Search by property

This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

Search by property

Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0AIn-20recent-20years,-20research-20of-20mitochondrial-20(mt)-20function-20received-20an-20increasing-20interest-20in-20the-20context-20of-20many-20pathophysiological-20conditions.-20Identification-20of-20metabolic-20reprogramming-20and-20specific-20defects-20in-20mt-2Dpathways-20is-20critical-20for-20diagnosis-20and-20selection-20of-20targeted-20treatments.-20Fatty-20acid-20oxidation-20(FAO,-20F-2Dpathway)-20plays-20an-20essential-20role-20in-20many-20pathologies-20(e.g.-20insulin-20resistance,-20heart-20failure,-20ischemia-2Dreperfusion,-20cancer)-20and-20must-20therefore-20be-20studied-20carefully.-20Here-20we-20show-20that-20respirometric-20measurements-20can-20significantly-20overestimate-20F-2Dpathway-20capacities-20due-20to-20activation-20of-20anaplerotic-20pathways-20(e.g.-20mt-2Dmalic-20enzyme)-20-5B1,2-5D.-20F-2Dpathway-20respiration-20requires-20the-20combined-20use-20of-20fatty-20acid(s)-20(FA)-20and-20malate-20to-20avoid-20acetyl-2DCoA-20accumulation-20which-20inhibits-20mt-2Drespiration.-20In-20the-20presence-20of-20enzymes-20supporting-20malate-2D-20and-20pyruvate-2Dlinked-20anaplerotic-20pathways-20the-20widely-20used-20malate-20concentration-20of-202-20mM-20supports-20NADH-2Dlinked-20(N-2D)-20respiration-20in-20addition-20to-20the-20F-2Dpathway,-20resulting-20in-20overestimation-20of-20F-2DOXPHOS-20capacity.-20We-20developed-20the-20substrate-2Duncoupler-2Dinhibitor-20titration-20(SUIT)-20protocol-20RP2-20for-20reliable-20FAO-20evaluation-20by-20high-2Dresolution-20respirometry-20(HRR).-20By-20comparison,-20we-20quantified-20the-20degree-20of-20FAO-20overestimation-20in-20several-20mouse-20and-20human-20mt-2Dpreparations.-20In-20conclusion,-20HRR-20allows-20the-20accurate-20study-20of-20mt-2Dpathways,-20including-20F-2Dpathway-20capacity,-20which-20is-20required-20for-20comprehensive-20OXPHOS-20analysis-20in-20diagnostic-20studies-20of-20mt-2Dfunction." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)

Property: Value:

List of results

No results.