Flavonoids

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Flavonoids

Description

Flavonoids are a group of bioactive polyphenols with potential antioxidant and anti-inflammatory effects, abundant in fruits and vegetables, and in some medicinal herbs. Flavonoids are synthesized in plants from phenylalanine. Dietary intake of flavonoids as nutraceuticals is discussed for targeting T2D and other degenerative diseases.

Flavonoids and mitObesity

Work in progress by Gnaiger E 2020-02-12 linked to a preprint in preparation on BME and mitObesity.

References: Flavonoids

 YearReferenceOrganismTissue;cell
Doucet 2018 Mol Pharmacol2018Doucet MS, Jougleux JL, Poirier SJ, Cormier M, Leger JL, Surette ME, Pichaud N, Touaibia M, Boudreau LH (2018) Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets. Mol Pharmacol 95:139-50.HumanPlatelet
Blood cells
Ruiz 2017 LWT- Food Science Technology2017Ruiz VE, Cerioni L, Zampini IC, Cuello S, Isla MI, Hilal M, Rapisarda VA (2017) UV-B radiation on lemons enhances antifungal activity of flavedo extracts against Penicillium digitatum. LWT- Food Science Technology 85:96-103.Fungi
Skemiene 2015 FEBS J2015Skemiene K, Liobikas J, Borutaite V (2015) Anthocyanins as substrates for mitochondrial complex I - protective effect against heart ischemic injury. FEBS J 282:963-71.RatHeart
Suarez 2015 PhD Thesis2015Suárez Cunza S (2015) Actividad captadora de Radicales libres y Effecto antioxidante de Metabolitos secundarios del extracto acuoso des "Allium sativum" var. Huaralino (Ajo) en Modelos in vitro. PhD Thesis 1-39.RatLiver
Messerli 2012 New England J Med2012Messerli FH (2012) Chocolate consumption, cognitive function, and Nobel laureates. New England J Med 367:1562-4.Human
 YearReferenceOrganismTissue;cell
Sek 2019 ASMRM20192019Sęk A, Kampa RP, Kulawiak B, Bauer T, Szewczyk A, Bednarczyk P (2019) Localization of the BKCa channel in the inner mitochondrial membrane of human bronchial epithelial cell line. ASMRM2019.HumanEndothelial;epithelial;mesothelial cell
Kampa 2019 ASMRM20192019Kampa RP, Sęk A, Kicińska A, Jarmuszkiewicz W, Szewczyk A, Bednarczyk P (2019) Natural compounds as a modulators of mitochondrial large conductance Ca2+-regulated potassium channel (mitoBKCa) activity. ASMRM2019.Endothelial;epithelial;mesothelial cell
Kampa 2018 MiPschool Tromso C22018
Rafal Kampa
Cardioprotective flavoniods as a natural modulators of mitoBKCa channel.
HumanEndothelial;epithelial;mesothelial cell
Kolonics 2017 MiP20172017
Attila Kolonics
Different molecular composition of Lysimachia species result in distinct metabolism.
Mouse
Plants
Heart
Liver
El-Bacha 2014 Abstract MiP20142014Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells.HumanLiver
  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946223/
  2. https://www.researchgate.net/publication/338436124_Flavonoids_and_type_2_diabetes_Evidence_of_efficacy_in_clinical_and_animal_studies_and_delivery_strategies_to_enhance_their_therapeutic_efficacy

MitoPedia: mitObesity drugs

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TermAbbreviationDescription
CurcuminCurcumin has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant and anti-infective effects. The protective effects of curcumin on rat heart mitochondrial injuries induced by in vitro anoxia–reoxygenation were evaluated by Xu et al 2013. It was found that curcumin added before anoxia or immediately prior to reoxygenation exhibited remarkable protective effects against anoxia–reoxygenation induced oxidative damage to mitochondria.
ElamipretideBendaviaBendavia (Elamipretide) was developed as a mitochondria-targeted drug against degenerative diseases, including cardiac ischemia-reperfusion injury. Clinical trials showed variable results. It is a cationic tetrapeptide which readily passes cell membranes, associates with cardiolipin in the mitochondrial inner membrane. Supercomplex-associated CIV activity significantly improved in response to elamipretide treatment in the failing human heart.
FlavonoidsFlavonoids are a group of bioactive polyphenols with potential antioxidant and anti-inflammatory effects, abundant in fruits and vegetables, and in some medicinal herbs. Flavonoids are synthesized in plants from phenylalanine. Dietary intake of flavonoids as nutraceuticals is discussed for targeting T2D and other degenerative diseases.
MelatoninaMTMelatonin (N-acetyl-5-methoxytryptamine, aMT) is a highly conserved molecule present in unicellular to vertebrate organisms. Melatonin is synthesized from tryptophan in the pinealocytes by the pineal gland and also is produced in other organs, tissues and fluids (extrapineal melatonin). Melatonin has lipophilic and hydrophilic nature which allows it to cross biological membranes. Therefore, melatonin is present in all subcellular compartments predominantly in the nucleus and mitochondria. Melatonin has pleiotropic functions with powerful antioxidant, anti-inflammatory and oncostatic effects with a wide spectrum of action particularly at the level of mitochondria. » MiPNet article
MetforminMetformin is mainly known as an important antidiabetic drug which is effective, however, in a wide spectrum of degenerative diseases. It is an inhibitor of Complex I.
RapamycinRapamycin is an inhibitor of the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). Rapamycin induces autophagy and dyscouples mitochondrial respiration. Rapamycin delays senescence in human cells, and extends lifespan in mice without detrimental effects on mitochondrial fitness in skeletal muscle.
ResveratrolResveratrol is a natural bioactive phenol prouced by several plants with antioxidant and anti-inflammatory effects. Dietary intake as nutraceutical is discussed for targeting mitochondria with a wide spectrum of action in degenerative diseases.
SpermidineSpermidine is a polycationic bioactive polyamine mainly found in wheat germ, soybean and various vegetables, involved in the regulation of mitophagy, cell growth and cell death. Like other caloric restriction mimetics, spermidine is effective in cardioprotection, neuroprotection and anticancer immunosuppression by preserving mitochondrial function and control of autophagy.
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