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...L, Pan JQ, Shu G, Jiang QY, Yin YL, Zhang L (2019) LSD1 mediates microbial metabolite butyrate-induced thermogenesis in brown and white adipose tissue. Metabolis ...ylase and important regulator of thermogenesis, in mediating gut microbial metabolite butyrate regulation of thermogenesis.

...glutamate&malate), but of succinate (S) simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant stimulation of S-linke

...common metabolite that is diminished by mitochondrial ETC inhibitors. PCr depletion decreased ATP levels and NLRP3 inflammasome activation. Thus, the mitochond

...rgent electron-input into the [[Q-junction]], to compensate for metabolite depletion into the incubation medium. NS in combination exerts an [[additive effect o |mitopedia topic=Substrate and metabolite, EAGLE

...rgent electron-input into the [[Q-junction]], to compensate for metabolite depletion into the incubation medium. FS in combination exerts an [[additive effect o

...]) is largely substrate-limited in N-linked respiration, due to metabolite depletion into the incubation medium. The residual involvement of S-linked respiratio

.../sub>O₂ typically present in cells would favor emission of this metabolite but the scavenging systems would prevent its accumulation.

...computational model. While molecular competition did not affect the plasma metabolite profiles during MCAD deficiency, it was a key factor in explaining the char ::* “The resulting flux decline was mediated by a self-amplifying depletion of CoASH.”

...ation of eukaryotic initiation factor 2α are also reversed by Ile. Genetic depletion studies showed that Ile responses are independent of the amino acid transpo

...re it inhibits complex I of the electron transport chain, resulting in ATP depletion and neuronal impairment/death. So far, MPP⁺ is recognized as a v

...oxidative stress, neuronal dysfunction and death. Notably, pharmacological depletion of microglia or treatment with itaconate resulted in effective neuroprotect

...be extended over 1 to 2 hours), highly diluted sample to avoid fast oxygen depletion in the closed chamber, and the possibility for re-oxygenations to extend me |mitopedia topic=Inhibitor, Substrate and metabolite, Uncoupler

...econstituting the operation of the tricarboxylic acid cycle and preventing depletion of key metabolites from the mitochondrial matrix. In human skeletal muscle

.../sub>O₂ typically present in cells would favor emission of this metabolite but the scavenging systems would prevent its accumulation.

...which can both hydrolyze acetylpyruvate and decarboxylate oxaloacetate, a metabolite of the tricarboxylic acid (TCA) cycle. FAHD1 is the first described eukaryo ...d HUVEC had a decreased oxygen consumption rate (Figure 1 E). In addition, depletion of FAHD1 in the breast cancer cell line MCF-7 revealed an inhibition of cel

...rgent electron-input into the [[Q-junction]], to compensate for metabolite depletion into the incubation medium. FNS in combination exerts an [[additive effect

...that tamoxifen enhances the ceramide effect by blocking its metabolism. As depletion of ATP and targeting the "Warburg effect" represent dynamic metabolic insul

...CM. The metabolite profiles of ELVD and TCM were characterised by profound depletion of tricarboxylic acid cycle intermediates. Redox balance was shifted toward

...ion of TCA cycle function in mt-preparations, to compensate for metabolite depletion into the incubation medium. NS in combination exerts an additive effect on

...apacities. Multiple substrates are supplied to counterbalance intermediary metabolite loss from the mitochondria into the dilute incubation medium. Physiological ...ria, specific inhibitors applied to block selected mt-pathways, metabolite depletion from the mt-matrix, and activities of mt-matrix dehydrogenases. Electron ga

...nal electrophoreses, nano-LC-MS/MS, immunogold EM, and stimulated emission depletion microscopy, we show that FAO enzymes physically interact with ETC supercomp ...its enoyl–CoA product with reduction of ETF. The protein complex promotes metabolite channeling for all these reactions. For steps 4 and 5, reduced ETF is relea

...release mechanism - the possibility of ATP requirements or other cellular depletion caused by prodrug metabolism. |mitopedia topic=Inhibitor, Substrate and metabolite

...hondria, permeabilized cells, permeabilized tissues, tissue homogenate) by depletion of endogenous substrates and addition to the mitochondrial respiration medi ...ndogenous. Long-term incubation under such conditions leads to progressive depletion of endogenous substrates.

...hosphorylation. III. The steady state. J Biol Chem 217:409-27. - Substrate depletion in isolated mitochondria is achieved in State 2: ADP is added to induce a t ...ddition of exogenous substrates. In such a study, the conventional initial depletion of endogenous substrates would be most important. (b) Maximal respiration r

...hosphorylation. III. The steady state. J Biol Chem 217:409-27. - Substrate depletion in isolated mitochondria is achieved in State 2: ADP is added to induce a t ...round are considered to be present at low concentrations due to metabolite depletion, whereas products with blue background are considered to accumulate in the

...rations. These protocols ignored the importance of cataplerotic metabolite depletion in the tricarboxylic acid (TCA) cycle. ...eady state. - [[Chance 1955 J Biol Chem-III |»Bioblast link«]] - Substrate depletion in isolated mitochondria is achieved in State 2: ADP is added to induce a t

...f externally added uncouplers (i) in the absence of adenylates, (ii) after depletion of ADP, or (iii) after inhibition of ATP synthase or adenine nucleotide tra .../7b/Cronin_2018_Nature_O2k-brief.pdf|O2k-brief]] '''Cronin''' (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature - '''L