PMS-pathway control state: Difference between revisions
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'''MitoPathway control:''' CI&II | '''MitoPathway control:''' CI&II | ||
[[Pyruvate]] (P) is oxidatively decarboxylated to acetyl-CoA and CO<sub>2</sub>, yielding [[NADH]] catalyzed by pyruvate dehydrogenase. [[Malate]] (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009). | |||
|info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 5.5]] | |info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 5.5]] | ||
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{{MitoPedia concepts | {{MitoPedia concepts | ||
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Revision as of 16:18, 22 January 2019
Description
PMS: Pyruvate & Malate & Succinate.
MitoPathway control: CI&II
Pyruvate (P) is oxidatively decarboxylated to acetyl-CoA and CO2, yielding NADH catalyzed by pyruvate dehydrogenase. Malate (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009).
Abbreviation: PMS
Reference: Gnaiger 2014 MitoPathways - Chapter 5.5
MitoPedia concepts:
SUIT state
PMSL
PMS pathway in the LEAK state can be evaluated in the following SUIT protocols:
PMSP
PMS pathway in the OXPHOS state can be evaluated in the following SUIT protocols:
PMSE
PMS pathway in the ET state can be evaluated in the following SUIT protocols:
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- DL-Protocol for permeabilized fibers (pfi): SUIT-004 O2 pfi D010
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