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- Barbieri 2016 Abstract Mito Xmas Meeting Innsbruck + (The role of the outer mitochondrial membra … The role of the outer mitochondrial membrane protein Fission 1 (FIS1) as a mitochondrial receptor for the pro-fission dynamin related protein 1 (DRP1) has been recently challenged and Fis1 has been conversely implied in mitophagy, but the molecular mechanisms governing FIS1 involvement in mitochondrial morphology and autophagy are unclear. Here we show that both human and mouse FIS1 genes give rise to splicing variants with opposite effect on mitochondrial morphology. FIS1 variant 1 or 3 trigger fragmentation whereas variant 2 induces mitochondrial elongation. Upon starvation, FIS1 variant 2 expression is up-regulated in a protein kinase A-dependent manner and its specific knockdown inhibits autophagy associated mitochondrial elongation. Thus, FIS1 is alternatively spliced to modulate mitochondrial morphology during autophagy.mitochondrial morphology during autophagy.)
