McKenna Helen T |
| United Kingdom | Birmingham | Garten Antje |
| United States | Providence | Siamwala J |
WG2 Management
Tasks
- Call for participating labs to deliver relevant experimental data on already published studies and to report them in a standardized format.
- Collection and indexing of the data sets as required for statistical analysis.
- Discussion of procedures, protocols and general guidelines.
- Draft a comprehensive review on mt-function in muscle tissue (registration at PROSPERO, link with EQUATOR).
- Opening of the database to the research public for data search and moderated entry of new data sets.
Milestones
- Call for data report delivered.
- Data sets entered in standardized format.
- Summary, interpretation and discussion of data for review.
Deliverables
- A MITOEAGLE database on muscle tissue from humans and model organisms.
- A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue.
- Draft of review manuscript.
WG2 Feedback
- Skeletal muscle is the main tissue we are studying in the lab. - Beatrice Chabi (2016).
- For the kind of work group, our expertise is certainly most on muscle tissue (skeletal and heart), although we also worked on all kinds of permeabilized cells (primary cells and cell lines). For all these, we have extended data sets, mainly rat, but also human, from diverse experimental setups (nutritional regimen, exercise, drugs ...). - Uwe Schlattner (2016).
- I would fit rather in WG1, as myself I am not involved in human muscle fat or blood. However, in our team we made a study involving human liver samples. - Frédéric Bouillaud (2016).
- In my working group we are mainly interested in muscle, especially focusing on aging and sarcopenia (using animal models). I would be happy if new cooperations could be formed through the COST Action. I could imagine working on a joint review article. Next to examining muscle from mouse models, we are studying biopsies from human heart muscle and liver, but there is no published data on these studies yet. - Susanne Klaus (2016). Translated by Sandra Fleischmann
- I am very interested in being part of the management committee either as a MC member for managment tasks or in working group 4 MITOEAGLE data repository for blood cells and cultured cells. I have experience in analyzing mitochondrial function in different human tissues as cultured cells and blood cells (also subsets of specific blood populations, see list of publications), muscle and isolated mitochondria. This together with my experience in organizing summer schools and conferences could be helpful as MC member taking care of management tasks. However, if you think my expertise is more helpful in working group 4, I am looking forward to support this working group. - Kathrin Renner-Sattler (2016).
- I am working in the field of mitochondrial biochemistry since many years. In detail my coworkers and I are carrying out studies on the regulation of ATP synthase and respiratory complexes in swine heart mitochondria as biological model of mammalian mitochondria. Some comparative aspects of mitochondrial bioenergetics and ATP synthase responses are also investigated in bivalve mollusk mitochondria. - Alessandra Pagliarani (2016).
Projects in progress
- » MiPMap
