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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0AThe-20fundamental-20property-20of-20somatic-20cells-20in-20higher-20mammals-20is-20their-20limited-20spanision-20capacity-20ending-20in-20cellular-20senescence.-20Two-20main-20mechanisms-20contribute-20to-20cellular-20senescence,-20telomere-20shortening-20and-20damaging-20effects-20of-20free-20radicals,-20mostly-20generated-20by-20mitochondria.-20It-20is-20well-20established-20that-20these-20two-20mechanisms-20are-20in-20mutual-20interactions-20but-20many-20aspects-20of-20these-20interactions-20still-20remain-20to-20be-20elucidated.-20This-20was-20clearly-20demonstrated-20in-20the-20experiments-20in-20which-20cell-20growth-20and-20senescence,-20as-20well-20as-20telomere-20shortening-20are-20directly-20dependent-20on-20oxygen-20partial-20pressure-20-5B1-5D.-20However,-20expression-20of-20telomerase-20(TERT),-20an-20enzyme-20that-20extends-20telomeres,-20recovers-20cells-20from-20senescence-20and-20restores-20mitochondrial-20function.-20This-20includes-20TERT-20translocation-20from-20the-20nucleus-20and-20localisation-20to-20mitochondria.-20It-20appears-20that-20TERT-20protects-20mitochondria-20from-20hyperoxia-2Dinduced-20damage-20in-20a-20way-20that-20both-20mitochondrial-20DNA-20damage-20and-20superoxide-20production-20decrease-20and-20the-20mitochondrial-20membrane-20potential-20elevates.-20Also-20these-20cells-20have-20enhanced-20resistance-20to-20apoptosis-20-5B2-5D.-20This-20lecture-20will-20present-20new-20findings-20in-20research-20on-20cell-20senescence,-20aging-20and-20rejuvenation-20and-20the-20role-20of-20mitochondria-20in-20these-20processes." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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