O2k-FluoRespirometer

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O2k-Open Support

O2k-FluoRespirometer



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MitoPedia O2k and high-resolution respirometry: O2k-Open Support 



Description

O2k-FluoRespirometer

The Oroboros O2k-FluoRespirometer - the experimental system complete for high-resolution respirometry (HRR), including fluorometry, the TIP2k and the O2k-sV-Module allowing simultaneous monitoring of oxygen consumption together with either ROS production (AmR), mt-membrane potential (TMRM, Safranin and Rhodamine 123), Ca2+ (CaG) or ATP production (MgG).

The O2k-FluoRespirometer supports all add-on O2k-Modules: O2k-TPP+ ISE-Module, O2k-pH ISE-Module, O2k-NO Amp-Module, enabling measurement of mt-membrane potential with ion sensitive electrodes (ISE for TPP+ or TPMP+) or pH.


Reference: Product details and purchase information



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O2k-Series H and I: Features

O2k-FluoRespirometer


O2k-Series I is the latest version of the Oroboros O2k for high-resolution respirometry and O2k-MultiSensor applications. The O2k-Series I sets a new standard in merging high-end technology and corporate social responsibility.

  • Smart Fluorescence-Sensors of the O2k-Fluo Smart-Module are pre-calibrated and the calibration value is stored in the sensor just like its individual ID. Upon connecting the sensor, the O2k-FluoRespirometer identifies it and adjusts itself to the pre-set calibration data. This feature is only available if the sensors are used with O2k-Series H or newer.
  • DatLab 7 is the current version of software, with integrated DatLab Protocols, improved traceability, quality control, and many more features.
  • USB-C 2.0 (2 external ports - O2k-Series I only) for ISS Series E power supply and USB A 2.0 (2 external ports,O2k-Series I; 4 for O2k-Series H) for additional USB devices.
  • Increased energy efficiency based on the updated O2k-electronics design: power consumption is 24 W at 37 °C (80 % reduction compared to Series D). Running costs are substantially lower as a result of our general concept for sustainable technology. The maximal power input is 120 W.


Additional resources

» O2k-FluoRespirometer manual
» O2k-Demo experiments
» MitoPedia: Fluorometry
» Sole source information
» Oroboros O2k
O2k-Publications in the MiPMap

»O2k-Publications: Topics

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Default sorting: chronological. Empty fields appear first in ascending order. 
 Was published in yearHas titleOrganismTissue;cell
MiPNet18.10 O2k-Specifications2024-03-26
Oroboros
O2k-specifications for respirometry and comprehensive OXPHOS analysis.
HumanFibroblast
Li 2024 Sci Rep2024Li J, Zhang S, Li C, Zhang X, Shan Y, Zhang Z, Bo H, Zhang Y (2024) Endurance exercise-induced histone methylation modification involved in skeletal muscle fiber type transition and mitochondrial biogenesis. Sci Rep 14:21154. https://doi.org/10.1038/s41598-024-72088-6RatSkeletal muscle
Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis2024Balmaceda V, Komlodi T, Szibor M, Gnaiger E, Moore AL, Fernandez-Vizarra E, Viscomi C (2024) The striking differences in the bioenergetics of brain and liver mitochondria are enhanced in mitochondrial disease. Biochim Biophys Acta Mol Basis Dis 1870:167033. https://doi.org/10.1016/j.bbadis.2024.167033MouseNervous system
Liver
Ravasz 2024 Sci Rep2024Ravasz D, Bui D, Nazarian S, Pallag G, Karnok N, Roberts J, Marzullo BP, Tennant DA, Greenwood B, Kitayev A, Hill C, Komlódi T, Doerrier C, Cunatova K, Fernandez-Vizarra E, Gnaiger E, Kiebish Michael A, Raska A, Kolev K, Czumbel B, Narain NR, Seyfried TN, Chinopoulos C (2024) Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia. Sci Rep 14:1729. https://doi.org/10.1038/s41598-024-51365-4MouseHeart
Liver
Fitzgerald 2024 J Cachexia Sarcopenia Muscle2024Fitzgerald LF, Lackey J, Moussa A, Shah SV, Castellanos AM, Khan S, Schonk M, Thome T, Salyers ZR, Jakkidi N, Kim K, Yang Q, Hepple RT, Ryan TE (2024) Chronic aryl hydrocarbon receptor activity impairs muscle mitochondrial function with tobacco smoking. https://doi.org/10.1002/jcsm.13439MouseSkeletal muscle
Al-Sabri 2024 Sci Rep2024Al-Sabri MH, Ammar N, Korzh S, Alsehli AM, Hosseini K, Fredriksson R, Mwinyi J, Williams MJ, Boukhatmi H, Schiöth HB (2024) Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. https://doi.org/10.1038/s41598-024-53446-wDrosophilaSkeletal muscle
Donnelly 2024 Redox Biol2024Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion A-C, Matera A, Tavernari D, Campiche O, Paolicelli RC, Zanou N, Kayser B, Gnaiger E, Place N (2024) Functional hypoxia reduces mitochondrial calcium uptake. Redox Biol 71:103037. https://doi.org/10.1016/j.redox.2024.103037Human
Mouse
Heart
Skeletal muscle
Cefis 2024 Acta Physiol (Oxf)2024Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, Gouspillou G (2024) MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiol (Oxf) [Epub ahead of print]. https://doi.org/10.1111/apha.14119MouseSkeletal muscle
Taylor 2024 Pilot Feasibility Stud2024Taylor MK, Burns JM, Choi IY, Herda TJ, Lee P, Smith AN, Sullivan DK, Swerdlow RH, Wilkins HM (2024) Protocol for a single-arm, pilot trial of creatine monohydrate supplementation in patients with Alzheimer's disease. Pilot Feasibility Stud 10:42. https://doi.org/10.1186/s40814-024-01469-5HumanLymphocyte
Platelet
Sorby-Adams 2024 Redox Biol2024Sorby-Adams A, Prime TA, Miljkovic JL, Prag HA, Krieg T, Murphy MP (2024) A model of mitochondrial superoxide production during ischaemia-reperfusion injury for therapeutic development and mechanistic understanding. Redox Biol 72:103161. https://doi.org/10.1016/j.redox.2024.103161RatHeart
Lhuissier 2024 iScience2024Lhuissier C, Desquiret-Dumas V, Girona A, Alban J, Faure J, Cassereau J, Codron P, Lenaers G, Baris OR, Gueguen N, Chevrollier A (2024) Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission. iScience 27:109808. https://doi.org/10.1016/j.isci.2024.109808MouseFibroblast
Noerregaard 2024 J Physiol2024Noerregaard LB, Hansen CC, Wickham KA, Moeller S, Olsen K, Ehlers T, Bangsbo J, Hellsten Y (2024) Exercise training alters skeletal muscle microvascular endothelial cell properties in recent postmenopausal females. J Physiol [Epub ahead of print]. https://doi.org/10.1113/jp286269HumanSkeletal muscle
Endothelial;epithelial;mesothelial cell
Dulac 2024 J Physiol2024Dulac M, Hajj-Boutros G, Sonjak V, Faust A, Hussain SNA, Chevalier S, Dionne IJ, Morais JA, Gouspillou G (2024) A multimodal exercise countermeasure prevents the negative impact of head-down tilt bed rest on muscle volume and mitochondrial health in older adults. J Physiol [Epub ahead of print]. https://doi.org/10.1113/jp285897HumanSkeletal muscle
Holwerda 2024 J Cachexia Sarcopenia Muscle2024Holwerda AM, Dirks ML, Barbeau PA, Goessens J, Gijsen A, van Loon LJC, Holloway GP (2024) Mitochondrial bioenergetics are not associated with myofibrillar protein synthesis rates. J Cachexia Sarcopenia Muscle [Epub ahead of print]. https://doi.org/10.1002/jcsm.13532Human
Mouse
Skeletal muscle
Coulson 2024 J Exp Biol2024Coulson SZ, Guglielmo CG, Staples JF (2024) Migration increases mitochondrial oxidative capacity without increasing reactive oxygen species emission in a songbird. J Exp Biol 227:jeb246849. https://doi.org/10.1242/jeb.246849BirdsSkeletal muscle
Meldau 2024 Mol Genet Metab Rep2024Meldau S, Ackermann S, Riordan G, van der Watt GF, Spencer C, Raga S, Khan K, Blackhurst DM, van der Westhuizen FH (2024) A novel mitochondrial DNA variant in MT-ND6: m.14430A>C p.(Trp82Gly) identified in a patient with Leigh syndrome and complex I deficiency. Mol Genet Metab Rep 39:101078. https://doi.org/10.1016/j.ymgmr.2024.101078HumanFibroblast
Czyzowska 2023 Redox Biol2023Czyżowska A, Brown J, Xu H, Sataranatarajan K, Kinter M, Tyrell VJ, O'Donnell VB, Van Remmen H (2023) Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. https://doi.org/10.1016/j.redox.2023.102761MouseSkeletal muscle
Dabrowska 2023 Int J Mol Sci2023Dabrowska A, Zajac M, Bednarczyk P, Lukasiak A (2023) Effect of quercetin on mitoBKCa channel and mitochondrial function in human bronchial epithelial cells exposed to particulate matter. Int J Mol Sci 24:638. https://doi.org/10.3390/ijms24010638HumanLung;gill
Endothelial;epithelial;mesothelial cell
Devaux 2023 J Comp Physiol B2023Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2023) Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae). https://doi.org/10.1007/s00360-023-01495-4FishesNervous system
Salmon 2023 Geroscience2023Salmón P, Millet C, Selman C, Monaghan P, Dawson NJ (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. https://doi.org/10.1007/s11357-022-00624-1BirdsSkeletal muscle
Liver
Koizumi 2023 Front Cardiovasc Med2023Koizumi T, Watanabe M, Yokota T, Tsuda M, Handa H, Koya J, Nishino K, Tatsuta D, Natsui H, Kadosaka T, Koya T, Nakao M, Hagiwara H, Kamada R, Temma T, Tanaka S, Anzai T (2023) Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats. Front Cardiovasc Med 10: 1005408.RatHeart
Leduc-Gaudet 2023 Nat Commun2023Leduc-Gaudet JP, Franco-Romero A, Cefis M, Moamer A, Broering FE, Milan G, Sartori R, Chaffer TJ, Dulac M, Marcangeli V, Mayaki D, Huck L, Shams A, Morais JA, Duchesne E, Lochmuller H, Sandri M, Hussain SNA, Gouspillou G (2023) MYTHO is a novel regulator of skeletal muscle autophagy and integrity. https://doi.org/10.1038/s41467-023-36817-1MouseSkeletal muscle
Donnelly 2023 MitoFit2023Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion AC, Matera A, Tavernari D, Zanou N, Kayser B, Gnaiger E, Place N (2023) Functional hypoxia reduces mitochondrial calcium uptake. MitoFit Preprints 2023.2. https://doi.org/10.26124/mitofit:2023-00022024-11-17 published in Redox Biol.Human
Mouse
Skeletal muscle
Heart
Nervous system
Other cell lines
Mahmoud 2023 Pharmacol Res2023Mahmoud AM, Kostrzewa M, Marolda V, Cerasuolo M, Maccarinelli F, Coltrini D, Rezzola S, Giacomini A, Mollica MP, Motta A, Paris D, Zorzano A, Marzo VD, Ronca R, Ligresti A (2023) Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer. https://doi.org/10.1016/j.phrs.2023.106683MouseEndothelial;epithelial;mesothelial cell
Gautam 2023 Neurobiol Dis2023Gautam M, Genç B, Helmold B, Ahrens A, Kuka J, Makrecka-Kuka M, Günay A, Koçak N, Aguilar-Wickings IR, Keefe D, Zheng G, Swaminathan S, Redmon M, Zariwala HA, Özdinler PH (2023) SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function. https://doi.org/10.1016/j.nbd.2023.106022RatHeart
Nervous system
Dominguez-Lopez 2023 Neuropharmacology2023Dominguez-Lopez S, Ahn B, Sataranatarajan K, Ranjit R, Premkumar P, Van Remmen H, Beckstead MJ (2023) Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione. https://doi.org/10.1016/j.neuropharm.2023.109436MouseNervous system
Fletcher 2023 Transl Res2023Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E, Wilkinson T, Ring A, Ferrer L, Haynatzki G, Smith RS, Bohannon WT, Koutakis P (2023) Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease. https://doi.org/10.1016/j.trsl.2023.05.002MouseSkeletal muscle
Som 2023 Am J Physiol Cell Physiol2023Som R, Fink BD, Yu L, Sivitz WI (2023) Oxaloacetate regulates complex II respiration in brown fat: dependence on UCP1 expression. Am J Physiol Cell Physiol 324:C1236-48. doi: 10.1152/ajpcell.00565.2022MouseFat
Steffen 2023 J Exp Biol2023Steffen JBM, Sokolov EP, Bock C, Sokolova IM (2023) Combined effects of salinity and intermittent hypoxia on mitochondrial capacity and reactive oxygen species efflux in the Pacific oyster, Crassostrea gigas. https://doi.org/10.1242/jeb.246164MolluscsLung;gill
Pharaoh 2023 Geroscience2023Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ (2023) The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT). https://doi.org/10.1007/s11357-023-00861-yMouseSkeletal muscle
Krause 2023 J Transl Med2023Krause J, Nickel A, Madsen A, Aitken-Buck HM, Stoter AMS, Schrapers J, Ojeda F, Geiger K, Kern M, Kohlhaas M, Bertero E, Hofmockel P, Hübner F, Assum I, Heinig M, Müller C, Hansen A, Krause T, Park DD, Just S, Aïssi D, Börnigen D, Lindner D, Friedrich N, Alhussini K, Bening C, Schnabel RB, Karakas M, Iacoviello L, Salomaa V, Linneberg A, Tunstall-Pedoe H, Kuulasmaa K, Kirchhof P, Blankenberg S, Christ T, Eschenhagen T, Lamberts RR, Maack C, Stenzig J, Zeller T (2023) An arrhythmogenic metabolite in atrial fibrillation. https://doi.org/10.1186/s12967-023-04420-zHumanHeart
Zvejniece 2023 Biomed Pharmacother2023Zvejniece L, Svalbe B, Vavers E, Ozola M, Grinberga S, Gukalova B, Sevostjanovs E, Liepinsh E, Dambrova M (2023) Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats.Rat
Batterson 2023 Physiol Rep2023Batterson PM, McGowan EM, Borowik AK, Kinter MT, Miller BF, Newsom SA, Robinson MM (2023) High-fat diet increases electron transfer flavoprotein synthesis and lipid respiration in skeletal muscle during exercise training in female mice. https://doi.org/10.14814/phy2.15840MouseSkeletal muscle
Stouth 2023 Autophagy2023Stouth DW, vanLieshout TL, Mikhail AI, Ng SY, Raziee R, Edgett BA, Vasam G, Webb EK, Gilotra KS, Markou M, Pineda HC, Bettencourt-Mora BG, Noor H, Moll Z, Bittner ME, Gurd BJ, Menzies KJ, Ljubicic V (2023) CARM1 drives mitophagy and autophagy flux during fasting-induced skeletal muscle atrophy. https://doi.org/10.1080/15548627.2023.2288528MouseSkeletal muscle
Davis 2023 Am J Physiol Regul Integr Comp Physiol .2023Davis MS, Bayly WM, Hansen CM, Barrett MR, Blake CA (2023) Effects of hyperthermia and acidosis on mitochondrial production of reactive oxygen species. Am J Physiol Regul Integr Comp Physiol . 325(6):R725-R734.HorseSkeletal muscle
Quemeneur 2022 Sci Rep2022Quéméneur JB, Danion M, Cabon J, Collet S, Zambonino-Infante JL, Salin K (2022) The relationships between growth rate and mitochondrial metabolism varies over time. https://doi.org/10.1038/s41598-022-20428-9FishesSkeletal muscle
Ceja-Galicia 2022 Antioxidants (Basel)2022Ceja-Galicia ZA, García-Arroyo FE, Aparicio-Trejo OE, El-Hafidi M, Gonzaga-Sánchez G, León-Contreras JC, Hernández-Pando R, Guevara-Cruz M, Tovar AR, Rojas-Morales P, Aranda-Rivera AK, Sánchez-Lozada LG, Tapia E, Pedraza-Chaverri J (2022) Therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia: association with the improvement of renal mitochondrial β-oxidation and lipid metabolism in kidney and liver. https://doi.org/10.3390/antiox11112195RatKidney
Brown 2022 Redox Biol2022Brown JL, Peelor FF 3rd, Georgescu C, Wren JD, Kinter M, Tyrrell VJ, O'Donnell VB, Miller BF, Van Remmen H (2022) Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. https://doi.org/10.1016/j.redox.2022.102518MouseSkeletal muscle
Xu 2022 Sci Adv2022Xu H, Ahn B, Van Remmen H (2022) Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation. https://doi.org/10.1126/sciadv.add7377MouseSkeletal muscle
Formiga-Jr 2022 J Vis Exp2022Formiga-Jr MA, Camacho-Pereira J (2022) Assessing mitochondrial function in sciatic nerve by high-resolution respirometry. https://doi.org/10.3791/63690MouseNervous system
Sarabhai 2022 Diabetologia2022Sarabhai T, Mastrototaro L, Kahl S, Bönhof GJ, Jonuscheit M, Bobrov P, Katsuyama H, Guthoff R, Wolkersdorfer M, Herder C, Meuth SG, Dreyer S, Roden M (2022) Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. https://doi.org/10.1007/s00125-022-05797-0HumanSkeletal muscle
Fat
McKenna 2022 J Appl Physiol (1985)2022McKenna CF, Salvador AF, Keeble AR, Khan NA, De Lisio M, Konopka AR, Paluska SA, Burd NA (2022) Muscle strength after resistance training correlates to mediators of muscle mass and mitochondrial respiration in middle-aged adults. https://doi.org/10.1152/japplphysiol.00186.2022HumanSkeletal muscle
VanLieshout 2022 Mol Metab2022vanLieshout TL, Stouth DW, Hartel NG, Vasam G, Ng SY, Webb EK, Rebalka IA, Mikhail AI, Graham NA, Menzies KJ, Hawke TJ, Ljubicic V (2022) The CARM1 transcriptome and arginine methylproteome mediate skeletal muscle integrative biology. https://doi.org/10.1016/j.molmet.2022.101555MouseSkeletal muscle
Smith 2022 J Pineal Res2022Smith KLM, Swiderska A, Lock MC, Graham L, Iswari W, Choudhary T, Thomas D, Kowash HM, Desforges M, Cottrell EC, Trafford AW, Giussani DA, Galli GLJ (2022) Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex-dependent manner. https://doi.org/10.1111/jpi.12821RatHeart
Jelenik 2022 Pharmacol Res2022Jelenik T, Kodde A, Pesta D, Phielix E, Oosting A, Rohbeck E, Dewidar B, Mastrototaro L, Trenkamp S, Keijer J, van der Beek EM, Roden M (2022) Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming. https://doi.org/10.1016/j.phrs.2022.106193MouseSkeletal muscle
Liver
Pileggi 2022 EBioMedicine2022Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SAL, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, Dent RRM, Harper ME (2022) Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. https://doi.org/10.1016/j.ebiom.2022.104192HumanSkeletal muscle
Belosludtseva 2022 Membranes (Basel)2022Belosludtseva NV, Pavlik LL, Belosludtsev KN, Saris NL, Shigaeva MI, Mironova GD (2022) The short-term opening of cyclosporin A-independent palmitate/Sr 2+-induced pore can underlie ion efflux in the oscillatory mode of functioning of rat liver mitochondria. https://doi.org/10.3390/membranes12070667RatLiver
Yamauchi 2022 Sci Rep2022Yamauchi Y, Nakamura A, Yokota T, Takahashi K, Kawata S, Tsuchida K, Omori K, Nomoto H, Kameda H, Cho KY, Anzai T, Tanaka S, Terauchi Y, Miyoshi H, Atsumi T (2022) Luseogliflozin preserves the pancreatic beta-cell mass and function in db/db mice by improving mitochondrial function. Sci Rep 12: 9740.MouseIslet cell;pancreas;thymus
Qvit 2022 Pharmaceuticals (Basel)2022Qvit N, Lin AJ, Elezaby A, Ostberg NP, Campos JC, Ferreira JCB, Mochly-Rosen D (2022) A selective inhibitor of cardiac troponin I phosphorylation by delta protein kinase C (δPKC) as a treatment for ischemia-reperfusion injury. https://doi.org/10.3390/ph15030271RatHeart
Pallag 2022 Int J Mol Sci2022Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. https://doi.org/10.3390/ijms23095111MouseLiver
Kidney
Komlodi 2022 BEC2022Komlódi T, Tretter L (2022) The protonmotive force – not merely membrane potential. Bioenerg Commun 2022.16. https://doi.org/10.26124/bec:2022-0016
Salyers 2022 JVS Vasc Sci2022Salyers ZR, Mariani V, Balestrieri N, Kumar RA, Vugman NA, Thome T, Villani KR, Berceli SA, Scali ST, Vasilakos G, Ryan TE (2022) S100A8 and S100A9 are elevated in chronically threatened ischemic limb muscle and induce ischemic mitochondrial pathology in mice. https://doi.org/10.1016/j.jvssci.2022.03.003Human
Mouse
Skeletal muscle
Starr 2022 Curr Res Physiol2022Starr VJ, Dzialowski EM (2022) Developing chicken cardiac muscle mitochondria are resistant to variations in incubation oxygen levels. https://doi.org/10.1016/j.crphys.2022.03.001ChickenHeart
Loughland 2022 J Exp Biol2022Loughland I, Lau GY, Jolly J, Seebacher F (2022) Rates of warming impact oxidative stress in zebrafish (Danio rerio).ZebrafishSkeletal muscle
Yoval-Sanchez 2022 Redox Biol2022Yoval-Sánchez B, Ansari F, James J, Niatsetskaya Z, Sosunov S, Filipenko P, Tikhonova IG, Ten V, Wittig I, Rafikov R, Galkin A (2022) Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart. https://doi.org/10.1016/j.redox.2022.102258MouseHeart
Nervous system
Lopes 2022 Int J Mol Sci2022Lopes JA, Collino F, Rodrigues-Ferreira C, Sampaio LDS, Costa-Sarmento G, Wendt CHC, Almeida FP, Miranda KR, Kasai-Brunswick TH, Lindoso RS, Vieyra A (2022) Early effects of extracellular vesicles secreted by adipose tissue mesenchymal cells in renal ischemia followed by reperfusion: mechanisms rely on a decrease in mitochondrial anion superoxide production. https://doi.org/10.3390/ijms23062906HumanKidney
Vandenberg 2022 Am J Physiol Cell Physiol2022Vandenberg GG, Thotakura A, Scott AL (2022) Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects. Am J Physiol Cell Physiol 322:C125-35. https://doi.org/10.1152/ajpcell.00130.2021MouseNervous system
Barath 2022 Int J Mol Sci2022Baráth B, Jász DK, Horváth T, Baráth B, Maróti G, Strifler G, Varga G, Sándor L, Perényi D, Tallósy S, Donka T, Jávor P, Boros M, Hartmann P (2022) Mitochondrial side effects of surgical prophylactic antibiotics Ceftriaxone and Rifaximin lead to bowel mucosal damage. Int J Mol Sci 23:5064. https://doi.org/10.3390/ijms23095064RatLiver
Hansen 2022 Free Radic Biol Med2022Hansen C, Møller S, Ehlers T, Wickham KA, Bangsbo J, Gliemann L, Hellsten Y (2022) Redox balance in human skeletal muscle-derived endothelial cells - Effect of exercise training. https://doi.org/10.1016/j.freeradbiomed.2021.12.265HumanEndothelial;epithelial;mesothelial cell
Cruz-Gregorio 2022 Antioxidants (Basel)2022Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2022) GK-1 Induces oxidative stress, mitochondrial dysfunction, decreased membrane potential, and impaired autophagy flux in a mouse model of breast cancer. https://doi.org/10.3390/antiox12010056MouseEndothelial;epithelial;mesothelial cell
Munro 2022 Mitochondrion2022Munro D, Rodríguez E, Blier PU (2022) The longest-lived metazoan, Arctica islandica, exhibits high mitochondrial H2O2 removal capacities. https://doi.org/10.1016/j.mito.2022.11.005MolluscsLung;gill
Endothelial;epithelial;mesothelial cell
MiPNet24.10 H2O2 flux analysis2021-10-22
O2k-Protocols
Hydrogen peroxide flux analysis using Amplex UltraRed assay in MiR05-Kit with DatLab 7.4
MiPNet26.10 MgG data analysis2021-09-16
O2k-Protocols
Measurement of mitochondrial ATP production using Magnesium Green: DL-Protocols and data analysis with DatLab 7.4
MiPNet17.05 O2k-Fluo LED2-Module2021-06-22
O2k-Manual
O2k-Fluo LED2-Module.
Christiansen 2021 Sci Rep2021Christiansen LB, Dohlmann TL, Ludvigsen TP, Parfieniuk E, Ciborowski M, Szczerbinski L, Kretowski A, Desler C, Tiano L, Orlando P, Martinussen T, Olsen LH, Larsen S (2021) Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected. Sci Rep 11:2167.PigHeart
Skeletal muscle
Liver
Yardeni 2021 Proc Natl Acad Sci U S A2021Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC (2021) An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proc Natl Acad Sci U S A 118:e2021429118.MouseNervous system
Thoral 2021 Biol Lett2021Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759.FishesSkeletal muscle
Furihata 2021 Commun Biol2021Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.MouseHeart
Salin 2021 Mar Environ Res2021Salin K, Mathieu-Resuge M, Graziano N, Dubillot E, Le Grand F, Soudant P, Vagner M (2021) The relationship between membrane fatty acid content and mitochondrial efficiency differs within- and between- omega-3 dietary treatments. Mar Environ Res 163:105205.FishesSkeletal muscle
Furihata 2021 BMC Pharmacol Toxicol2021Furihata T, Maekawa S, Takada S, Kakutani N, Nambu H, Shirakawa R, Yokota T, Kinugawa S (2021) Premedication with pioglitazone prevents doxorubicin-induced left ventricular dysfunction in mice. BMC Pharmacol Toxicol 22:27.MouseHeart
Cardoso 2021 BEC MgG2021Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. Bioenerg Commun 2021.1. https://doi.org/10.26124/bec:2021-0001MouseHeart
Deline 2021 Biochim Biophys Acta Bioenerg2021Deline ML, Grashei M, van Heijster FHA, Schilling F, Straub J, Fromme T (2021) Adenylate kinase derived ATP shapes respiration and calcium storage of isolated mitochondria. Biochim Biophys Acta Bioenerg 1862:148409.MouseLiver
Morgan 2021 Resuscitation2021Morgan RW, Sutton RM, Himebauch AS, Roberts AL, Landis WP, Lin Y, Starr J, Ranganathan A, Delso N, Mavroudis CD, Volk L, Slovis J, Marquez AM, Nadkarni VM, Hefti M, Berg RA, Kilbaugh TJ (2021) A randomized and blinded trial of inhaled nitric oxide in a piglet model of pediatric cardiopulmonary resuscitation. Resuscitation 162:274-83 .PigNervous system
Cheng 2021 Comp Biochem Physiol B Biochem Mol Biol2021Cheng H, Munro D, Huynh K, Pamenter ME (2021) Naked mole-rat skeletal muscle mitochondria exhibit minimal functional plasticity in acute or chronic hypoxia. Comp Biochem Physiol B Biochem Mol Biol 255:110596.Other mammalsSkeletal muscle
Dall 2021 J Biol Chem2021Dall M, Hassing AS, Niu L, Nielsen TS, Ingerslev LR, Sulek K, Trammell SAJ, Gillum MP, Barrès R, Larsen S, Poulsen SS, Mann M, Ørskov C, Treebak JT (2021) Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. J Biol Chem 297:101388.MouseLiver
Vandenberg 2021 Neurochem Int2021Vandenberg GG, Dawson NJ, Head A, Scott GR, Scott AL (2021) Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model. Neurochem Int 146:105036.MouseNervous system
Hansen 2021 Physiol Rep2021Hansen C, Olsen K, Pilegaard H, Bangsbo J, Gliemann L, Hellsten Y (2021) High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells. Physiol Rep 9:e14855.RatSkeletal muscle
Endothelial;epithelial;mesothelial cell
Apostolopoulou 2021 Sci Adv2021Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straßburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Müssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. https://doi.org/10.1126/sciadv.abi9551HumanSkeletal muscle
Pharaoh 2021 JCSM Rapid Commun2021Pharaoh G, Brown J, Ranjit R, Ungvari Z, Van Remmen H (2021) Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation. https://doi.org/10.1002/rco2.29MouseSkeletal muscle
Newsom 2021 Med Sci Sports Exerc2021Newsom SA, Stierwalt HD, Ehrlicher SE, Robinson MM (2021) Substrate-specific respiration of isolated skeletal muscle mitochondria after 1 h of moderate cycling in sedentary adults. https://doi.org/10.1249/mss.0000000000002615HumanSkeletal muscle
Jasz 2021 J Cell Mol Med2021Jász DK, Szilágyi ÁL, Tuboly E, Baráth B, Márton AR, Varga P, Varga G, Érces D, Mohácsi Á, Szabó A, Bozó R, Gömöri K, Görbe A, Boros M, Hartmann P (2021) Reduction in hypoxia-reoxygenation-induced myocardial mitochondrial damage with exogenous methane. https://doi.org/10.1111/jcmm.16498RatHeart
Elliehausen 2021 Exp Gerontol2021Elliehausen CJ, Minton DM, Nichol AD, Konopka AR (2021) Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin. https://doi.org/10.1016/j.exger.2021.111579Guinea pigSkeletal muscle
Sarabhai 2021 Diabetologia2021Sarabhai T, Koliaki C, Mastrototaro L, Kahl S, Pesta D, Apostolopoulou M, Wolkersdorfer M, Bönner AC, Bobrov P, Markgraf DF, Herder C, Roden M (2021) Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia 65:301-14.HumanSkeletal muscle
Galli 2021 Front Physiol2021Galli GLJ, Ruhr IM, Crossley J, Crossley DA 2nd (2021) The long-term effects of developmental hypoxia on cardiac mitochondrial function in snapping turtles. Front Physiol 12:689684. doi: 10.3389/fphys.2021.689684ReptilesHeart
Theall 2021 Physiol Rep2021Theall B, Stampley J, Cho E, Granger J, Johannsen NM, Irving BA, Spielmann G (2021) Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults. Physiol Rep 9:e15147.HumanBlood cells
Komlodi 2021 BEC AmR-O22021Komlódi T, Sobotka O, Gnaiger E (2021) Facts and artefacts on the oxygen dependence of hydrogen peroxide production using Amplex UltraRed. Bioenerg Commun 2021.4. https://doi.org/10.26124/bec:2021-0004Saccharomyces cerevisiaeOther cell lines
Riguet 2021 Nat Commun2021Riguet N, Mahul-Mellier AL, Maharjan N, Burtscher J, Croisier M, Knott G, Hastings J, Patin A, Reiterer V, Farhan H, Nasarov S, Lashuel HA (2021) Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nat Commun 12:6579.HumanHEK
Marrocco 2021 J Immunol2021Marrocco A, Frawley K, Pearce LL, Peterson J, O'Brien JP, Mullett SJ, Wendell SG, St Croix CM, Mischler SE, Ortiz LA (2021) Metabolic adaptation of macrophages as mechanism of defense against crystalline silica. J Immunol 207:1627-40.MouseMacrophage-derived
MiPNet24.08 Safranin Analysis Template2020-05-13
O2k-Protocols
Excel template for safranin data analysis.
MiPNet25.14 TPP Analysis Template2020-##-##
O2k-Protocols
Excel template for TPP data analysis.
Ponce 2020 J Am Heart Assoc2020Ponce JM, Coen G, Spitler KM, Dragisic N, Martins I, Hinton A Jr, Mungai M, Tadinada SM, Zhang H, Oudit GY, Song LS, Li N, Sicinski P, Strack S, Abel ED, Mitchell C, Hall DD, Grueter CE (2020) Stress-induced cyclin C translocation regulates cardiac mitochondrial dynamics. J Am Heart Assoc 9:e014366.Rat
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Li Puma 2020 Am J Physiol Regul Integr Comp Physiol2020Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:972-80.MouseHeart
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Fuller 2020 J Appl Physiol (1985)2020Fuller KNZ, McCoin CS, Allen J, Bell-Glenn S, Koestler DC, Dorn Ii GW, Thyfault JP (2020) Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice. J Appl Physiol (1985) 128:1251-61.MouseLiver
Zussman 2020 J Autoimmun2020Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437.HumanGenital
Hassan 2020 MitoFit Preprint Arch2020Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003Human
Aparicio-Trejo 2020 Free Radic Biol Med2020Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32.RatKidney
Brunetta 2020 J Physiol2020Brunetta HS, Politis-Barber V, Petrick HL, Dennis KMJH, Kirsh AJ, Barbeau PA, Nunes EA, Holloway GP (2020) Nitrate attenuates HFD-induced glucose intolerance in association with reduced epididymal adipose tissue inflammation and mitochondrial ROS emission. J Physiol 598:3357-71.MouseFat
Buch 2020 FASEB J2020Buch BT, Halling JF, Ringholm S, Gudiksen A, Kjøbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70.MouseSkeletal muscle
Lozano 2020 Part Fibre Toxicol2020Lozano O, Silva-Platas C, Chapoy-Villanueva H, Pérez BE, Lees JG, Ramachandra CJA, Contreras-Torres FF, Lázaro-Alfaro A, Luna-Figueroa E, Bernal-Ramírez J, Gordillo-Galeano A, Benitez A, Oropeza-Almazán Y, Castillo EC, Koh PL, Hausenloy DJ, Lim SY, García-Rivas G (2020) Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes. Part Fibre Toxicol 17:15.Rat
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Dirks 2020 J Physiol2020Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. J Physiol 598:123-37.HumanSkeletal muscle
Chausse 2020 Brain Behav Immun2020Chausse B, Lewen A, Poschet G, Kann O (2020) Selective inhibition of mitochondrial respiratory complexes controls the transition of microglia into a neurotoxic phenotype in situ. Brain Behav Immun 88:802-14.MouseNervous system
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Mendham 2020 Sci Rep2020Mendham Amy E, Larsen Steen, George Cindy, Adams Kevin, Hauksson Jon, Olsson Tommy, Fortuin-de Smidt Melony C, Nono Nankam Pamela A, Hakim Olah, Goff Louise M, Pheiffer Carmen, Goedecke Julia H (2020) Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Sci Rep 10:3785.Fat
Hafstad 2020 Antioxidants (Basel)2020Hafstad AD, Hansen SS, Lund J, Santos CXC, Boardman NT, Shah AM, Aasum E (2020) NADPH oxidase 2 mediates myocardial oxygen wasting in obesity. Antioxidants (Basel) 9:E171.MouseHeart
Ehrlicher 2020 FASEB J2020Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18.MouseSkeletal muscle
Szibor 2020 J Cell Mol Med2020Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gaertner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlueter KD, Jacobs HT(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48.MouseHeart
Hartmann 2020 Free Radic Res2020Hartmann DD, Gonçalves DF, Da Rosa PC, Martins RP, Courtes AA, Franco JL, A Soares FA, Puntel GO (2020) A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism. Free Radic Res 54:137-49.RatSkeletal muscle
Duong 2020 Mitochondrion2020Duong QV, Hoffman A, Zhong K, Dessinger MJ, Zhang Y, Bazil JN (2020) Calcium overload decreases net free radical emission in cardiac mitochondria. Mitochondrion 51:126-39.Guinea pigHeart
Purhonen 2020 Nat Commun2020Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.MouseLiver
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Hedges 2020 Biosci Rep2020Hedges CP, Pham T, Shetty B, Masson SWC, Hickey AJR, Shepherd PR, Merry TL (2020) Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function. https://doi.org/10.1042/bsr20201128MouseSkeletal muscle
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Baxter 2020 Elife2020Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705.MouseHeart
Oellermann 2020 Sci Rep2020Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202.CrustaceansHeart
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Mahul-Mellier 2020 Proc Natl Acad Sci U S A2020Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA (2020) The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci U S A 117:4971-82.MouseNervous system
Marquez 2020 J Am Heart Assoc2020Marquez AM, Morgan RW, Ko T, Landis WP, Hefti MM, Mavroudis CD, McManus MJ, Karlsson M, Starr J, Roberts AL, Lin Y, Nadkarni V, Licht DJ, Berg RA, Sutton RM, Kilbaugh TJ (2020) Oxygen exposure during cardiopulmonary resuscitation is associated with cerebral oxidative injury in a randomized, blinded, controlled, preclinical trial. J Am Heart Assoc 9:015032.PigNervous system
Burtscher 2020 eNeuro2020Burtscher J, Copin JC, Sandi C, Lashuel HA (2020) Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala. eNeuro 7:ENEURO.0110-20.2020.MouseNervous system
Makrecka-Kuka 2020 Sci Rep2020Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. https://doi.org/10.1038/s41598-020-78620-8.MouseEndothelial;epithelial;mesothelial cell
Gnaiger 2020 BEC MitoPathways2020Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002Human
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Skeletal muscle
Fibroblast
Charles 2020 Nanomedicine (Lond)2020Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) 15:2917-32.HumanEndothelial;epithelial;mesothelial cell
Kupats 2020 Oxid Med Cell Longev2020Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598.MouseNervous system
Kunz 2020 J Biol Chem2020Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem 295:17441-59.MouseSkeletal muscle
Avila-Rojas 2020 Food Chem Toxicol2020Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774.RatKidney
Olsen 2020 J Physiol2020Olsen LN, Hoier B, Hansen CV, Leinum M, Carter HH, Jorgensen TS, Bangsbo J, Hellsten Y (2020) Angiogenic potential is reduced in skeletal muscle of aged women. J Physiol 598:5149-64.HumanEndothelial;epithelial;mesothelial cell
Silva-Rodrigues 2020 Free Radic Biol Med2020Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med 160:796-806.RatNervous system
Mikulas 2020 Materials2020Mikulás K, Komlódi T, Földes A, Sváb G, Horváth G, Nagy AM, Ambrus A, Gyulai-Gaál Sz, Gera I, Hermann P, Varga G, Tretter L (2020) Bioenergetic Impairment of triethylene glycol dimethacrylate- (TEGDMA-) treated dental pulp stem cells (DPSCs) and isolated brain mitochondria are amended by redox compound methylene blue. Materials (Basel) 13(16):3472.Guinea pig
Human
Stem cells
Pham 2020 Eur J Appl Physiol2020Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.HumanSkeletal muscle
Bhaskaran 2020 Aging Cell2020Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225.MouseSkeletal muscle
Abid 2020 FASEB J2020Abid H, Ryan ZC, Delmotte P, Sieck GC, Lanza IR (2020) Extramyocellular interleukin-6 influences skeletal muscle mitochondrial physiology through canonical JAK/STAT signaling pathways. FASEB J 34:14458-72.MouseSkeletal muscle
Pharaoh 2020 Sci Rep2020Pharaoh G, Brown JL, Sataranatarajan K, Kneis P, Bian J, Ranjit R, Hadad N, Georgescu C, Rabinovitch P, Ran Q, Wren JD, Freeman W, Kinter M, Richardson A, Van Remmen H (2020) Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia. Sci Rep 10:13968.MouseSkeletal muscle
Souza da Silva 2020 Mol Neurobiol2020Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809.MouseNervous system
Smith 2020 J Biol Chem2020Smith CD, Schmidt CA, Lin CT, Fisher-Wellman KH, Neufer PD (2020) Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure. J Biol Chem 295:16207-16.MouseSkeletal muscle
Marrocco 2020 Thesis2020Marrocco A (2020) Alterations of CCSP expression and macrophages metabolism in the development of silica-induced pulmonary inflammation and fibrosis. PhD Thesis 108.MouseMacrophage-derived
Hernansanz-Agustin 2020 Nature2020Hernansanz-Agustín P, Choya-Foces C, Carregal-Romero S, Ramos E, Oliva T, Villa-Piña T, Moreno L, Izquierdo-Álvarez A, Cabrera-García JD, Cortés A, Lechuga-Vieco AV, Jadiya P, Navarro E, Parada E, Palomino-Antolín A, Tello D, Acín-Pérez R, Rodríguez-Aguilera JC, Navas P, Cogolludo Á, López-Montero I, Martínez-Del-Pozo Á, Egea J, López MG, Elrod JW, Ruíz-Cabello J, Bogdanova A, Enríquez JA, Martínez-Ruiz A (2020) Na+ controls hypoxic signalling by the mitochondrial respiratory chain. Nature 586:287-91.RatHeart
Davidson 2020 Circ Res2020Davidson MT, Grimsrud P, Lai L, Draper J, Fisher-Wellman KH, Narowski TM, Koves TR, Kelly DP, Muoio DM (2020) Extreme acetylation of the cardiac mitochondrial proteome does not promote heart failure. Circ Res 127:1094-108.MouseHeart
Le 2020 J Biol Chem2020Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ (2020) Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria. J Biol Chem 295:12485-97.HumanHeart
Dulac 2020 J Physiol2020Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710.MouseSkeletal muscle
Falcao-Tebas 2020 J Physiol2020Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70.RatSkeletal muscle
MiPNet24.11 mtMP calculation2019-08-05
O2k-Protocols
Mitochondrial membrane potential calculation
MiPNet18.05 Amplex-Mouse-heart2019-06-24
O2k-Protocols
O2k-Fluorometry: HRR and H2O2 production in mouse cardiac tissue homogenate.
MouseHeart
MiPNet20.13 Safranin mt-membranepotential2019-06-24
O2k-Protocols
O2k-FluoRespirometry: HRR and simultaneous determination of mt-membrane potential with safranin or TMRM.
MouseNervous system
MiPNet20.14 AmplexRed H2O2-production2019-06-24
O2k-Protocols
O2k-FluoRespirometry: HRR and simultaneous determination of H2O2 production with Amplex UltraRed.
MouseHeart
Halling 2019 Am J Physiol Endocrinol Metab2019Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525.MouseSkeletal muscle
Naszai 2019 Sci Rep2019Nászai A, Terhes E, Kaszaki J, Boros M, Juhász L (2019) Ca(2+)N it be measured? Detection of extramitochondrial calcium movement with high-resolution FluoRespirometry. Sci Rep 9:19229.RatLiver
Holsgrove 2019 Thesis2019Holsgrove A (2019) The effect of temperature on cardiac energetics in the rainbow trout, Onchorhynchus mykiss. Phd Thesis 166.FishesHeart
Ponce 2019 Thesis2019Ponce JM (2019) Investigating the roles of cyclin C in the mammalian heart. PhD Thesis 137.MouseHeart
Devaux 2019 Front Physiol2019Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2019) Acidosis maintains the function of brain mitochondria in hypoxia-tolerant triplefin fish: a strategy to survive acute hypoxic exposure? Front Physiol 9:1941.FishesNervous system
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis2019Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.HumanFibroblast
Robinson 2019 Am J Physiol Cell Physiol2019Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol 317:C339-C347.Mouse
Rat
Skeletal muscle
Stepanova 2019 Antioxid Redox Signal2019Stepanova Anna, Sosunov S, Niatsetskaya Z, Konrad Csaba, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal 31:608-22.MouseNervous system
Miotto 2019 FASEB J2019Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40.HumanSkeletal muscle
Power 2019 PLoS One2019Power AS, Norman R, Jones TLM, Hickey AJ, Ward ML (2019) Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment. PLoS One 14:e0214740.RatHeart
Bundgaard 2019 Sci Rep2019Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A (2019) Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury. Sci Rep 9:2850.Mouse
Reptiles
Heart
Munro 2019 Aging Cell2019Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916.Mouse
Other mammals
Heart
Skeletal muscle
Scheiber 2019 Exp Mol Med2019Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J (2019) High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure. Exp Mol Med 51:16.HumanHeart
Ahn 2019 J Cachexia Sarcopenia Muscle2019Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28.MouseSkeletal muscle
Courtes 2019 Biomed Pharmacother2019Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca2+-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111:1438-46.RatLiver
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol2019Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21.Other invertebratesSkeletal muscle
McBride 2019 Arch Biochem Biophys2019McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.MouseSkeletal muscle
Laouafa 2019 Acta Physiol (Oxf)2019Laouafa S, Roussel D, Marcouiller F, Soliz J, Gozal D, Bairam A, Joseph V (2019) Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats. Acta Physiol (Oxf) 226:e13255.RatNervous system
Rajendran 2019 EMBO Mol Med2019Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456.MouseLiver
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Lefranc 2019 Hypertension2019Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68.MouseFat
Spinazzi 2019 Proc Natl Acad Sci U S A2019Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86. 10.1073/pnas.1811938116MouseNervous system
Monteiro 2019 J Bioenerg Biomembr2019Monteiro J, Assis-de-Lemos G, de-Souza-Ferreira E, Marques AM, Neves GA, Silveira MS, Galina A (2019) Energization by multiple substrates and calcium challenge reveal dysfunctions in brain mitochondria in a model related to acute psychosis. J Bioenerg Biomembr 52:1-15.MouseNervous system
Isei 2019 Free Radic Biol Med2019Isei MO, Kamunde C (2019) Effects of copper and temperature on heart mitochondrial hydrogen peroxide production. Free Radic Biol Med 147:114-28.FishesHeart
Skrivergaard 2019 Viruses2019Skrivergaard S, Jensen MS, Rolander TB, Nguyen TBN, Bundgaard A, Nejsum LN, Martensen PM (2019) The cellular localization of the p42 and p46 oligoadenylate synthetase 1 isoforms and their impact on mitochondrial respiration. Viruses 11:E1122.HumanOther cell lines
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Szibor 2019 Biochim Biophys Acta Bioenerg2019Szibor Marten, Gainutdinov Timur, Fernandez-Vizarra Erika, Dufour Eric, Gizatullina Zemfira, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Viscomi Carlo, Gellerich Frank Norbert, Moore Anthony L (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137.MouseHeart
Pharaoh 2019 Mol Neurobiol2019Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31.MouseSkeletal muscle
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Cannon 2019 J Appl Physiol (1985)2019Cannon DT, Rodewohl L, Adams V, Breen EC, Bowen TS (2019) Skeletal myofiber VEGF deficiency leads to mitochondrial, structural and contractile alterations in mouse diaphragm. J Appl Physiol (1985) 127:1360-69.MouseSkeletal muscle
McMurray 2019 FASEB J2019McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME (2019) Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. FASEB J 33:13515-26.MouseSkeletal muscle
Ederle 2019 J Clin Med2019Ederle C, Charles AL, Khayath N, Poirot A, Meyer A, Clere-Jehl R, Andres E, De Blay F, Geny B (2019) Mitochondrial function in peripheral blood mononuclear cells (PBMC) is enhanced, together with increased reactive oxygen species, in severe asthmatic patients in exacerbation. J Clin Med 8:E1613.HumanBlood cells
Salin 2019 Proc Biol Sci2019Salin K, Villasevil EM, Anderson GJ, Lamarre SG, Melanson CA, McCarthy I, Selman C, Metcalfe NB (2019) Differences in mitochondrial efficiency explain individual variation in growth performance. Proc Biol Sci 286:20191466.FishesSkeletal muscle
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Perry 2019 J Mol Cell Cardiol2019Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171.RatHeart
Shirakawa 2019 Sci Rep2019Shirakawa R, Yokota T, Nakajima T, Takada S, Yamane M, Furihata T, Maekawa S, Nambu H, Katayama T, Fukushima A, Saito A, Ishimori N, Dela F, Kinugawa S, Anzai T (2019) Mitochondrial reactive oxygen species generation in blood cells is associated with disease severity and exercise intolerance in heart failure patients. Sci Rep 9:14709.HumanBlood cells
Ruegsegger 2019 JCI Insight2019Ruegsegger GN, Vanderboom PM, Dasari S, Klaus KA, Kabiraj P, McCarthy CB, Lucchinetti CF, Nair KS (2019) Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain. JCI Insight 4:130681.MouseNervous system
Ruegsegger 2019 FASEB J2019Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS (2019) Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J 33:4458-72.MouseNervous system
Rojas-Morales 2019 Free Radic Biol Med2019Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med 135:60-67.RatKidney
Axton 2019 J Nutr2019Axton ER, Beaver LM, St Mary L, Truong L, Logan CR, Spagnoli S, Prater MC, Keller RM, Garcia-Jaramillo M, Ehrlicher SE, Stierwalt HD, Newsom SA, Robinson MM, Tanguay RL, Stevens JF, Hord NG (2019) Treatment with nitrate, but not nitrite, lowers the oxygen cost of exercise and decreases glycolytic intermediates while increasing fatty acid metabolites in exercised zebrafish. J Nutr 00:1–13.ZebrafishSkeletal muscle
Cooper 2019 Exp Physiol2019Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2019) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12.MouseNervous system
Seo 2019 Exp Neurol2019Seo JH, Park HS, Park SS, Kim CJ, Kim DH, Kim TW (2019) Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder. Exp Neurol 322:113043.RatNervous system
Hernansanz-Agustin 2019 bioRxiv2019Hernansanz-Agustín P, Choya-Foces C, Carregal-Romero S, Ramos E, Oliva T, Villa-Piña T, Moreno L, Izquierdo-Álvarez A, JCabrera-García JD, Cortés A, Lechuga-Vieco AV, Jadiya P, Navarro E, Parada E, Palomino-Antolín A, Tello D, Acín-Pérez R, Rodríguez-Aguilera JC, Navas P, Cogolludo A, López-Montero I, Martínez-del-Pozo A, Egea J, López MG, Elrod JW, Ruiz-Cabello J, Bogdanova A, Enríquez JA, Martínez-Ruiz A (2019) Mitochondrial Na+ import controls oxidative phosphorylation and hypoxic redox signalling. bioRxiv doi: https://doi.org/10.1101/385690.Rat
Bovines
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Pileggi 2018 Free Radic Biol Med2018Pileggi CA, Hedges CP, D'Souza RF, Durainayagam BR, Markworth JF, Hickey AJR, Mitchell CJ, Cameron-Smith D (2018) Exercise recovery increases skeletal muscle H2O2 emission and mitochondrial respiratory capacity following two-weeks of limb immobilization. Free Radic Biol Med 124:241-8.HumanSkeletal muscle
Karlsson 2018 J Neurotrauma2018Karlsson M, Pukenas B, Chawla S, Ehinger JK, Plyler R, Stolow M, Gabello M, Hugerth M, Elmér E, Hansson MJ, Margulies S, Kilbaugh T (2018) Neuroprotective effects of cyclosporine in a porcine pre-clinical trial of focal traumatic brain injury. J Neurotrauma 36:14-24.PigNervous system
Burney 2018 Thesis2018Burney E (2018) Characterization of mitochondrial metabolism in L6 rat myoblasts. Bachelor's Thesis p50.RatOther cell lines
Jelenik 2018 Mol Metab2018Jelenik T, Dille M, Müller-Lühlhoff S, Kabra DG, Zhou Z, Binsch C, Hartwig S, Lehr S, Chadt A, Peters EMJ, Kruse J, Roden M, Al-Hasani H, Castañeda TR (2018) FGF21 regulates insulin sensitivity following long-term chronic stress. Mol Metab 16:126-38.MouseSkeletal muscle
Cooper 2018 Exp Physiol2018Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2018) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12.MouseNervous system
Logan 2018 Thesis2018Logan C (2018) Nitrate and nitrite differentially affect respiration in zebrafish during exercise. Honors Baccalaureate of Science in Nutrition p44.ZebrafishSkeletal muscle
Kim 2018 Free Radic Biol Med2018Kim M, Stepanova A, Niatsetskaya Z, Sosunov S, Arndt S, Murphy MP, Galkin A, Ten VS (2018) Attenuation of oxidative damage by targeting mitochondrial complex I in neonatal hypoxic-ischemic brain injury. Free Radic Biol Med 124:517-24.MouseNervous system
Kamunde 2018 Free Radic Biol Med2018Kamunde C, Sharaf M, MacDonald N (2018) H2O2 metabolism in liver and heart mitochondria: Low emitting-high scavenging and high emitting-low scavenging systems. Free Radic Biol Med 124:135-48.FishesHeart
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Robb 2018 J Biol Chem2018Robb EL, Hall AR, Prime TA, Eaton S, Szibor M, Viscomi C, James AM, Murphy MP (2018) Control of mitochondrial superoxide production by reverse electron transport at complex I. J Biol Chem 293:9869-79. https://doi.org/10.1074/jbc.RA118.003647RatHeart
Ravasz 2018 Biochim Biophys Acta2018Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2018) Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding NAD+ supports substrate-level phosphorylation during respiratory inhibition. Biochim Biophys Acta 1859:909-24.MouseLiver
Salin 2018 Funct Ecol2018Salin K, Villasevil EM, Anderson GJ, Auer SK, Selman C, Hartley RC, Mullen W, Chinopoulos C, Metcalfe NB (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Funct Ecol DOI: 10.1111/1365-2435.13125.FishesLiver
Komlodi 2018 Methods Mol Biol2018Komlodi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E (2018) Comparison of mitochondrial incubation media for measurement of respiration and hydrogen peroxide production. Methods Mol Biol 1782:137-55.Human
Mouse
Skeletal muscle
HEK
Ahn 2018 Redox Biol2018Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H (2018) Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol 17:47-58.MouseSkeletal muscle
Scheiber 2018 J Cardiovasc Transl Res2018Scheiber D, Zweck E, Jelenik T, Horn P, Albermann S, Masyuk M, Boeken U, Saeed D, Kelm M Roden M, Szendroedi J, Westenfeld R (2018) Reduced myocardial mitochondrial ROS production in mechanically unloaded hearts. J Cardiovasc Transl Res 12:107-15.HumanHeart
Holloway 2018 Cell Rep2018Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018) Age-associated impairments in mitochondrial ADP sensitivity contribute to redox stress in senescent human skeletal muscle. Cell Rep 22:2837–48.HumanSkeletal muscle
Smenes 2018 Interact Cardiovasc Thorac Surg2018Smenes BT, Bækkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, Høydal M, Wisløff U, Rognmo Ø, Wahba A (2018) Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg 27:95-101.HumanHeart
Jang 2018 Intensive Care Med Exp2018Jang DH, MD, Khatri UG, Shortal BP, Kelly M, Lambert DS, Hardy K, Eckmann DM (2018) Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 6:4.HumanBlood cells
Mavroudis 2018 Eur J Cardiothorac Surg2018Mavroudis CD, Karlsson M, Ko T, Hefti M, Gentile JI, Morgan RW, Plyler R, Mensah-Brown KG, Boorady TW, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Nicolson SC, Spray TL, Sutton RM, Berg RA, Licht DJ, Gaynor JW, Kilbaugh TJ (2018) Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest in neonatal swine. Eur J Cardiothorac Surg 54:162-68.PigNervous system
Jang 2018 J Med Toxicol2018Jang DH, Khatri UG, Mudan A, Love JS, Owiredu S, Eckmann DM (2018) Translational application of measuring mitochondrial functions in blood cells obtained from patients with acute poisoning. J Med Toxicol 14:144-51.HumanBlood cells
Treberg 2018 Comp Biochem Physiol B Biochem Mol Biol2018Treberg JR, Braun K, Zacharias P, Kroeker K (2018) Multidimensional mitochondrial energetics: Application to the study of electron leak and hydrogen peroxide metabolism. Comp Biochem Physiol B Biochem Mol Biol 224:121-28.Mouse
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Du 2018 Environ Sci Technol2018Du SNN, McCallum ES, Vaseghi-Shanjani M, Choi JA, Warriner TR, Balshine S, Scott GR (2018) Metabolic costs of exposure to wastewater effluent lead to compensatory adjustments in respiratory physiology in bluegill sunfish. Environ Sci Technol 52:801-11.FishesLiver
Thrush 2018 Int J Obes (Lond)2018Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack R, Al-Dirbashi OY, Dent R, McPherson R, Harper ME (2018) Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism. Int J Obes (Lond) 42:353-62.HumanSkeletal muscle
Dawson 2018 Acta Physiol (Oxf)2018Dawson NJ, Lyons SA, Henry DA, Scott GR (2018) Effects of chronic hypoxia on diaphragm function in deer mice native to high altitude. Acta Physiol (Oxf) 223:e13030.Other mammalsSkeletal muscle
Larsen 2018 Physiol Rep2018Larsen S, Lundby AM, Dandanell S, Oberholzer L, Keiser S, Andersen AB, Haider T, Lundby C (2018) Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males. Physiol Rep 6:e13793.HumanSkeletal muscle
Falcao-Tebas 2018 J Physiol2018Falcão-Tebas F, Kuang J, Arceri C, Kerris JP, Andrikopoulos S, Marin EC, McConell GK (2018) Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by paternal high fat diet. J Physiol 597:121-36.RatSkeletal muscle
Dogan 2018 Cell Metab2018Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C (2018) Perturbed redox signaling exacerbates a mitochondrial myopathy. Cell Metab 28:764-77.MouseSkeletal muscle
Komlodi 2018 J Bioenerg Biomembr2018Komlódi T, Geibl FF, Sassani M, Ambrus A, Tretter L (2018) Membrane potential and delta pH dependency of reverse electron transport-associated hydrogen peroxide production in brain and heart mitochondria. J Bioenerg Biomembr 50:355-365Guinea pigHeart
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Stepanova 2018 J Neurochem2018Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A (2018) The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. J Neurochem 148:731-45.MouseNervous system
Hedges 2018 FASEB J2018Hedges CP, Bishop DJ, Hickey AJR (2018) Voluntary wheel running prevents the acidosis-induced decrease in skeletal muscle mitochondrial reactive oxygen species emission. FASEB J 33:4996-5004.RatSkeletal muscle
Goncalves 2018 Neurotoxicology2018Gonçalves DF, Courtes AA, Hartmann DD, da Rosa PC, Oliveira DM, Soares FAA, Dalla Corte CL (2018) 6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat. Neurotoxicology 70:1-11.RatNervous system
Campbell 2018 Free Radic Biol Med2018Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, Qian WJ, Marcinek DJ (2018) Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic Biol Med 134:268-81.MouseSkeletal muscle
Souza 2018 Sci Rep2018Souza RWA, Alves CRR, Medeiros A, Rolim N, Silva GJJ, Moreira JBN, Alves MN, Wohlwend M, Gebriel M, Hagen L, Sharma A, Koch LG, Britton SL, Slupphaug G, Wisløff U, Brum PC (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Sci Rep 8:17772.RatHeart
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Valentine 2018 J Gerontol A Biol Sci Med Sci2018Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N (2018) NFκB regulates muscle development and mitochondrial function. J Gerontol A Biol Sci Med Sci 75:647-53.MouseSkeletal muscle
Treberg 2018 Redox Biol2018Treberg JR, Braun K, Selseleh P (2018) Mitochondria can act as energy-sensing regulators of hydrogen peroxide availability. Redox Biol 20:483-88.RatSkeletal muscle
Holland 2018 Cell Death Dis2018Holland OJ, Cuffe JSM, Dekker Nitert M, Callaway L, Kwan Cheung KA, Radenkovic F, Perkins AV (2018) Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery. Cell Death Dis 9:1150.HumanGenital
Schiffer 2018 PLoS One2018Schiffer TA, Christensen M, Gustafsson H, Palm F (2018) The effect of inactin on kidney mitochondrial function and production of reactive oxygen species. PLoS One 13:e0207728.RatKidney
Aparicio-Trejo 2018 Free Radic Biol Med2018Aparicio-Trejo OE, Reyes-Fermín LM, Briones-Herrera A, Tapia E, León-Contreras JC, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2018) Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radic Biol Med 130:379-96.RatKidney
Jelenik 2018 Diabetes2018Jelenik T, Flögel U, Álvarez-Hernández E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, Knebel B, Müller-Wieland D, Moellendorf S, Gödecke A, Kelm M, Westenfeld R, Roden M, Szendroedi J (2018) Insulin resistance and vulnerability to cardiac ischemia. Diabetes 67:2695-702.Human
Mouse
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Nielsen 2018 Neurosci Lett2018Nielsen B, Cejvanovic V, Wörtwein G, Hansen AR, Marstal KK, Weimann A, Bjerring PN, Dela F, Poulsen HE, Jørgensen MB (2018) Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. Neurosci Lett 690:1-5.RatNervous system
Trewin 2018 Am J Physiol Regul Integr Comp Physiol2018Trewin AJ, Parker L, Shaw CS, Hiam D, Garnham AP, Levinger I, McConell GK, Stepto NK (2018) Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration and cell signaling as endurance exercise even with less work. Am J Physiol Regul Integr Comp Physiol 315:R1003-R1016.HumanSkeletal muscle
Stepanova 2018 J Cereb Blood Flow Metab2018Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A (2018) Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain. J Cereb Blood Flow Metab 39:1790-802.RatNervous system
Kjeld 2018 PLoS One2018Kjeld T, Stride N, Gudiksen A, Hansen EG, Arendrup HC, Horstmann PF, Zerahn B, Jensen LT, Nordsborg N, Bejder J, Halling JF (2018) Oxygen conserving mitochondrial adaptations in the skeletal muscles of breath hold divers. PLoS One 13:e0201401.HumanSkeletal muscle
Run DL-Protocol/Set O2 limit2017-08-10
MitoPedia
Online documentation of DL-Protocol function of DatLab7.
Michalak 2017 Oxid Med Cell Longev2017Michalak S, Florczak-Wyspiańska J, Rybacka-Mossakowska J, Ambrosius W, Osztynowicz K, Baszczuk A, Kozubski W, Wysocka E (2017) Mitochondrial respiration in intact peripheral blood mononuclear cells and sirtuin 3 activity in patients with movement disorders. Oxid Med Cell Longev 2017:9703574.Blood cells
Xiong 2017 J Am Heart Assoc2017Xiong S, Wang B, Lin S, Zhang H, Li Y, Wei X, Cui Y, Wei X, Lu Z, Gao P, Li L, Zhao Z, Liu D, Zhu Z (2017) Activation of transient receptor potential melastatin subtype 8 attenuates cold-induced hypertension through ameliorating vascular mitochondrial dysfunction. J Am Heart Assoc 6. pii: e005495.MouseEndothelial;epithelial;mesothelial cell
Trewin 2017 PLOS ONE2017Trewin AJ, Levinger I, Parker L, Shaw CS, Serpiello FR, Anderson MJ, McConell GK, Hare DL, Stepto NK (2017) Acute exercise alters skeletal muscle mitochondrial respiration and H2O2 emission in response to hyperinsulinemic-euglycemic clamp in middle-aged obese men. PLOS ONE 12:e0188421.HumanSkeletal muscle
Mahalingam 2017 J Physiol2017Mahalingam S, McClelland GB, Scott GR (2017) Evolved changes in the intracellular distribution and physiology of muscle mitochondria in high-altitude native deer mice. J Physiol 595:4785-801.MouseSkeletal muscle
Jang 2017 Biol Open2017Jang DH, Seeger SC, Grady ME, Shofer FC, Eckmann DM (2017) Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biol Open 6:1831-9.HumanEndothelial;epithelial;mesothelial cell
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Sharaf 2017 Aquat Toxicol2017Sharaf MS, Stevens D, Kamunde C (2017) Zinc and calcium alter the relationship between mitochondrial respiration, ROS and membrane potential in rainbow trout (Oncorhynchus mykiss) liver mitochondria. Aquat Toxicol 189:170-83.FishesLiver
Sharaf 2017 Biochim Biophys Acta2017Sharaf MS, Stevens D, Kamunde C (2017) Mitochondrial transition ROS spike (mTRS) results from coordinated activities of complex I and nicotinamide nucleotide transhydrogenase. Biochim Biophys Acta 1858:955-65.Mouse
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Cardoso 2017 Biochim Biophys Acta2017Cardoso GMF, Pletsch JT, Parmeggiani B, Grings M, Glanzel NM, Bobermin LD, Amaral AU, Wajner M, Leipnitz G (2017) Bioenergetics dysfunction, mitochondrial permeability transition pore opening and lipid peroxidation induced by hydrogen sulfide as relevant pathomechanisms underlying the neurological dysfunction characteristic of ethylmalonic encephalopathy. Biochim Biophys Acta 1863:2192-2201.RatNervous system
Newsom 2017 Am J Physiol Endocrinol Metab2017Newsom SA, Miller BF, Hamilton KL, Ehrlicher SE, Stierwalt HD, Robinson MM (2017) Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. Am J Physiol Endocrinol Metab 313:552-62.MouseSkeletal muscle
Du 2017 Evolution2017Du SNN, Khajali F, Dawson NJ, Scott GR (2017) Hybridization increases mitochondrial production of reactive oxygen species in sunfish. Evolution 71:1643-52.FishesLiver
Napa 2017 Int J Dent2017Napa K, Baeder AC, Witt JE, Rayburn ST, Miller MG, Dallon BW, Gibbs JL, Wilcox SH, Winden DR, Smith JH, Reynolds PR, Bikman BT (2017) LPS from P. gingivalis negatively alters gingival cell mitochondrial bioenergetics. Int J Dent 2017:2697210.HumanEndothelial;epithelial;mesothelial cell
Lopez-Manzano 2017 Chem Res Toxicol2017Lopez-Manzano E, Cronican AA, Frawley KL, Peterson J, Pearce LL (2017) Cyanide scavenging by a cobalt Schiff-base macrocycle: a cost-effective alternative to corrinoids. Chem Res Toxicol 29:1011-9.
Ravasz 2017 Neurochem Int2017Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2017) Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation. Neurochem Int 109:41-53.MouseNervous system
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Khalifa 2017 Physiol Rep2017Khalifa AR, Abdel-Rahman EA, Mahmoud AM, Ali MH, Noureldin M, Saber SH, Mohsen M, Ali SS (2017) Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain. Physiol Rep 5. pii: e13125.MouseHeart
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Makrecka-Kuka 2017 Toxicol Lett2017Makrecka-Kuka M, Volska K, Antone U, Vilskersts R, Grinberga S, Bandere D, Liepinsh E, Dambrova M (2017) Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicol Lett 267:32-8.MouseHeart
Djordjevic 2017 Neuroscience2017Djordjevic J, Thomson E, Chowdhury SR, Snow WM, Perez C, Wong TP, Fernyhough P, Albensi BC (2017) Brain region- and sex-specific alterations in mitochondrial function and NF-κB signaling in the TgCRND8 mouse model of Alzheimer's disease. Neuroscience 361:81-92.MouseNervous system
Nemeth 2017 Thesis2017Németh B (2017) The effect of itaconic acid on mitochondrial substrate-level phosphorylation. PhD Thesis p84.MouseLiver
De Moura 2017 Neurotox Res2017de Moura Alvorcem L, da Rosa MS, Glänzel NM, Parmeggiani B, Grings M, Schmitz F, Wyse ATS, Wajner M, Leipnitz G (2017) Disruption of energy transfer and redox status by sulfite in hippocampus, striatum, and cerebellum of developing rats. Neurotox Res 32:264-75.RatNervous system
De Carvalho 2017 Toxicol Research2017de Carvalho NR, Rodrigues NR, Macedo GE, Boligon AA, de Campos MM, Posser T, Cunha FAB, Coutinho HD, Klamt F, Bristot IJ, Merritt TJS, Franco JL (2017) Eugenia uniflora leaves essential oil promotes mitochondrial dysfunction in Drosophila melanogaster through the inhibition of oxidative phosphorylation. Toxicol Research 6:526-34 .Drosophila
Herbst 2017 Appl Physiol Nutr Metab2017Herbst EAF, George MAJ, Brebner K, Holloway GP, Kane DA (2017) Lactate is oxidized outside of the mitochondrial matrix in rodent brain. Appl Physiol Nutr Metab 43:467-74.Mouse
Rat
Nervous system
Koning 2017 J Cereb Blood Flow Metab2017Koning G, Leverin AL, Nair S, Schwendimann L, Ek J, Carlsson Y, Gressens P, Thornton C, Wang X, Mallard C, Hagberg H (2017) Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection. J Cereb Blood Flow Metab 39:1038-55.Rat
Lau 2017 Dissertation2017Lau G (2017) Adaptive variation of mitochondrial function in response to oxygen variability in intertidal sculpins (Cottidae, Actinopterygii). Dissertation p148.FishesNervous system
Goedecke 2017 JMIR Res Protoc2017Goedecke JH, Mendham AE, Clamp L, Nono Nankam PA, Fortuin-de Smidt MC, Phiri L, Micklesfield LK, Keswell D, Woudberg NJ, Lecour S, Alhamud A, Kaba M, Lutomia FM, van Jaarsveld PJ, de Villiers A, Kahn SE, Chorell E, Hauksson J, Olsson T (2017) An exercise intervention to unravel the mechanisms underlying insulin resistance in a cohort of black South African women: Protocol for a randomized controlled trial. JMIR Res Protoc 03/10/2017:9098.HumanSkeletal muscle
Fat
Briston 2017 Sci Rep2017Briston T, Roberts M, Lewis S, Powney B, M Staddon J, Szabadkai G, Duchen MR (2017) Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability. Sci Rep 7:10492.RatLiver
Stepanova 2017 J Cereb Blood Flow Metab2017Stepanova A, Kahl A, Konrad C, Ten V, Starkov AS, Galkin A (2017) Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia-reperfusion injury. J Cereb Blood Flow Metab 37:3649-58.MouseNervous system
Chowdhury 2015 Biosci Rep2016Chowdhury SK, Djordjevic J, Albensi B, Fernyhough P (2015) Simultaneous evaluation of substrate-dependent oxygen consumption rates and mitochondrial membrane potential by TMRM and safranin in cortical mitochondria. Biosci Rep 36:e00286.MouseNervous system
Nemeth 2016 FASEB J2016Németh B, Doczi J, Csete D, Kacso G, Ravasz D, Adams D, Kiss G, Nagy AM, Horvath G, Tretter L, Mócsai A, Csépányi-Kömi R, Iordanov I, Adam-Vizi V, Chinopoulos C (2016) Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. FASEB J 30:286-300.MouseLiver
Bouitbir 2016 Antioxid Redox Signal2016Bouitbir J, Singh F, Charles AL, Schlagowski AI, Bonifacio A, Echaniz-Laguna A, Geny B, Krähenbühl S, Zoll J (2016) Statins trigger mitochondrial ROS-induced apoptosis in glycolytic skeletal muscle. Antioxid Redox Signal 24:84-98.RatSkeletal muscle
Other cell lines
Du 2016 J Exp Biol2016Du SN, Mahalingam S, Borowiec BG, Scott GR (2016) Mitochondrial physiology and reactive oxygen species production are altered by hypoxia acclimation in killifish (Fundulus heteroclitus). J Exp Biol 219:1130-8.FishesLiver
Liepinsh 2016 Biochem J2016Liepinsh E, Makrecka-Kuka M, Volska K, Kuka J, Makarova E, Antone U, Sevostjanovs E, Vilskersts R, Strods A, Tars K, Dambrova M (2016) Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria. Biochem J 473:1191-202.RatHeart
Karlsson 2016 Shock2016Karlsson M, Hara N, Morata S, Sjövall F, Kilbaugh T, Hansson MJ, Uchino H, Elmér E (2016) Diverse and tissue-specific mitochondrial respiratory response in a mouse model of sepsis-induced multiple organ failure. Shock 45:404-10.MouseNervous system
Liver
Salin 2016 Physiol Rep2016Salin K, Villasevil EM, Auer SK, Anderson GJ, Selman C, Metcalfe NB, Chinopoulos C (2016) Simultaneous measurement of mitochondrial respiration and ATP production in tissue homogenates and calculation of effective P/O ratios. Physiol Rep 10.14814/phy2.13007.FishesLiver
Abdel-Rahman 2016 Oxid Med Cell Longev2016Abdel-Rahman EA, Mokhtar A, Aaliya A, Radwan Y, Yasseen B, Al-Okda A, Atwa A, Elhanafy E, Habashy M, Ali SS (2016) Resolving contributions of oxygen-consuming and ROS-generating enzymes at the synapse. Oxid Med Cell Longev p19.MouseNervous system
Larsen 2016 FASEB J2016Larsen FJ, Schiffer TA, Ørtenblad N, Zinner C, Morales-Alamo D, Willis SJ, Calbet JA, Holmberg HC, Boushel R (2016) High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation. FASEB J 30:417-27.HumanSkeletal muscle
Mezera 2016 Oxid Med Cell Longev2016Mezera V, Endlicher R, Kucera O, Sobotka O, Drahota Z, Cervinkova Z (2016) Effects of epigallocatechin gallate on tert-butyl hydroperoxide-induced mitochondrial dysfunction in rat liver mitochondria and hepatocytes. Oxid Med Cell Longev 7573131:8pp.RatLiver
Timpani 2016 Neurotherapeutics2016Timpani CA, Trewin AJ, Stojanovska V, Robinson A, Goodman CA, Nurgali K, Betik AC, Stepto N, Hayes A, McConell GK, Rybalka E (2016) Attempting to compensate for reduced neuronal nitric oxide synthase protein with nitrate supplementation cannot overcome metabolic dysfunction but rather has detrimental effects in Dystrophin-deficient mdx muscle. Neurotherapeutics 14:429-46.MouseSkeletal muscle
Schiffer 2016 Am J Physiol Cell Physiol2016Schiffer TA, Peleli M, Sundqvist ML, Ekblom B, Lundberg JO, Weitzberg E, Larsen FJ (2016) Control of human energy expenditure by cytochrome c oxidase subunit IV-2. Am J Physiol Cell Physiol 311:C452-61.HumanSkeletal muscle
HEK
Power 2016 Am J Physiol Heart Circ Physiol2016Power AS, Pham T, Loiselle DS, Crossman DH, Ward ML, Hickey AJ (2016) Impaired ADP channeling to mitochondria and elevated reactive oxygen species in hypertensive hearts. https://doi.org/10.1152/ajpheart.00050.2016RatHeart
Shirey 2016 Biochemistry2016Shirey K, Stover KR, Cleary J, Hoang N, Hosler J (2016) Membrane-anchored cyclic peptides as effectors of mitochondrial oxidative phosphorylation. Biochemistry 55:2100-11.RatHeart
Liver
Du 2015 J Biol Chem2015Du J, Rountree A, Cleghorn WM, Contreras L, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Satrustegui J, Kanow M, Chan L, Tsang SH, Sweet IR, Hurley JB (2015) Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina. J Biol Chem 291:4698-710.MouseNervous system
Islet cell;pancreas;thymus
Kluckova 2015 Cell Death Dis2015Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749.Other mammalsLung;gill
Other cell lines
Fibroblast
Makrecka-Kuka 2015 Biomolecules2015Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. https://doi.org/10.3390/biom5031319Human
Mouse
Heart
Nervous system
HEK
Krumschnabel 2015 Methods Mol Biol2015Krumschnabel G, Fontana-Ayoub M, Sumbalova Z, Heidler J, Gauper K, Fasching M, Gnaiger E (2015) Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. Methods Mol Biol 1264:245-61. https://doi.org/10.1007/978-1-4939-2257-4_22MouseNervous system
Elustondo 2014 Biochim Biophys Acta2014Elustondo PA, Negoda A, Kane CL, Kane DA, Pavlov EV (2014) Spermine selectively inhibits high-conductance, but not low-conductance calcium-induced permeability transition pore. Biochim Biophys Acta 1847:231–40.RatLiver
Kiss 2014 FASEB J2014Kiss G, Konrad C, Pour-Ghaz I, Mansour JJ, Németh B, Starkov AA, Adam-Vizi V, Chinopoulos C (2014) Diaphorases provide NAD+ in anoxia. FASEB J 28:1682-97.MouseLiver
Krumschnabel 2014 Methods Enzymol2014Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81. https://doi.org/10.1016/B978-0-12-416618-9.00009-1MouseNervous system
Chinopoulos 2014 Methods Enzymol2014Chinopoulos C, Kiss G, Kawamata H, Starkov AA (2014) Measurement of ADP-ATP exchange in relation to mitochondrial transmembrane potential and oxygen consumption. Methods Enzymol 542:333-48. doi:10.1016/B978-0-12-416618-9.00017-0HumanHEK
Pham 2014 Am J Physiol2014Pham T, Loiselle D, Power A, Hickey AJ (2014) Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart. Am J Physiol 307:C499–507.RatHeart
Iftikar 2014 Thesis University of Auckland2014Iftikar FI (2014) Testing the role of heart mitochondrial stability and function in heart failure of ectotherms exposed to heat stress. Thesis University of Auckland:167pp.FishesHeart
Soltysinska 2014 PLoS One2014Soltysinska E, Bentzen BH, Barthmes M, Hattel H, Thrush AB, Harper ME, Qvortrup K, Larsen FJ, Schiffer TA, Losa-Reyna J, Straubinger J, Kniess A, Thomsen MB, Brüggemann A, Fenske S, Biel M, Ruth P, Wahl-Schott C, Boushel RC, Olesen SP, Lukowski R (2014) KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. PLoS One 9:e103402.MouseHeart
Skeletal muscle
Kukat 2014 PLoS Genet2014Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Kunz WS, Trifunovic A (2014) Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity. https://doi.org/10.1371/journal.pgen.1004385MouseHeart
Hunter 2014 PhD Thesis2014Hunter FW (2014) Old target; new paradigm: Determinants of sensitivity to hypoxia-directed anticancer prodrugs. PhD Thesis:1-353.Other mammalsCHO
Gnaiger 2014 MitoPathways2014
O2k-Protocols
Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. Oroboros MiPNet Publications, Innsbruck:80 pp. — see 5th edition: Gnaiger 2020 BEC MitoPathways.
Human
Mouse
Heart
Skeletal muscle
Fibroblast
Reilly 2013 J Exp Biol2013Reilly BD, Hickey AJ, Cramp RL, Franklin CE (2013) Decreased hydrogen peroxide production and mitochondrial respiration in skeletal muscle but not cardiac muscle of the green-striped burrowing frog, a natural model of muscle disuse. J Exp Biol 217:1087-93.AmphibiansHeart
Skeletal muscle
Jelenik 2013 Eur Heart J2013Jelenik T, Floegel U, Phielix E, Kaul K, Nowotny P, Partke HP, Schrader J, Roden M, Szendroedi S (2013) Non-alcoholic fatty liver disease and insulin resistance are associated with increased cardiac oxidative stress in mice. Eur Heart J 34:P5045.MouseHeart
Hara 2013 Eur J Anaesthesiol2013Hara N, Karlsson M, Sjövall F, Hansson Magnus J, Elmér E, Uchino H (2013) Early brain mitochondrial dysfunction in a mouse model of sepsis: 7AP4‐9. Eur J Anaesthesiol 30,112-112.MouseNervous system
Iftikar 2013 PLoS One2013Iftikar FI, Hickey AJ (2013) Do mitochondria limit hot fish hearts? Understanding the role of mitochondrial function with heat stress in Notolabrus celidotus. PLoS One 8:e64120.FishesHeart
Hickey 2012 J Comp Physiol B2012Hickey AJ, Renshaw GM, Speers-Roesch B, Richards JG, Wang Y, Farrell AP, Brauner CJ (2012) A radical approach to beating hypoxia: depressed free radical release from heart fibers of the hypoxia-tolerant epaulette shark (Hemiscyllum ocellatum). J Comp Physiol B 182:91-100.FishesHeart
Gnaiger 2012 Mitochondr Physiol Network Bioblast 20122012
Oroboros
Gnaiger E, Meissner B, Laner V, eds (2012) Bioblast 2012: Mitochondrial Competence. Mitochondr Physiol Network 17.12. Oroboros MiPNet Publications, Innsbruck:96 pp. ISBN 978-3-9502399-5-9
Hunter 2012 Biochem Pharmacol2012Hunter FW, Wang J, Patel R, Hsu HL, Hickey AJ, Hay MP, Wilson WR (2012) Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: Comparison with other hypoxia-activated prodrugs. Biochem Pharmacol 83:574–85.CHO
O2k-Publications in the MiPMap

O2k-Publications: O2k-FluoRespirometry - Abstracts

Sort in ascending/descending order by a click on one of the small symbols in squares below.
 Has titleOrganismTissue;cell
Strich 2023 MiPschool Obergurgl
MiPsociety
Bioenergetic profiling of kinase inhibitors reveals drug off-targer effects in colon cancer cell models
Saleem 2023 MiPschool Obergurgl
MiPsociety
Mitochondrial physiology in cardiac muscle of deer mice native to high altitude.
MouseHeart
Schmitt 2023 BPS2023 San Diego
Erich Gnaiger
Schmitt S, Cardoso LHD, Cecatto C, Komlodi T, Gnaiger Erich (2023) Mitochondrial bioenergetics – a quantitative analytical and diagnostic approach. 67th Annual Meeting of the Biophysical Society.
Schmitt 2022 EBEC
Sabine Schmitt
Schmitt S, Gnaiger E (2022) Short-term effect of molecular hydrogen on mitochondrial respiration and hydrogen peroxide production in permeabilized HEK 293T cells. EBEC 2022.
HumanHEK
Cecatto 2022 EBEC
Cristiane Cecatto
Cecatto C, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is lower than calcium retention capacity in the presence and absence of cyclosporin A. EBEC 2022.
MouseLiver
Komlodi 2022 Abstract Bioblast3.1. «10+5»
Komlodi Timea
Komlódi Timea, Tretter L (2022) The protonmotive force – not merely membrane potential. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
»MitoFit Preprint« »Watch the presentation«
Kolonics 2022 Abstract BioblastP16.
Kolonics Attila
Kolonics Attila, Léner V, Kutasi B, Kutasi J (2022) Effects of Scenedesmus rubescens extract on Paraquat induced parkinsonism model in SH-SY5Y cells and mitochondrial dysfunction. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
MouseNervous system
Cecatto 2022 Abstract Bioblast5.1. «10+5»
Cecatto Cristiane
Cecatto Cristiane, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is lower than calcium retention capacity in the presence and absence of cyclosporin A. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Watch the presentation«
MouseLiver
Doerrier 2020 PaduaMuscleDaysDoerrier C, Di Marcello M, Gnaiger E (2020) Commitment to reproducibility in targeting mitochondrial respiratory control: basic and advanced applications of the O2k-FluoRespirometer. PaduaMuscleDays.Skeletal muscle
Blood cells
Rodriguez 2019 Abstract IOC141Rodriguez E, Camus FM, Lane N (2019) Mitochondria as “flux capacitors”: the effect of mitonuclear incompatibilities on mitochondrial physiology, metabolomics profile and gene expression in D. melanogaster. Mitochondr Physiol Network 24.02.Drosophila
Blier 2019 MiP2019
Pierre Blier
The secrets of extreme longevity from bivalves.
Molluscs
Sobotka 2018 MiP2018
Ondrej Sobotka
Measurement of ROS production under hypoxia and unexpected methodological pitfalls of Amplex UltraRed assay.
Mouse
Saccharomyces cerevisiae
Heart
Nervous system
Stelfa 2018 MiP2018
MiPsociety
Neuroprotective compound R-phenibut protects brain mitochondria against anoxia-reoxygenation damage in vitro.
RatNervous system
Komlodi 2018b EBEC2018Endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria.MouseLiver
Chicco 2018 MiP2018a
Adam J Chicco
Maternal aging increases granulosa cell mitochondrial ROS release and reduces oocyte OXPHOS-linked respiration: implications for embryo development.
HorseGenital
Komlodi 2018 EBEC2018Electron supply to the Q-junction: assessment of mitochondrial respiration, H2O2 flux and the redox state of the Q-pool.MouseNervous system
Doerrier 2018 EBEC2018
Carolina Anneliese Doerrier
Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.
Human
Mouse
Heart
Nervous system
Blood cells
HEK
Platelet
Nickel 2018 IOC130Defects in mitochondrial calcium uptake precede defects of the respiratory chain in X-linked Barth syndrome cardiomyopathy.MouseHeart
Fischer 2018 MiPschool Tromso E2
Christine Fischer
Analysis of mitochondrial function in iron deficiency anemia and iron overload conditions.
MouseHeart
Nervous system
Liver
Huete-Ortega 2018 MiPschool Tromso E2High-resolution respirometry: new perspectives for the study of bioenergetics in algae and plants.Plants
Gnaiger 2018 AussieMitKomlodi Timea, Sobotka Ondrej, Doerrier Carolina, Gnaiger Erich (2018) Mitochondrial H2O2 production is low under tissue normoxia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU.Mouse
Saccharomyces cerevisiae
Heart
Nervous system
Ravasz 2018 Abstract The evolving concept of mitochondriaVast pools of endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria.MouseLiver
Cardoso 2018 MiPschool Tromso E2
Luiza Helena Cardoso
Concomitant respiration and ATP production measurements to analyse P»/O2 ratios at physiological normoxia.
Chang 2018 Life Sciences Meeting 2018 Innsbruck ATpH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.HumanHEK
Kidney
Doerrier 2018 ESCI2018
Carolina Anneliese Doerrier
High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease
Human
Mouse
Heart
Skeletal muscle
Nervous system
Blood cells
HEK
Garipi 2018 MiPschool Tromso E2Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS productionHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Hellgren 2017 MiPschool Obergurgl
Kim Hellgren IMG 4885.JPG
Effect of prenatal hypoxia on adult mitochondrial respiration and ROS production.
MouseHeart
Bufe 2017 TRACT PhD project abstractMetabolic profiles in normal, dysplastic and cancerous oral cells.HumanOther cell lines
Doerrier 2017 Abstract MitoEAGLE Barcelona
COST Action MitoEAGLE
SUIT reference protocol for comparative mitochondrial physiology.
Human
Mouse
Heart
Nervous system
HEK
Hartmann 2017 Abstract MITOEAGLE Barcelona
COST Action MITOEAGLE
Mitochondrial respiration of isolated peripheral blood mononuclear cells in an experimental porcine brain injury model.
Human
Pig
Blood cells
Komlodi 2017 Abstract MITOEAGLE Barcelona
COST Action MitoEAGLE
Succinate dehydrogenase regulation via oxaloacetate in brain mitochondria.
Guinea pig
Mouse
Nervous system
Kidney
Heart
Liver
Komlodi 2017 MiPschool Obergurgl
Timea Komlodi
Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H2O2 production.
MouseNervous system
Doerrier 2017 MiPschool C2
DoerrierC.JPG
Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.
Human
Mouse
Heart
Nervous system
HEK
Panajatovic 2017 IOC124Role of PGC-1α associated mitochondrial biogenesis in statin-induced myotoxicity.MouseSkeletal muscle
Doerrier 2016b Abstract Mito Xmas Meeting InnsbruckSearching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.MouseHeart
Sumbalova 2016 Abstract Mito Xmas Meeting InnsbruckMethods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.MouseNervous system
Komlodi 2016 Abstract IOC116Komlodi T, Geibl F, Sassani M, Adam-Vizi V, Tretter L (2016) The effect of ΔΨmt and ΔpH on mitochondrial reactive oxygen species production - A comparative study using mitochondria isolated from different mammalian tissues. Mitochondr Physiol Network 21.11Guinea pigHeart
Skeletal muscle
Nervous system
Nielsen 2016 Abstract IOC116Nielsen B, Woertwein G, Cejvanovic V, Hansen AR, Weimann A, Bjerring PN, Poulsen HE, Joergensen MB (2016) The function of mitochondria and oxidative stress after antidepressants treatment in rats. Mitochondr Physiol Network 21.11RatNervous system
Gnaiger 2016 Abstract SFRR Australasia 2016Facts and artefacts in measurements of H2O2 production under hypoxia.Saccharomyces cerevisiae
Krumschnabel 2016b Abstract MitoFit Science Camp 2016O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.HumanKidney
HEK
Chicco 2016a Abstract MitoFit Science Camp 2016Oxygen dependence of H2O2 release from skeletal muscle and cardiac mitochondria: influence of sample preparation.MouseHeart
Skeletal muscle
Abdel-Rahman 2015 Abstract MiPschool Cape Town 2015Assessment of NADPH-dependent oxygen consumption and hydrogen peroxide production by high-resolution respirometry and EPR spectroscopy.Human
Mouse
Nervous system
Smenes 2015 Abstract IOC100Smenes BT, Baekkerud FH, Hassel E, Wohlwend M, Slagsvold KH, Rognmo O, Wahba A (2015) Mitochondrial function in patients exercising prior to coronary surgery – A single blinded randomized controlled trial. Mitochondr Physiol Network 20.01.HumanSkeletal muscle
Gnaiger 2015 Abstract MiP2015Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.HumanHEK
Laner 2015 Abstract MiPschool Cape Town 2015The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.Mouse
Saccharomyces cerevisiae
Heart
Bezuidenhout 2015 Abstract MiPschool Cape Town 2015A study of the effects of fructose feeding & exercise on SIRT 3 regulation in skeletal muscle.Rat
Madlala 2015 Abstract MiPschool Cape Town 2015Fructose-induced ROS production: The role of uric acid and transforming growth factor (TGF)-β1.HumanLiver
Other cell lines
Hoppel 2015 Abstract MiPschool London 2015Human blood cell types as study models of mitochondrial respiration and H2O2 production.HumanBlood cells
Sumbalova 2015 Abstract MiP2015High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods.MouseNervous system
Doerrier 2015 Abstract MiP2015Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.MouseHeart
Rohlena 2015 Abstract MiP2015Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.HumanOther cell lines
Ali 2015 Abstract MiP2015Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor!MouseHeart
Nervous system
Doerrier 2015 Abstract MiPschool Greenville 2015"Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k.MouseHeart
Kluckova 2014 Abstract MiP2014Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.Other cell lines
Komlodi 2014 Abstract MiP2014Methylenblue, an enhancer of mitochondrial substrate-level phosphorylation.Guinea pigNervous system
Hickey 2014 Abstract MiP2014Mitochondrial inefficiencies and anoxic ATP hydrolysis capacities in diabetic rat heart.RatHeart
Power 2014 Abstract MiP2014The hot heart: cardiac mitochondrial energetics during hyperthermia.RatHeart
Perry 2014 Abstract MiP2014Evaluation of critical experimental parameters for assessing mitochondrial bioenergetics in permeabilized myofibers.HumanSkeletal muscle
Meszaros 2014 Abstract MiP2014Methodological aspects of assessing mitochondrial function in small intestinal mucosal samples of rats and guinea pigs.Rat
Guinea pig
Krumschnabel 2014 Abstract MiP2014Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.MouseNervous system
Kressig 2013 Abstract IOC79Kressig F (2013) et al. Mechanism of increased pulmonary vascular remodeling in UCP2 k/o mice. Mitochondr Physiol Network 18.07MouseLung;gill
Other cell lines
Hickey 2013 Abstract MiP2013Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08.Other mammals
Fishes
Heart
Jezek 2013 Abstract MiP2013Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.MouseLung;gill
Islet cell;pancreas;thymus
Krumschnabel 2013 Abstract MiP2013Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.Mouse
Fishes
Heart
Nervous system
Liver
Laner 2013 ASMRMLaner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013.MouseHeart
Stoeger 2012 Abstract BioblastStoeger H, Fontana-Ayoub M, Eigentler A, Gnaiger E (2012) Cell respiration with yeast as a model. Mitochondr Physiol Network 17.12.Saccharomyces cerevisiae
Fungi
Horvath 2012 Abstract BioblastHorvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12.MouseHeart
Konrad 2012 Abstract BioblastKonrad C, Kiss G, Torocsik B, Adam-Vizi V, Chinopoulos C (2012) Absence of Ca2+-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in C. crangon and P. serratus. Mitochondr Physiol Network 17.12.Artemia
Crustaceans
Kiss 2012 Abstract BioblastKiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C (2012) The negative impact of alpha-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. Mitochondr Physiol Network 17.12.MouseNervous system
Liver
Fasching 2012 Abstract BioblastFasching M, Sumbalova Z, Gnaiger E (2012) O2k-Fluorometry - a MitoCom project. Mitochondr Physiol Network 17.12.MouseNervous system
Cervinkova 2012 Abstract BioblastCervinkova Z, Stankova P, Cervinka M, Kucera O, Drahota Z (2012) Evaluation of mitochondrial functions – an important tool for experimental hepatology. Mitochondr Physiol Network 17.12.RatLiver
Sumbalova 2011 Abstract KagoshimaSumbalova Z, Harrison DK, Gradl P, Fasching M, Gnaiger E (2011) Mitochondrial membrane potential, coupling control, H2O2 production, and the upper limit of mitochondrial performance. Abstract Kagoshima.MouseNervous system
Fasching 2011 Abstract BerlinFasching M, Harrison DK, Tretter L, Gnaiger E (2011) Combination of high-resolution respirometry and fluorometry for continuous monitoring of hydrogen peroxide production by mitochondria with resolution in the nanomolar range. Abstract Berlin.MouseNervous system


MitoPedia methods: Respirometry, Fluorometry 


MitoPedia O2k and high-resolution respirometry: O2k hardware, O2k-Open Support, O2k-Respirometry, O2k-FluoRespirometry 


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HRR: O2k-Fluorometer 


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