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A list of all pages that have property "Has abstract" with value "Ischemic stroke is one of the leading causes of disability and mortality worldwide, but therapeutic approach are limited. Ischemia causes inhibition of mitochondrial respiration, mitochondrial permeability transition pore (MPTP) opening and subsequent cell death processes. The risk for ischemic stroke is increasing with aging, but there is very little information about aging-related changes in mitochondrial functions and proteomics. In this study, we investigated ischemic lesions to 7 days, 2-3, 7-10 and 24-26 months-old rats brain mitochondria respiration and MPTP sensitivity to Ca2+ with particular focus on mitochondrial Complex I. Results have shown that hypoxia inhibited cortical mitochondrial respiration rate of animals from all age groups and reduced mitochondrial calcium retention capacity (CRC) in 2-3, 7-10 and 24-26 months animals groups. Hypoxia induced inhibition of cerebellar mitochondrial respiration in 7 days, 2-3 and 24 month-old groups, but in the 7-10 month-old group there were no statistically significant effect compared to control. CRC after hypoxia were reduced in 10 and 24-26 months - old rats cerebellum. Further injury investigation revealed that hypoxia inhibits the activity of Complex I in 2-3, 7-10 and 24-26 month-animals. Mitochondrial protein expression study showed an age-related decrease of Complex I protein NDUFS2 levels and subsequent increase in mitochondrial respiration in aged animals. Altogether, we demonstrated that hypoxia induces MPTP opening and inhibits mitochondrial Complex I activity in adult and aged animals groups.". Since there have been only a few results, also nearby values are displayed.

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Arandarcikaite 2022 Abstract Bioblast + (Ischemic stroke is one of the leading caus … Ischemic stroke is one of the leading causes of disability and mortality worldwide, but therapeutic approach are limited. Ischemia causes inhibition of mitochondrial respiration, mitochondrial permeability transition pore (MPTP) opening and subsequent cell death processes. The risk for ischemic stroke is increasing with aging, but there is very little information about aging-related changes in mitochondrial functions and proteomics.In this study, we investigated ischemic lesions to 7 days, 2-3, 7-10 and 24-26 months-old rats brain mitochondria respiration and MPTP sensitivity to Ca2+ with particular focus on mitochondrial Complex I. Results have shown that hypoxia inhibited cortical mitochondrial respiration rate of animals from all age groups and reduced mitochondrial calcium retention capacity (CRC) in 2-3, 7-10 and 24-26 months animals groups. Hypoxia induced inhibition of cerebellar mitochondrial respiration in 7 days, 2-3 and 24 month-old groups, but in the 7-10 month-old group there were no statistically significant effect compared to control. CRC after hypoxia were reduced in 10 and 24-26 months - old rats cerebellum.Further injury investigation revealed that hypoxia inhibits the activity of Complex I in 2-3, 7-10 and 24-26 month-animals. Mitochondrial protein expression study showed an age-related decrease of Complex I protein NDUFS2 levels and subsequent increase in mitochondrial respiration in aged animals. Altogether, we demonstrated that hypoxia induces MPTP opening and inhibits mitochondrial Complex I activity in adult and aged animals groups.l Complex I activity in adult and aged animals groups.)

Arandarcikaite 2022 Abstract Bioblast +