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Bullon 2015 Pharmacol Res

From Bioblast
Publications in the MiPMap
Bullón P, Román-Malo L, Marín-Aguilar F, Alvarez-Suarez JM, Giampieri F, Battino M, Cordero MD (2015) Lipophilic antioxidants prevent lipopolysaccharide-induced mitochondrial dysfunction through mitochondrial biogenesis improvement. Pharmacol Res 91:1-8.

» PMID: 25447593

Bullon P, Roman-Malo L, Marin-Aguilar F, Alvarez-Suarez JM, Giampieri F, Battino M, Cordero MD (2015) Pharmacol Res

Abstract: Oxidative stress is implicated in several infectious diseases. In this regard, lipopolysaccharide (LPS), an endotoxic component, induces mitochondrial dysfunction and oxidative stress in several pathological events such as periodontal disease or sepsis. In our experiments, LPS-treated fibroblasts provoked increased oxidative stress, mitochondrial dysfunction, reduced oxygen consumption and mitochondrial biogenesis. After comparing coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), we observed a more significant protection of CoQ10 than of NAC, which was comparable with other lipophilic and hydrophilic antioxidants such as vitamin E or BHA respectively. CoQ10 improved mitochondrial biogenesis by activating PGC-1α and TFAM. This lipophilic antioxidant protection was observed in mice after LPS injection. These results show that mitochondria-targeted lipophilic antioxidants could be a possible specific therapeutic strategy in pharmacology in the treatment of infectious diseases and their complications.

Copyright © 2014 Elsevier Ltd. All rights reserved.


Labels: MiParea: mt-Biogenesis;mt-density 

Stress:Oxidative stress;RONS  Organism: Mouse  Tissue;cell: Fibroblast