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O2k-Publications: Aging; senescence

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O2k-Publications: Aging; senescence

O2k-Publications in the MiPMap

»O2k-Publications: Topics

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 YearReferenceOrganismTissue;cell
Qiao 2024 J Sport Health Sci2024Qiao YS, Blackwell TL, Cawthon PM, Coen PM, Cummings SR, Distefano G, Farsijani S, Forman DE, Goodpaster BH, Kritchevsky SB, Mau T, Toledo FGS, Newman AB, Glynn NW (2024) Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA). https://doi.org/10.1016/j.jshs.2024.02.001HumanSkeletal muscle
Cefis 2024 Acta Physiol (Oxf)2024Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, Gouspillou G (2024) MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiol (Oxf) [Epub ahead of print]. https://doi.org/10.1111/apha.14119MouseSkeletal muscle
Fernando 2023 Commun Biol2023Fernando R, Shindyapina AV, Ost M, Santesmasses D, Hu Y, Tyshkovskiy A, Yim SH, Weiss J, Gladyshev VN, Grune T, Castro JP (2023) Downregulation of mitochondrial metabolism is a driver for fast skeletal muscle loss during mouse aging. https://doi.org/10.1038/s42003-023-05595-3MouseSkeletal muscle
Martell 2023 Acta Neuropathol Commun2023Martell E, Kuzmychova H, Senthil H, Kaul E, Chokshi CR, Venugopal C, Anderson CM, Singh SK, Sharif T (2023) Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations. https://doi.org/10.1186/s40478-023-01604-yHumanNervous system
Salmon 2023 Geroscience2023SalmĂłn P, Millet C, Selman C, Monaghan P, Dawson NJ (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. https://doi.org/10.1007/s11357-022-00624-1BirdsSkeletal muscle
Liver
Pharaoh 2023 Geroscience2023Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ (2023) The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT). https://doi.org/10.1007/s11357-023-00861-yMouseSkeletal muscle
Czyzowska 2023 Redox Biol2023CzyĆŒowska A, Brown J, Xu H, Sataranatarajan K, Kinter M, Tyrell VJ, O'Donnell VB, Van Remmen H (2023) Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. https://doi.org/10.1016/j.redox.2023.102761MouseSkeletal muscle
Thompson 2023 Geroscience2023Thompson SD, Barrett KL, Rugel CL, Redmond R, Rudofski A, Kurian J, Curtin JL, Dayanidhi S, Lavasani M (2023) Sex-specific preservation of neuromuscular function and metabolism following systemic transplantation of multipotent adult stem cells in a murine model of progeria. https://doi.org/10.1007/s11357-023-00892-5MouseSkeletal muscle
Silaidos 2023 Geroscience2023Silaidos CV, Reutzel M, Wachter L, Dieter F, Ludin N, Blum WF, Wudy SA, Matura S, Pilatus U, Hattingen E, Pantel J, Eckert GP (2023) Age-related changes in energy metabolism in peripheral mononuclear blood cells (PBMCs) and the brains of cognitively healthy seniors. https://doi.org/10.1007/s11357-023-00810-9HumanBlood cells
Menail 2023 FASEB J2023Menail HA, Cormier SB, LĂ©ger A, Robichaud S, Hebert-Chatelain E, Lamarre SG, Pichaud N (2023) Age-related flexibility of energetic metabolism in the honey bee Apis mellifera. https://doi.org/10.1096/fj.202300654rHexapods
Fisar 2023 Biomedicines2023Fiơar Z, Hroudová J, Zvěƙová M, Jirák R, Raboch J, Kitzlerová E (2023) Age-dependent alterations in platelet mitochondrial respiration. https://doi.org/10.3390/biomedicines11061564HumanPlatelet
Kyriazis 2023 Res Sq2023Kyriazis G, Serrano J, Boyd J, Mason C, Smith K, Karolyi K, Kondo S, Brown I, Maurya S, Meshram N, Serna V, Gilger J, Branch D, Gardell S, Baskin K, Ayala J, Pratley R, Goodpaster B, Coen P (2023) The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness. https://doi.org/10.21203/rs.3.rs-2475555/v1MouseSkeletal muscle
Diaz 2023 Front Mol Biosci2023Diaz EC, Adams SH, Weber JL, Cotter M, Bþrsheim E (2023) Elevated LDL-C, high blood pressure, and low peak V˙O2 associate with platelet mitochondria function in children-The Arkansas Active Kids Study. Front Mol Biosci 10:1136975. https://doi.org/10.3389/fmolb.2023.1136975HumanBlood cells
Platelet
Inoue 2023 Sci Rep2023Inoue R, Miura M, Yanai S, Nishimune H (2023) Coenzyme Q10 supplementation improves the motor function of middle-aged mice by restoring the neuronal activity of the motor cortex. https://doi.org/10.1038/s41598-023-31510-1Nervous system
Englund 2022 Mol Metab2022Englund DA, Jolliffe A, Aversa Z, Zhang X, Sturmlechner I, Sakamoto AE, Zeidler JD, Warner GM, McNinch C, White TA, Chini EN, Baker DJ, van Deursen JM, LeBrasseur NK (2022) p21 induces a senescence program and skeletal muscle dysfunction. https://doi.org/10.1016/j.molmet.2022.101652MouseSkeletal muscle
Xu 2022 Sci Adv2022Xu H, Ahn B, Van Remmen H (2022) Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation. https://doi.org/10.1126/sciadv.add7377MouseSkeletal muscle
Lu 2022 J Cosmet Dermatol2022Lu Q, Zou LF, Gao YZ, Ye T, Li MJ, Zhang YK, Liang B, Sun W, Xing DM (2022) Liquiritigenin reverses skin aging by inhibiting UV-induced mitochondrial uncoupling and excessive energy consumption. https://doi.org/10.1111/jocd.15506HumanEndothelial;epithelial;mesothelial cell
Munro 2022 Mitochondrion2022Munro D, RodrĂ­guez E, Blier PU (2022) The longest-lived metazoan, Arctica islandica, exhibits high mitochondrial H2O2 removal capacities. https://doi.org/10.1016/j.mito.2022.11.005MolluscsLung;gill
Endothelial;epithelial;mesothelial cell
Jedlicka 2022a Physiol Res2022Jedlička J, TĆŻma Z, Razak K, Kunc R, Kala A, Proskauer Pena S, Lerchner T, JeĆŸek K, KuncovĂĄ J (2022) Impact of aging on mitochondrial respiration in various organs. https://doi.org/10.33549/physiolres.934995RatHeart
Skeletal muscle
Nervous system
Liver
Kidney
Platelet
Kataura 2022 Dev Cell2022Kataura T, Sedlackova L, Otten EG, Kumari R, Shapira D, Scialo F, Stefanatos R, Ishikawa KI, Kelly G, Seranova E, Sun C, Maetzel D, Kenneth N, Trushin S, Zhang T, Trushina E, Bascom CC, Tasseff R, Isfort RJ, Oblong JE, Miwa S, Lazarou M, Jaenisch R, Imoto M, Saiki S, Papamichos-Chronakis M, Manjithaya R, Maddocks ODK, Sanz A, Sarkar S, Korolchuk VI (2022) Autophagy promotes cell survival by maintaining NAD levels. https://doi.org/10.1016/j.devcel.2022.10.008MouseFibroblast
Ahn 2022 Aging Cell2022Ahn B, Ranjit R, Kneis P, Xu H, Piekarz KM, Freeman WM, Kinter M, Richardson A, Ran Q, Brooks SV, Van Remmen H (2022) Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging Cell 21:e13569.MouseSkeletal muscle
Soares 2022 Geroscience2022Soares RN, Ramirez-Perez FI, Cabral-Amador FJ, Morales-Quinones M, Foote CA, Ghiarone T, Sharma N, Power G, Smith JA, Rector RS, Martinez-Lemus LA, Padilla J, Manrique-Acevedo C (2022) SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice. https://doi.org/10.1007/s11357-022-00563-xMouseEndothelial;epithelial;mesothelial cell
Hong 2022 Cell Stem Cell2022Hong X, Isern J, Campanario S, Perdiguero E, Ramírez-Pardo I, Segalés J, Hernansanz-Agustín P, Curtabbi A, Deryagin O, Pollån A, Gonzålez-Reyes JA, Villalba JM, Sandri M, Serrano AL, Enríquez JA, Muñoz-Cånoves P (2022) Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. https://doi.org/10.1016/j.stem.2022.07.009MouseSkeletal muscle
Branicky 2022 Sci Adv2022Branicky R, Wang Y, Khaki A, Liu JL, Kramer-Drauberg M, Hekimi S (2022) Stimulation of RAS-dependent ROS signaling extends longevity by modulating a developmental program of global gene expression. https://doi.org/10.1126/sciadv.adc9851Caenorhabditis elegans
Gnaiger 2021 MitoFit BCA2021Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. MitoFit Preprints 2021.08. https://doi.org/10.26124/mitofit:2021-0008HumanFibroblast
Furihata 2021 Commun Biol2021Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.MouseHeart
Sladowska 2021 PLoS Biol2021Sladowska M, Turek M, Kim MJ, Drabikowski K, Mussulini BHM, Mohanraj K, Serwa RA, Topf U, Chacinska A (2021) Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. PLoS Biol 19:3001302.Caenorhabditis elegans
Jedlicka 2021 Physiol Res2021Jedlička J, Kunc R, Kuncová J (2021) Mitochondrial respiration of human platelets in young adult and advanced age - Seahorse or O2k? Physiol Res 70:369-79.HumanPlatelet
Gerna 2021 Int J Mol Sci2021Gerna D, Arc E, Holzknecht M, Roach T, Jansen-Duerr P, Weiss AKH, Kranner I (2021) AtFAHD1a: a new player influencing seed longevity and dormancy in arabidopsis? Int J Mol Sci 22:2997.Plants
Elliehausen 2021 Exp Gerontol2021Elliehausen CJ, Minton DM, Nichol AD, Konopka AR (2021) Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin. https://doi.org/10.1016/j.exger.2021.111579Guinea pigSkeletal muscle
Dorigatti 2021 Geroscience2021Dorigatti JD, Thyne KM, Ginsburg BC, Salmon AB (2021) Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice. Geroscience 43:1497-511.MouseSkeletal muscle
Schneider 2020 PLoS One2020Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710.RatHeart
Esselun 2020 Neuromolecular Med2020Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 23:140-60.MouseNervous system
Musi 2020 Aging Cell2020Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2020) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.MouseNervous system
Gnad 2020 Cell Metab2020Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, HochhĂ€user A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, BlĂŒher M, Franco R, Bloch W, Virtanen KA, Pfeifer A (2020) Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity. Cell Metab 32:56-70.e7.MouseSkeletal muscle
Gerisch 2020 Dev Cell2020Gerisch B, Tharyan RG, Mak J, Denzel SI, Popkes-van Oepen T, Henn N, Antebi A (2020) HLH-30/TFEB is a master regulator of reproductive quiescence. Dev Cell 53:316-29.Caenorhabditis elegans
Olsen 2020 J Physiol2020Olsen LN, Hoier B, Hansen CV, Leinum M, Carter HH, Jorgensen TS, Bangsbo J, Hellsten Y (2020) Angiogenic potential is reduced in skeletal muscle of aged women. J Physiol 598:5149-64.HumanEndothelial;epithelial;mesothelial cell
Macedo 2020 FASEB J2020Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J 34:9972-81.Caenorhabditis elegans
Ulgherait 2020 Nat Commun2020Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927.Drosophila
No 2020 Pflugers Arch2020No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93.RatHeart
Chamoli 2020 Nat Commun2020Chamoli M, Goyala A, Tabrez SS, Siddiqui AA, Singh A, Antebi A, Lithgow GJ, Watts JL, Mukhopadhyay A (2020) Polyunsaturated fatty acids and p38-MAPK link metabolic reprogramming to cytoprotective gene expression during dietary restriction. Nat Commun 11:4865.Nematodes
Le 2020 J Biol Chem2020Le CH, Benage LG, Specht KS, Li Puma LC, Mulligan CM, Heuberger AL, Prenni JE, Claypool SM, Chatfield KC, Sparagna GC, Chicco AJ (2020) Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria. J Biol Chem 295:12485-97.HumanHeart
Reutzel 2020 Oxid Med Cell Longev2020Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.MouseNervous system
Grewal 2020 Exp Neurol2020Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.HumanNeuroblastoma
Bose 2020 Aging Cell2020Bose C, Alves I, Singh P, Palade PT, Carvalho E, BĂžrsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19:e13261.MouseHeart
Pharaoh 2020 Sci Rep2020Pharaoh G, Brown JL, Sataranatarajan K, Kneis P, Bian J, Ranjit R, Hadad N, Georgescu C, Rabinovitch P, Ran Q, Wren JD, Freeman W, Kinter M, Richardson A, Van Remmen H (2020) Targeting cPLA2 derived lipid hydroperoxides as a potential intervention for sarcopenia. Sci Rep 10:13968.MouseSkeletal muscle
Buch 2020 FASEB J2020Buch BT, Halling JF, Ringholm S, Gudiksen A, KjĂžbsted R, Olsen MA, Wojtaszewski JFP, Pilegaard H (2020) Colchicine treatment impairs skeletal muscle mitochondrial function and insulin sensitivity in an age-specific manner. FASEB J 34:8653-70.MouseSkeletal muscle
Dawson 2020 Exp Gerontol2020Dawson NJ, SalmĂłn P (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Exp Gerontol 133:110883.BirdsBlood cells
Rodriguez 2020 J Gerontol A Biol Sci Med Sci2020RodrĂ­guez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci 76:796-804.Molluscs
Bhaskaran 2020 Aging Cell2020Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225.MouseSkeletal muscle
Serna 2020 J Bioenerg Biomembr2020Serna JDC, Caldeira da Silva CC, Kowaltowski AJ (2020) Functional changes induced by caloric restriction in cardiac and skeletal muscle mitochondria. J Bioenerg Biomembr 52:269-77.RatHeart
Skeletal muscle
Chroeis 2019 Eur J Sport Sci2019ChrĂžis KM, Dohlmann TL, SĂžgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci 20:135-45.HumanSkeletal muscle
Dilberger 2019 Oxid Med Cell Longev2019Dilberger B, Baumanns S, Schmitt F, Schmiedl T, Hardt M, Wenzel U, Eckert GP (2019) Mitochondrial oxidative stress impairs energy metabolism and reduces stress resistance and longevity of C. elegans. Oxid Med Cell Longev 2019:6840540.Caenorhabditis elegans
Pichaud 2019 Front Genet2019Pichaud N, Bérubé R, CÎté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU (2019) Age dependent dysfunction of mitochondrial and ROS metabolism induced by mitonuclear mismatch. Front Genet 10:130.DrosophilaSkeletal muscle
Gururaja Rao 2019 Cells2019Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BKCa (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945.Drosophila
Braganza 2019 JCI Insight2019Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248.HumanSkeletal muscle
Blood cells
Platelet
Tyrrell 2019 Circ Res2019Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314.MouseEndothelial;epithelial;mesothelial cell
Thomas 2019 Redox Biol2019Thomas NO, Shay KP, Hagen TM (2019) Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biol 22:101155.RatLiver
Dilberger 2019 Nutrients2019Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria. Nutrients 11:E1886.Caenorhabditis elegans
Lefranc 2019 Hypertension2019Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68.MouseFat
Paradis 2019 Antioxidants (Basel)2019Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168.MouseSkeletal muscle
Sonjak 2019 J Gerontol A Biol Sci Med Sci2019Sonjak V, Jacob KJ, Spendiff S, Vuda M, Perez A, Miguez K, Minozzo FC, Spake C, Morais JA, Hepple RT (2019) Reduced mitochondrial content, elevated ROS, and modulation by denervation in skeletal muscle of pre-frail/frail elderly women. J Gerontol A Biol Sci Med Sci 74:1887-95.HumanSkeletal muscle
Lee 2019 Nat Metab2019Lee HJ, Noormohammadi A, Koyuncu S, Calculli G, Simic MS, Herholz M, Trifunovic A, Vilchez D (2019) Prostaglandin signals from adult germ stem cells delay somatic aging of Caenorhabditis elegans. Nat Metab 1:790-810.Caenorhabditis elegans
D'Amico 2019 Mol Cell2019D'Amico D, Mottis A, Potenza F, Sorrentino V, Li H, Romani M, Lemos V, Schoonjans K, Zamboni N, Knott G, Schneider BL, Auwerx J (2019) The RNA-binding protein PUM2 impairs mitochondrial dynamics and mitophagy during aging. Mol Cell 73:775-87.MouseSkeletal muscle
Halling 2019 Am J Physiol Endocrinol Metab2019Halling JF, Jessen H, NÞhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525.MouseSkeletal muscle
Fernando 2019 Exp Gerontol2019Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52.MouseSkeletal muscle
Pharaoh 2019 Mol Neurobiol2019Pharaoh G, Owen D, Yeganeh A, Premkumar P, Farley J, Bhaskaran S, Ashpole N, Kinter M, Van Remmen H, Logan S (2019) Disparate central and peripheral effects of circulating IGF-1 deficiency on tissue mitochondrial function. Mol Neurobiol 57:1317-31.MouseSkeletal muscle
Nervous system
Fat
Zhu 2019 Aging Cell2019Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet. Aging Cell 18:e12883.MouseLiver
Munro 2019b Aging Cell2019Munro D, Pamenter ME (2019) Comparative studies of mitochondrial reactive oxygen species in animal longevity: Technical pitfalls and possibilities. Aging Cell 18:e13009.
Crescenzo 2019 Mol Neurobiol2019Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol 56:7651-63.RatNervous system
Bektas 2019 Aging (Albany NY)2019Bektas A, Schurman SH, Gonzalez-Freire M, Dunn CA, Singh AK, Macian F, Cuervo AM, Sen R, Ferrucci L (2019) Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy. Aging (Albany NY) 11:9234-63. https://doi.org/10.18632/aging.102438HumanBlood cells
Lymphocyte
Fang 2019 Nat Commun2019Fang EF, Hou Y, Lautrup S, Jensen MB, Yang B, SenGupta T, Caponio D, Khezri R, Demarest TG, Aman Y, Figueroa D, Morevati M, Lee HJ, Kato H, Kassahun H, Lee JH, Filippelli D, Okur MN, Mangerich A, Croteau DL, Maezawa Y, Lyssiotis CA, Tao J, Yokote K, Rusten TE, Mattson MP, Jasper H, Nilsen H, Bohr VA (2019) NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome. Nat Commun 10:5284.MouseHeart
Nervous system
Liver
Munro 2019 Aging Cell2019Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916.Mouse
Other mammals
Heart
Skeletal muscle
Herholz 2019 Nat Commun2019Herholz M, Cepeda E, Baumann L, Kukat A, Hermeling J, Maciej S, Szczepanowska K, Pavlenko V, Frommolt P, Trifunovic A (2019) KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants. Nat Commun 10:3323.Caenorhabditis elegans
Rampello 2018 Microb Cell2018Rampello NG, Stenger M, Westermann B, Osiewacz HD (2018) Impact of F1Fo-ATP-synthase dimer assembly factors on mitochondrial function and organismic aging. Microb Cell 5:198–207.Fungi
Laouafa 2018 Adv Exp Med Biol2018Laouafa S, Roussel D, Marcouiller F, Soliz J, Bairam A, Joseph V (2018) Role of estradiol receptor beta (ERÎČ) on arterial pressure, respiratory chemoreflex and mitochondrial function in young and aged female mice. Adv Exp Med Biol 1071:115-27.MouseNervous system
Jang 2018 Shock2018Jang DH, Orloski CJ, Owiredu S, Shofer FS, Greenwood JC, Eckmann DM (2018) Alterations in mitochondrial function in blood cells obtained from patients with sepsis presenting to an emergency department. Shock 51:580-84.HumanBlood cells
Vatner 2018 Aging Cell2018Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF (2018) Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell 17:e12751.MouseFat
Ederer 2018 Int J Mol Sci2018Ederer KA, Jin K, Bouslog S, Wang L, Gorman GS, Rowe GC, Abadir P, Raftery D, Moellering D, Promislow D, Jumbo-Lucioni P, De Luca M (2018) Age- and genotype-specific effects of the angiotensin-converting enzyme inhibitor lisinopril on mitochondrial and metabolic parameters in Drosophila melanogaster. Int J Mol Sci 19:3351.Drosophila
Holloway 2018 Cell Rep2018Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018) Age-associated impairments in mitochondrial ADP sensitivity contribute to redox stress in senescent human skeletal muscle. Cell Rep 22:2837–48.HumanSkeletal muscle
Takahashi 2018 Sci Rep2018Takahashi K, Miura Y, Ohsawa I, Shirasawa T, Takahashi M (2018) In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization. Sci Rep 8:15585.MouseNervous system
Vinel 2018 Nat Med2018Vinel C, Lukjanenko L, Batut A, Deleruyelle S, Pradere JP, Le Gonidec S, Dortignac A, Geoffre N, Pereira O, Karaz S, Lee U, Camus M, Chaoui K, Mouisel E, Bigot A, Mouly V, Vigneau M, Pagano AF, Chopard A, Pillard F, Guyonnet S, Cesari M, Burlet-Schiltz O, Pahor M, Feige JN, Vellas B, Valet P, Dray C (2018) The exerkine apelin reverses age-associated sarcopenia. Nat Med 24:1360-71.MouseSkeletal muscle
Gonzalez-Freire 2018 Aging Cell2018Gonzalez-Freire M, Scalzo P, D'Agostino J, Moore ZA, Diaz-Ruiz A, Fabbri E, Zane A, Chen B, Becker KG, Lehrmann E, Zukley L, Chia CW, Tanaka T, Coen PM, Bernier M, de Cabo R, Ferrucci L (2018) Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: the Baltimore longitudinal study of aging. Aging Cell 17.HumanSkeletal muscle
Temelie 2018 Oxid Med Cell Longev2018Temelie M, Savu DI, Moisoi N (2018) Intracellular and intercellular signalling mechanisms following DNA damage are modulated by PINK1. Oxid Med Cell Longev 1391387.Human
Mouse
Nervous system
Other cell lines
Fibroblast
Zhuang 2018 Thesis2018Zhuang Y (2018) Potential application of alternative oxidase (AOX) in neurodegenerative diseases. Master's Thesis p71.MouseNervous system
Champigny 2018 Mar Drugs2018Champigny CM, Cormier RPJ, Simard CJ, St-Coeur PD, Fortin S, Pichaud N (2018) Omega-3 monoacylglyceride effects on longevity, mitochondrial metabolism and oxidative stress: insights from Drosophila melanogaster. Mar Drugs 16:E453.Drosophila
Silva 2018 Nat Cell Biol2018Silva J, Aivio S, Knobel PA, Bailey LJ, Casali A, Vinaixa M, Garcia-Cao I, Coyaud É, Jourdain AA, PĂ©rez-Ferreros P, Rojas AM, Antolin-Fontes A, Samino-GenĂ© S, Raught B, GonzĂĄlez-Reyes A, Ribas de Pouplana L, Doherty AJ, Yanes O, Stracker TH (2018) EXD2 governs germ stem cell homeostasis and lifespan by promoting mitoribosome integrity and translation. Nat Cell Biol 20:162-74.Islet cell;pancreas;thymus
Nacarelli 2018 Geroscience2018Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C (2018) Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. Geroscience 40:243-56.HumanHeart
Fibroblast
Docherty 2018 Atherosclerosis2018Docherty CK, Carswell A, Friel E, Mercer JR (2018) Impaired mitochondrial respiration in human carotid plaque atherosclerosis: A potential role for Pink1 in vascular smooth muscle cell energetics. Atherosclerosis 268:1-11.HumanEndothelial;epithelial;mesothelial cell
Carter 2018 J Physiol2018Carter HN, Kim Y, Erlich AT, Zarrin-Khat D, Hood DA (2018) Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. J Physiol 596:3567-84.RatSkeletal muscle
Zhang 2018 J Gerontol A Biol Sci Med Sci2018Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM (2018) Impaired mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice. J Gerontol A Biol Sci Med Sci 73:1313-22.MouseSkeletal muscle
Mahapatra 2018 Clin Sci (Lond)2018Mahapatra G, Smith SC, Hughes TM, Wagner B, Maldjian JA, Freedman BI, Molina AJA (2018) Blood-based bioenergetic profiling is related to differences in brain morphology in African Americans with Type 2 diabetes. Clin Sci (Lond) 132:2509-18. https://doi.org/10.1042/CS20180690HumanNervous system
Blood cells
Konopka 2018 Aging Cell2018Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF (2018) Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell 18:e12880.HumanSkeletal muscle
Smenes 2018 Interact Cardiovasc Thorac Surg2018Smenes BT, BÊkkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, HÞydal M, WislÞff U, Rognmo Ø, Wahba A (2018) Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg 27:95-101.HumanHeart
Musi 2018 Aging Cell2018Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2018) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.MouseNervous system
Ahn 2018 Redox Biol2018Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H (2018) Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol 17:47-58.MouseSkeletal muscle
Campbell 2018 Free Radic Biol Med2018Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, Qian WJ, Marcinek DJ (2018) Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic Biol Med 134:268-81.MouseSkeletal muscle
Mancini 2017 Thesis2018Mancini G (2017) Colesterol dietético e doença de Alzheimer em modelos experimentais: avaliação da resposta sinåptica, mitocondrial e comportamental. Doctoral Thesis p118.MouseNervous system
Carter 2018 J Appl Physiol (1985)2018Carter HN, Pauly M, Tryon LD, Hood DA (2018) Effect of contractile activity on PGC-1α transcription in young and aged skeletal muscle. J Appl Physiol (1985) 124:1605-15.RatSkeletal muscle
Distefano 2018 J Cachexia Sarcopenia Muscle2018Distefano G, Standley RA, Zhang X, Carnero EA, Yi F, Cornnell HH, Coen PM (2018) Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle 9:279-94.HumanSkeletal muscle
Kauppila 2018 Nucleic Acids Res2018Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69.Mouse
Reutzel 2018 Oxid Med Cell Longev2018Reutzel M, Grewal R, Silaidos C, Zotzel J, Marx S, Tretzel J, Eckert GP (2018) Effects of long-term treatment with a blend of highly purified olive secoiridoids on cognition and brain ATP levels in aged NMRI mice. Oxid Med Cell Longev 2018:4070935.MouseNervous system
MitoFit Open Seminar 2017-07-142017-07-14
MitoFit
Innsbruck AT, 2017 Jul 14. MitoFit Open Seminar on immune cell bioenergetics.
Investigating the role of mitochondria in healthy and psychopathological aging.
HumanBlood cells
Derungs 2017 Mol Psychiatry2017Derungs R, Camici GG, Spescha RD, Welt T, Tackenberg C, SpÀni C, Wirth F, Grimm A, Eckert A, Nitsch RM, Kulic L (2017) Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease. Mol Psychiatry 22:605-14.MouseNervous system
Knuppertz 2017 Aging Cell2017Knuppertz L, Osiewacz HD (2017) Autophagy compensates impaired energy metabolism in CLPXP-deficient Podospora anserina strains and extends healthspan. Aging Cell 16:704-15.Fungi
Gusdon 2017 Exp Gerontol2017Gusdon AM, Callio J, Distefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT (2017) Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Exp Gerontol 90:1-13.MouseNervous system
Fourcade 2017 Aging Cell2017Fourcade S, Morató L, Parameswaran J, Ruiz M, Ruiz-Cortés T, Jové M, Naudí A, Martínez-Redondo P, Dierssen M, Ferrer I, Villarroya F, Pamplona R, Vaquero A, Portero-Otín M, Pujol A (2017) Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance. Aging Cell 16:1404-13.Mouse
Layne 2017 Contemp Clin Trials2017Layne AS, Krehbiel LM, Mankowski RT, Anton SD, Leeuwenburgh C, Pahor M, Sandesara B, Wu SS, Buford TW (2017) Resveratrol and exercise to treat functional limitations in late life: Design of a randomized controlled trial. Contemp Clin Trials 6:58–63.HumanSkeletal muscle
Asseburg 2017 Thesis2017Asseburg H (2017) Untersuchungen zur nutritiven PrĂ€vention der Neurodegeneration – Wirkungen von Trauben- und Olivenpolyphenolen auf die mitochondriale und kognitive Dysfunktion bei der Gehirnalterung und Alzheimer-Erkrankung. Dissertation p296.Mouse
Rat
Nervous system
Other cell lines
Khalifa 2017 Physiol Rep2017Khalifa AR, Abdel-Rahman EA, Mahmoud AM, Ali MH, Noureldin M, Saber SH, Mohsen M, Ali SS (2017) Sex-specific differences in mitochondria biogenesis, morphology, respiratory function, and ROS homeostasis in young mouse heart and brain. Physiol Rep 5. pii: e13125.MouseHeart
Nervous system
Buso 2017 Thesis2017Buso A (2017) Mitochondrial oxidative phosphorylation plasticity/adaptation triggered by disturbances and stresses and targeted by therapies. PhD Thesis p110.MouseSkeletal muscle
Uzhachenko 2017 Aging (Albany NY)2017Uzhachenko R, Boyd K, Olivares-Villagomez D, Zhu Y, Goodwin JS, Rana T, Shanker A, Tan WJ, Bondar T, Medzhitov R, Ivanova AV (2017) Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging (Albany NY) 9:627-49.MouseKidney
Endothelial;epithelial;mesothelial cell
Fibroblast
Thomas 2017 Thesis2017Thomas NO (2017) Age-related decrease in resilience against acute redox cycling agents: critical role of declining GSH-dependent detoxification capacity. Dissertation p141.RatLiver
Lalia 2017 Aging (Albany NY)2017Lalia AZ, Dasari S, Robinson MM, Abid H, Morse DM, Klaus KA, Lanza IR (2017) Influence of omega-3 fatty acids on skeletal muscle protein metabolism and mitochondrial bioenergetics in older adults. Aging (Albany NY) 9:1096-1129.HumanSkeletal muscle
Robinson 2017 Cell Metabol2017Robinson MM, Dasari S, Konopka AR, Johnson ML, Manjunatha S, Esponda RR, Carter RE, Lanza IR, Nair KS (2017) Enhanced protein translation underlies improved metabolic and physical adaptations to different exercise training modes in young and old humans. Cell Metab 25:581-92.HumanSkeletal muscle
Anderson 2017 Cell Metab2017Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD (2017) SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion. Cell Metab 25:838-55.MouseHeart
Liver
Tepp 2017 Mol Cell Biochem2017Tepp K, Puurand M, Timohhina N, Adamson J, Klepinin A, Truu L, Shevchuk I, Chekulayev V, Kaambre T (2017) Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging. Mol Cell Biochem 432:141-58.RatHeart
Takahashi 2017 Exp Gerontol2017Takahashi K, Ohsawa I, Shirasawa T, Takahashi M (2017) Optic atrophy 1 mediates coenzyme Q-responsive regulation of respiratory complex IV activity in brain mitochondria. Exp Gerontol 98:217-223.MouseNervous system
Lang 2017 Aging (Albany NY)2017Lang A, Anand R, Altinoluk-HambĂŒchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, HĂ€nsel J, Franke M, StĂŒhler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP (2017) SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging (Albany NY) 9:2163-89.HumanKidney
HEK
Chabi 2016 Exp Gerontol2016Chabi B, Pauly M, Carillon J, Carnac G, Favier FB, Fouret G, Bonafos B, Vanterpool F, Vernus B, Coudray C, Feillet-Coudray C, Bonnieu Z, Lacan D, Koechlin-Ramonatxo C (2016) Protective effect of myostatin gene deletion on aging-related muscle metabolic decline. Exp Gerontol 78:23-31.MouseSkeletal muscle
Berschneider 2016 Thesis2016Berschneider K (2016) Connecting the functions of the proteasome and mitochondria in the lung. Dissertation p161.MouseLung;gill
Volt 2016 J Pineal Res2016Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D (2016) Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J Pineal Res 60:193-205.MouseHeart
Camacho-Pereira 2016 Cell Metab2016Camacho-Pereira J, TarragĂł MG, Chini CC, Nin V, Escande C, Warner GM, Puranik AS, Schoon RA, Reid JM, Galina A, Chini EN (2016) CD38 dictates age-related NAD decline and mitochondrial dysfunction through an SIRT3-dependent mechanism. Cell Metab 23:1127-39.Human
Mouse
Liver
Lung;gill
Other cell lines
Takahashi 2016 Exp Gerontol2016Takahashi K, Ohsawa I, Shirasawa T, Takahashi M (2016) Early-onset motor impairment and increased accumulation of phosphorylated α-synuclein in the motor cortex of normal aging mice are ameliorated by coenzyme Q. Exp Gerontol 81:65-75.MouseNervous system
Svenkrtova 2016 Biogerontology2016Svenkrtova A, Belicova L, Volejnikova A, Sigler K, Jazwinski SM, Pichova A (2016) Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality. Biogerontology 17:395-408.Saccharomyces cerevisiae
Spendiff 2016 J Physiol2016Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan NJ, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RT (2016) Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J Physiol 594:7361-79.Human
Mouse
Skeletal muscle
Lalia 2016 J Clin Endocrinol Metab2016Lalia AZ, Dasari S, Johnson ML, Robinson MM, Konopka AR, Distelmaier K, Port JD, Glavin MT, Esponda RR, Nair KS, Lanza IR (2016) Predictors of whole-body insulin sensitivity across ages and adiposity in adult humans. J Clin Endocrinol Metab 101:626-34.HumanSkeletal muscle
Gregg 2016 Diabetes2016Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ (2016) Pancreatic ÎČ cells from mice offset age-associated mitochondrial deficiency with reduced KATP channel activity. Diabetes 65:2700-10.Human
Mouse
Islet cell;pancreas;thymus
Other cell lines
Reis 2016 Aging (Albany NY)2016Reis FC, Branquinho JL, BrandĂŁo BB, Guerra BA, Silva ID, Frontini A, Thomou T, Sartini L, Cinti S, Kahn CR, Festuccia WT, Kowaltowski AJ, Mori MA (2016) Fat-specific Dicer deficiency accelerates aging and mitigates several effects of dietary restriction in mice. Aging (Albany NY) 8:1201-22.MouseFat
Asseburg 2016 Neuromolecular Med2016Asseburg H, SchĂ€fer C, MĂŒller M, Hagl S, Pohland M, Berressem D, Borchiellini M, Plank C, Eckert GP (2016) Effects of grape skin extract on age-related mitochondrial dysfunction, memory and life span in C57BL/6J mice. Neuromolecular Med 18:378-95.MouseNervous system
Li 2016 J Appl Physiol (1985)2016Li C, White SH, Warren LK, Wohlgemuth SE (2016) Effects of aging on mitochondrial function in skeletal muscle of quarter horses. J Appl Physiol (1985) 121:299-311.HorseSkeletal muscle
Wolff 2016 J Evol Biol2016Wolff JN, Pichaud N, Camus MF, CÎté G, Blier PU, Dowling DK (2016) Evolutionary implications of mitochondrial genetic variation: mitochondrial genetic effects on OXPHOS respiration and mitochondrial quantity change with age and sex in fruit flies. J Evol Biol 29:736-47.DrosophilaSkeletal muscle
Eisenberg 2016 Nat Med2016Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, BĂŒttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, MĂŒhlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F (2016) Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med 22:1428-38.MouseHeart
Kontro 2016 Thesis2016Kontro H (2016) Mitochondrial function and sirtuin expression in hippocampus of young and old high and low-capacity runner rats. Master's Thesis p35.RatNervous system
Valenzuela 2016 Cell Death Dis2016Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, Perez-Costas E, Villar-Cheda B, Garrido-Gil P, Melendez-Ferro M, Soto-Otero R, Lanciego JL, Henrion D, Franco R, Labandeira-Garcia JL (2016) Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death Dis 7:e2427.Mouse
Rat
Nervous system
Scialo 2016 Cell Metab2016ScialĂČ F, Sriram A, FernĂĄndez-Ayala D, Gubina N, LĂ”hmus M, Nelson G, Logan A, Cooper HM, Navas P, EnrĂ­quez JA, Murphy MP, Sanz A (2016) Mitochondrial ROS produced via reverse electron transport extend animal lifespan. Cell Metab 23:725-34.Drosophila
Lores-Arnaiz 2016 Neurochem Res2016Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63.MouseNervous system
Dias 2016 Neurobiol Aging2016Dias C, Lourenço CF, Ferreiro E, Barbosa RM, Laranjinha J, Ledo A (2016) Age-dependent changes in the glutamate-nitric oxide pathway in the hippocampus of the triple transgenic model of Alzheimer's disease: implications for neurometabolic regulation. Neurobiol Aging 46:84-95.MouseNervous system
Zelenka 2016 Oxid Med Cell Longev2016Zelenka J, Dvoƙák A, Alán L, Zadinová M, Haluzík M, Vítek L (2016) Hyperbilirubinemia protects against aging-associated inflammation and metabolic deterioration. Oxid Med Cell Longev ID 6190609:10p.RatLiver
Kidney
Fibroblast
Mills 2016 Cell Metab2016Mills KF, Yoshida S, Stein LR, Uchida K, Yoshino J, Imai SI (2016) Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab 24:1–12.MouseSkeletal muscle
Docherty 2016 Stem Cell Res Ther2016Docherty CK, Salt IP, Mercer JR (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Res Ther 7:78.HumanKidney
HEK
Distefano 2016 J Gerontol A Biol Sci Med Sci2016Distefano G, Standley RA, Dubé JJ, Carnero EA, Ritov VB, Stefanovic-Racic M, Toledo FG, Piva SR, Goodpaster BH, Coen PM (2016) Chronological age does not influence ex-vivo mitochondrial respiration and quality control in skeletal muscle. J Gerontol A Biol Sci Med Sci 72:535-42.HumanSkeletal muscle
Reijne 2016 PLOS ONE2016Reijne AC, Ciapaite J, van Dijk TH, Havinga R, van der Zee EA, Groen AK, Reijngoud DJ, Bakker BM, van Dijk G (2016) Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice. PLOS ONE 11:e0149419.MouseSkeletal muscle
Liver
Hagl 2016 Neuromolecular Med2016Hagl S, Asseburg H, Heinrich M, Sus N, Blumrich EM, Dringen R, Frank J, Eckert GP (2016) Effects of long-term rice bran extract supplementation on survival, cognition and brain mitochondrial function in aged NMRI mice. Neuromolecular Med 18:347-63.MouseNervous system
Pokkunuri 2016 Oxid Med Cell Longev2016Pokkunuri I, Ali Q, Asghar M (2016) Grape powder improves age-related decline in mitochondrial and kidney functions in Fischer 344 rats. Oxid Med Cell Longev ID 6135319:8p.RatKidney
Moll 2016 bioRxiv2016Moll CWI, Lindtner RA, Vogel GF, Brunner M, Gutleben K, Blauth M, Krumschnabel G, Ebner HL (2016) Bone marrow mesenchymal stem cells from osteoporotic patients do not show altered mitochondrial energetics or ultrastructure. bioRxiv doi.org/10.1101/046300.HumanStem cells
Hagl 2016 Nutr Neurosci2016Hagl S, Berressem D, Grewal R, Grebenstein N, Frank J, Eckert GP (2016) Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. Nutr Neurosci 19:1-10.MouseNervous system
Yavari 2016 Cell Metab2016Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Martinez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, Toth M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H (2016) Chronic activation of Îł2 AMPK induces obesity and reduces ÎČ cell function. Cell Metab 23:821-36.MouseNervous system
Wang 2015 Nat Commun2015Wang Y, Oxer D, Hekimi S (2015) Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis. Nat Commun 6:6393.MouseHeart
Skeletal muscle
Kidney
Kruse 2015 Aging Cell2015Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ (2015) Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell 15:89-99.MouseSkeletal muscle
Richman 2015 PLoS Genet2015Richman TR, Ermer JA, Davies SM, Perks KL, Viola HM, Shearwood AM, Hool LC, Rackham O, Filipovska A (2015) Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction. PLoS Genet 11:e1005089.MouseHeart
Liver
Gram 2015 J Physiol2015Gram M, VigelsĂž A, Yokota T, Helge JW, Dela F, Hey-Mogensen M (2015) Skeletal muscle mitochondrial H2O2 emission increases with immobilization and decreases after aerobic training in young and older men. J Physiol 593:4011-27.HumanSkeletal muscle
Lourenco 2015 Front Aging Neurosci2015Lourenço CF, Ledo A, Dias C, Barbosa RM, Laranjinha J (2015) Neurovascular and neurometabolic derailment in aging and Alzheimer's disease. Front Aging Neurosci 7:103.MouseNervous system
Bernhardt 2015 Sci Rep2015Bernhardt D, MĂŒller M, Reichert AS, Osiewacz HD (2015) Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan. Sci Rep 5:7885.Saccharomyces cerevisiae
Hey-Mogensen 2015 J Physiol2015Hey-Mogensen M, Gram M, Jensen MB, Lund MT, Hansen CN, Scheibye-Knudsen M, Bohr VA, Dela F (2015) A novel method for determining human ex vivo submaximal skeletal muscle mitochondrial function. J Physiol 593:3991-4010.HumanSkeletal muscle
Johnson 2015 Aging Cell2015Johnson ML, Lalia AZ, Dasari S, Pallauf M, Fitch M, Hellerstein MK, Lanza IR (2015) Eicosapentaenoic acid but not docosahexaenoic acid restores skeletal muscle mitochondrial oxidative capacity in old mice. Aging Cell 14:734-43.MouseSkeletal muscle
Grimm 2015 Exp Gerontol2015Grimm C, Osiewacz HD (2015) Manganese rescues adverse effects on lifespan and development in Podospora anserina challenged by excess hydrogen peroxide. Exp Gerontol 63:8-17.Fungi
Paeaesuke 2015 Oxid Med Cell Longev2015PÀÀsuke R, Eimre M, Piirsoo A, Peet N, Laada L, Kadaja L, Roosimaa M, PÀÀsuke M, MÀrtson A, Seppet E, Paju K (2015) Proliferation of human primary myoblasts is associated with altered energy metabolism in dependence of ageing in vivo and in vitro. Oxid Med Cell Longev 8296150:10p.HumanSkeletal muscle
Zelenka 2015 Oxid Med Cell Longev2015Zelenka J, Dvoƙák A, Alán L (2015) L-lactate protects skin fibroblasts against aging-associated mitochondrial dysfunction via mitohormesis. Oxid Med Cell Longev 2015:351698.RatLiver
Endothelial;epithelial;mesothelial cell
Fibroblast
Hendricks 2015 Thesis2015Hendricks EW (2015) The impact of aging and estrogen therapy on synaptic mitochondrial bioenergetics in an Alzheimer's mouse model. Master Thesis 1-67.MouseNervous system
Porter 2015 Am J Physiol Endocrinol Metab2015Porter C, Hurren NM, Cotter MV, Bhattarai N, Reidy PT, Dillon EL, Durham WJ, Tuvdendorj D, Sheffield-Moore M, Volpi E, Sidossis LS, Rasmussen BB, BĂžrsheim E (2015) Mitochondrial respiratory capacity and coupling control decline with age in human skeletal muscle. Am J Physiol Endocrinol Metab 309:E224-32.HumanSkeletal muscle
Gram 2014 Exp Gerontol2014Gram M, Vigelsoe A, Yokota T, Hansen CN, Helge JW, Hey-Mogensen M, Dela F (2014) Two weeks of one-leg immobilization decreases skeletal muscle 2 respiratory capacity equally in young and elderly men. Exp Gerontol 58C:269-78.HumanSkeletal muscle
Gouspillou 2014 FASEB J2014Gouspillou G, Sgarioto N, Kapchinsky S, Purves-Smith F, Norris B, Pion CH, Barbat-Artigas S, Lemieux F, Taivassalo T, Morais JA, Aubertin-Leheudre M, Hepple RT (2014) Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans. FASEB J 28:1621-33.HumanSkeletal muscle
Bleier 2014 Free Radic Biol Med2014Bleier L, Wittig I, Heide H, Steger M, Brandt U, Droese S4 (2014) Generator-specific targets of mitochondrial reactive oxygen species. Free Radic Biol Med 78:1-10.RatHeart
Castelein 2014 Exp Gerontol2014Castelein N, Muschol M, Dhondt I, Cai H, De Vos WH, Dencher NA, Braeckman BP (2014) Mitochondrial efficiency is increased in axenically cultured Caenorhabditis elegans. Exp Gerontol 56:26-36.Caenorhabditis elegans
Afshordel 2014 Prostaglandins Leukot Essent Fatty Acids2014Afshordel S, Hagl S, Werner D, Roehner N, Koegel D, Bazan NG, Eckert GP (2014) Omega-3 polyunsaturated fatty acids improve mitochondrial dysfunction in brain aging - impact of Bcl-2 and NPD-1 like metabolites. Prostaglandins Leukot Essent Fatty Acids 92:23-31.MouseNervous system
Takahashi 2014 Exp Gerontol2014Takahashi K, Noda Y, Ohsawa I, Shirasawa T, Takahashi M (2014) Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice. Exp Gerontol 58:146-53.MouseSkeletal muscle
Liver
Stier 2013 Front Zool2013Stier A, Bize P, Schull Q, Zoll J, Singh F, Geny B, Gros F, Royer C, Massemin S, Criscuolo F (2013) Avian erythrocytes have functional mitochondria, opening novel perspectives for birds as animal models in the study of ageing. Front Zool 10:33.Mouse
Birds
Blood cells
Johnson 2013 Trends Endocrinol Metab2013Johnson ML, Robinson MM, Nair KS (2013) Skeletal muscle aging and the mitochondrion. Trends Endocrinol Metab 24:247-56.HumanSkeletal muscle
Volejnikova 2013 FEMS Yeast Res2013VolejnĂ­kovĂĄ A, HlouskovĂĄ J, Sigler K, PichovĂĄ A (2013) Vital mitochondrial functions show profound changes during yeast culture ageing. FEMS Yeast Res 13:7-15.Saccharomyces cerevisiae
Fungi
Mohan 2013 Thesis University of Technology - Tampere2013Mohan AK (2013) The effect of mitochondrial superoxide on drosophila lifespan. Thesis University of Technology - Tampere 56pp.Hexapods
Coen 2013 J Gerontol A Biol Sci Med Sci2013Coen PM, Jubrias SA, Distefano G, Amati F, Mackey DC, Glynn NW, Manini TM, Wohlgemuth SE, Leeuwenburgh C, Cummings SR, Newman AB, Ferrucci L, Toledo FG, Shankland E, Conley KE, Goodpaster BH (2013) Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults. J Gerontol A Biol Sci Med Sci 68:447-55.HumanSkeletal muscle
Guitart 2013 Nucleic Acids Res2013Guitart T, Picchioni D, Piñeyro D, Ribas de Pouplana L (2013) Human mitochondrial disease-like symptoms caused by a reduced tRNA aminoacylation activity in flies. Nucleic Acids Res 41:6595-608.Drosophila
Hexapods
Kelly 2013 Stem Cells2013Kelly RD, Rodda AE, Dickinson A, Mahmud A, Nefzger CM, Lee W, Forsythe J, Polo JM, Trounce IA, McKenzie M, Nisbet DR, St John JC (2013) Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells. Stem Cells 31:703-16.MouseHeart
Stem cells
Munro 2013 Aging Cell2013Munro D, Pichaud N, Paquin F, Kemeid V, Blier PU (2013) Low hydrogen peroxide production in mitochondria of the long-lived Arctica islandica: underlying mechanisms for slow aging. Aging Cell 12:5845-92.MolluscsEndothelial;epithelial;mesothelial cell
Sjoevall 2013 Mitochondrion2013Sjövall F, Ehinger JK, Marelsson SE, Morota S, Asander Frostner E, Uchino H, Lundgren J, Arnbjörnsson E, Hansson Magnus J, Fellman V, Elmér E (2013) Mitochondrial respiration in human viable platelets - methodology and influence of gender, age and storage. Mitochondrion 13:7-14.HumanBlood cells
Platelet
Jacobs 2013 J Gerontol A Biol Sci Med Sci2013Jacobs R, Diaz V, Soldini L, Haider T, Thomassen M, Nordsborg NB, Gassmann M, Lundby C (2013) Fast-twitch glycolytic skeletal muscle is predisposed to age-induced impairments in mitochondrial function. J Gerontol A Biol Sci Med Sci 68:1010-22.MouseSkeletal muscle
Koziel 2013 Biochem J2013Koziel R, Pircher H, Kratochwil M, Lener B, Hermann M, Dencher NA, Jansen-Duerr P (2013) Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4. Biochem J 452:231-9.HumanEndothelial;epithelial;mesothelial cell
Duicu 2013 Can J Physiol Pharmacol2013Duicu OM, Mirica SN, Gheorgheosu DE, Privistirescu AI, Fira-Mladinescu O, Muntean DM (2013) Ageing-induced decrease in cardiac mitochondrial function in healthy rats. Can J Physiol Pharmacol 91:593-600.RatHeart
Takahashi 2013 Mech Ageing Dev2013Takahashi K, Takahashi M (2013) Exogenous administration of coenzyme Q10 restores mitochondrial 3 oxygen consumption in the aged mouse brain. Mech Ageing Dev 134:580-6.MouseNervous system
Larsen 2012 Acta Physiol (Oxf)2012Larsen S, Hey-Mogensen M, Raboel R, Stride N, Helge JW, Dela F (2012) The influence of age and aerobic fitness: Effects on mitochondrial respiration in skeletal muscle. Acta Physiol (Oxf) 205:423-32.HumanSkeletal muscle
Picard 2012 PLoS One2012Picard M, Wright KJ, Ritchie D, Thomas MM, Hepple RT (2012) Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium. PLoS One 7:e43003.RatHeart
Joergensen 2012 Am J Physiol Endocrinol Metab2012JĂžrgensen W, Jelnes P, Rud KA, Hansen LL, Grunnet N, Quistorff B (2012) Progression of type 2 diabetes in GK rats affects muscle and liver mitochondria differently: pronounced reduction of Complex II flux is observed in liver only. Am J Physiol Endocrinol Metab 303:E515-23.RatSkeletal muscle
Liver
Lanza 2012 Cell Metab2012Lanza IR, Zabielski P, Klaus KA, Morse DM, Heppelmann CJ, Bergen HR 3rd, Dasari S, Walrand S, Short KR, Johnson ML, Robinson MM, Schimke JM, Jakaitis DR, Asmann YW, Sun Z, Nair KS (2012) Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis. Cell Metab 16:777-88.MouseSkeletal muscle
Hempenstall 2012 Mech Ageing Dev2012Hempenstall S, Page MM, Wallen KR, Selman C (2012) Dietary restriction increases skeletal muscle mitochondrial respiration but not mitochondrial content in C57BL/6 mice. Mech Ageing Dev 133:37-45.MouseSkeletal muscle
Albertini 2012 Aging (Albany NY)2012Albertini E, KozieƂ R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Aging (Albany NY) 4:664-73.HumanEndothelial;epithelial;mesothelial cell
HUVEC
Leuner 2012 Mol Neurobiol2012Leuner K, Schulz K, SchĂŒtt T, Pantel J, Prvulovic D, Rhein V, Savaskan E, Czech C, Eckert A, MĂŒller WE (2012) Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes. Mol Neurobiol 46:194-204.HumanBlood cells
Lymphocyte
Stride 2012 Front Physiol2012Stride N, Larsen S, Treebak JT, Hansen CN, Hey-Mogensen M, Speerschneider T, Jensen TE, Jeppesen J, Wojtaszewski JF, Richter EA, KĂžber L, Dela F (2012) 5'-AMP activated protein kinase is involved in the regulation of myocardial ÎČ-oxidative capacity in mice. Front Physiol 3:33.MouseHeart
Boyle 2012 Brain Res2012Boyle JP, Hettiarachchi NT, Wilkinson JA, Pearson HA, Scragg JL, Lendon C, Al-Owais MM, Kim CB, Myers DM, Warburton P, Peers C (2012) Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells. Brain Res 1443:75-88.HumanNeuroblastoma
Horan 2012 J Gerontol A Biol Sci Med Sci2012Horan MP, Pichaud N, Ballard JWO (2012) Review: Quantifying mitochondrial dysfunction in complex diseases of aging. J Gerontol A Biol Sci Med Sci 67:1022-35. https://doi.org/10.1093/gerona/glr263
Rufini 2012 Genes Dev2012Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, Marino A, Federici M, Dinsdale D, Knight RA, Melino G, Mak TW (2012) TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev 26:2009-14.Mouse
Ramirez-Torres 2012 J Proteomics2012Ramirez-Torres A, Barcelo-Batllori S, Fernandez-Vizarra E, Navarro MA, Arnal C, Guillen N, Acin S, Osada J (2012) Proteomics and gene expression analyses of mitochondria from squalene-treated apoE-deficient mice identify short-chain specific acyl-CoA dehydrogenase changes associated with fatty liver amelioration. J Proteomics 75:2563-75.MouseLiver
Correa 2012 Mitochondrion2012Correa CC, Aw WC, Melvin RG, Pichaud N, Ballard JWO (2012) Mitochondrial DNA variants influence mitochondrial bioenergetics in Drosophila melanogaster. Mitochondrion 12:459-64.Drosophila
Hexapods
Skeletal muscle
Joseph 2012 Aging Cell2012Joseph AM, Adhihetty PJ, Buford TW, Wohlgemuth SE, Lees HA, Nguyen LM, Aranda JM, Sandesara BD, Pahor M, Manini TM, Marzetti E, Leeuwenburgh C (2012) The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals. Aging Cell 11:801-9.HumanSkeletal muscle
KozieƂ 2011 J Invest Dermatol2011KozieƂ R, Greussing R, Maier AB, Declercq L, Jansen-DĂŒrr P (2011) Functional interplay between mitochondrial and proteasome activity in skin aging. J Invest Dermatol 131:594-603.HumanFibroblast
Picard 2011 Aging Cell2011Picard M, Ritchie D, Wright KJ, Romestaing C, Thomas MM, Rowan SL, Taivassalo T, Hepple RT (2011) Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers. Aging Cell 9:1032–46.RatSkeletal muscle
Rhein 2010 PloS One2010Rhein V, Giese M, Baysang G, Meier F, Rao S, Schulz KL, Hamburger M, Eckert A (2010) Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure. PloS One 5:e12359.Neuroblastoma
Jones 2010 Biochim Biophys Acta2010Jones TT, Brewer GJ (2010) Age-related deficiencies in Complex I endogenous substrate availability and reserve capacity of Complex IV in cortical neuron electron transport. Biochim Biophys Acta 1797:167-76.RatNervous system
Lim 2010 Proteomics2010Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, Guilhaus M, Ittner LM, Eckert A, Goetz J (2010) Abeta and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 10:1621-33.HumanNervous system
Passos 2010 Mol Syst Biol2010Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T (2010) Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol 6:347.
Dikov 2010 Exp Gerontol2010Dikov D, Aulbach A, Muster B, Dröse S, Jendrach M, Bereiter-Hahn J (2010) Do UCP2 and mild uncoupling improve longevity? Exp Gerontol 45:586-95.HeLa
Fibroblast
HUVEC
Lanza 2010 Curr Opin Clin Nutr Metab Care2010Lanza IR, Nair KS (2010) Mitochondrial metabolic function assessed in vivo and in vitro. Curr Opin Clin Nutr Metab Care 13:511-7.HumanSkeletal muscle
Lemieux 2010 J Gerontol A Biol Sci Med Sci2010Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J Gerontol A Biol Sci Med Sci 65:1157-64.RatHeart
Casas 2009 PloS One2009Casas F, Pessemesse L, Grandemange S, Seyer P, Baris O, Gueguen N, Ramonatxo C, Perrin F, Fouret G, Lepourry L, Cabello G, Wrutniak-Cabello C (2009) Overexpression of the mitochondrial T3 receptor induces skeletal muscle atrophy during aging. PLoS One 4:e5631.MouseSkeletal muscle
Gispert 2009 PLoS One2009Gispert S, Ricciardi F, Kurz A, Azizov M, Hoepken HH, Becker D, Voos W, Leuner K, MĂŒller WE, Kudin AP, Kunz WS, Zimmermann A, Roeper J, Wenzel D, Jendrach M, GarcĂ­a-ArencĂ­bia M, FernĂĄndez-Ruiz J, Huber L, Rohrer H, Barrera M, Reichert AS, RĂŒb U, Chen A, Nussbaum RL, Auburger G (2009) Parkinson phenotype in aged PINK1-deficient mice is accompanied by progressive mitochondrial dysfunction in absence of neurodegeneration. PLoS One 4:e5777.MouseNervous system
Gnaiger 2009 Int J Biochem Cell Biol2009Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. https://doi.org/10.1016/j.biocel.2009.03.013Human
Mouse
Skeletal muscle
Guachalla 2009 Aging (Albany NY)2009Guachalla LM, Ju Z, Koziel R, Figura G, Song Z, Fusser M, Epe B, Jansen-DĂŒrr P, Rudolph KL (2009) SOD2 haploinsufficiency does not accelerate aging of telomere dysfunctional mice. Aging (Albany NY) 1:303-15.MouseNervous system
Osenbroch 2009 FEBS J2009Osenbroch Poe, Auk-Emblem P, Halsne R, Strand J, Forstroem RJ, van der Pluijm I, Eide L (2009) Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells. FEBS J 276:2811-21.Mouse
Hauptmann 2009 Neurobiol Aging2009Hauptmann S, Scherping I, Dröse S, Brandt U, Schulz KL, Jendrach M, Leuner K, Eckert A, MĂŒller WE (2009) Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 30:1574-86.MouseNervous system
Anderson 2009 J Am Coll Cardiol2009Anderson EJ, Kypson AP, Rodriguez E, Anderson CA, Lehr EJ, Neufer PD (2009) Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll Cardiol 54:1891-8.HumanHeart
Hlavata 2008 Aging Cell2008Hlavatå L, Nachin L, Jezek P, Nyström T (2008) Elevated Ras/protein kinase A activity in Saccharomyces cerevisiae reduces proliferation rate and lifespan by two different reactive oxygen species-dependent routes. Aging Cell 7:148-57.Saccharomyces cerevisiae
Fungi
Gillardon 2008 Proteomics Clin Appl2008Gillardon F, Mack M, Rist W, Schnack C, Lenter M, Hildebrandt T, Hengerer B (2008) MicroRNA and proteome expression profiling in early-symptomatic α-synuclein(A30P)-transgenic mice. Proteomics Clin Appl 2:697-705.MouseNervous system
Bustamante 2008 Neurochem Res2008Bustamante J, Czerniczyniec A, Cymeryng C, Lores-Arnaiz S (2008) Age related changes from youth to adulthood in rat brain cortex: nitric oxide synthase and mitochondrial respiratory function. Neurochem Res 33:1216-23.RatNervous system
Nabben 2008 FEBS Lett2008Nabben M, Hoeks J, Briedé JJ, Glatz JF, Moonen-Kornips E, Hesselink MK, Schrauwen P (2008) The effect of UCP3 overexpression on mitochondrial ROS production in skeletal muscle of young versus aged mice. FEBS Lett 582:4147-52.MouseSkeletal muscle
Calvo 2008 FASEB J2008Calvo AC, Pey AL, Ying M, Loer CM, Martinez A (2008) Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans. FASEB J 22:3046-58.Caenorhabditis elegans
Nematodes
Human
De Cavanagh 2008 Exp Gerontol2008de Cavanagh EM, Flores I, Ferder M, Inserra F, Ferder L (2008) Renin-angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content and gene expression. Exp Gerontol 43:919-28.RatLiver
Huetter 2007 Aging Cell2007HĂŒtter E, Skovbro M, Lener B, Prats C, Rabol R, Dela F, Jansen-DĂŒrr P (2007) Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle. Aging Cell 6:245-56.HumanSkeletal muscle
Huetter 2006 Exp Gerontol2006HĂŒtter E, Unterluggauer H, Garedew A, Jansen-DĂŒrr P, Gnaiger E (2006) High-resolution respirometry - a modern tool in aging research. Exp Gerontol 41:103-9.HumanEndothelial;epithelial;mesothelial cell
HUVEC
David 2005 J Biol Chem2005David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Dröse S, Brandt U, Muller WE, Eckert A, Götz J (2005) Proteomic and functional analysis reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem 280:23802-14.MouseNervous system
Huetter 2004 Biochem J2004HĂŒtter E, Renner K, Pfister G, Stöckl P, Jansen-DĂŒrr P, Gnaiger E (2004) Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts. https://doi.org/10.1042/BJ20040095HumanFibroblast
Rosenfeld 2003 Yeast2003Rosenfeld E, Beauvoit B (2003) Role of the non-respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae. Yeast 20:1115-44.Saccharomyces cerevisiae
Fungi
Pich 2002 Free Radic Res2002Pich MM, Castagnoli A, Biondi A, Bernacchia A, Tazzari PL, D'Aurelio M, Castelli GP, Formiggini G, Conte R, Bovina C, Lenaz G (2002) Ubiquinol and a coenzyme Q reducing system protect platelet mitochondrial function of transfusional buffy coats from oxidative stress. Free Radic Res 36:429-36.Blood cells
Platelet
Aguilaniu 2001 J Biol Chem2001Aguilaniu H, Gustafsson L, Rigoulet M, Nyström T (2001) Protein oxidation in G0 cells of Saccharomyces cerevisiae depends on the state rather than rate of respiration and is enhanced in pos9 but not yap1 mutants. J Biol Chem 276:35396-404.Saccharomyces cerevisiae
Fungi
Nystroem 1996 EMBO J1996Nyström T, Larsson C, Gustafsson L (1996) Bacterial defence against ageing: Role of the Escherichia coli ArcA regulator in gene expression, readjusted energy flux and survival during stress. EMBO J 15:3219-28.
O2k-Publications in the MiPMap

O2k-Publications: Aging;senescence - Abstracts

Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceOrganismTissue;cell
Gnaiger 2022 ESCI Bari2022
Erich Gnaiger
Gnaiger E (2022) Bioenergetic cluster analysis – diagnostic evaluation of mitochondrial respiratory control in human fibroblasts. 56th Annual Scientific Meeting of the European Society for Clinical Investigation.
HumanFibroblast
Ebanks 2022 Abstract Bioblast2022P09.
Brad Ebanks
Ebanks Brad, Wang Y, Katyal G, Sargent C, Ingram TL, Bowman A, Moisoi N, Chakrabarti L (2022) Exercise alters mitochondrial physiology and has age-specific impacts on the fitness and lifespan of D. melanogaster. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
Drosophila
Blier 2019 MiP20192019
Pierre Blier
The secrets of extreme longevity from bivalves.
Molluscs
Goikoetxea-Usandizaga 2019 MiPschool Coimbra2019
Naroa Goikoetxea Usandizaga
Methylation Controlled J protein (MCJ): A therapeutic target in hepatic ischemia and reperfusion injury.
MouseLiver
Goncalves Debora 2019 MiPschool Coimbra2019
MiPsociety
Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster.
Drosophila
Kramer 2019 Abstract IOC1412019Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.HumanSkeletal muscle
Chicco 2018 MiP2018a2018
Adam J Chicco
Maternal aging increases granulosa cell mitochondrial ROS release and reduces oocyte OXPHOS-linked respiration: implications for embryo development.
HorseGenital
Hoppel 2018 MiPschool Tromso D12018
Charles Hoppel
Two populations of muscle mitochondria: heart and skeletal muscle.
Rat
Dog
Other mammals
Heart
Skeletal muscle
Calabria 2017 MiP20172017
Elisa Calabria
Age and frailty related changes in PBMCs mitochondrial function and whole body physiology.
HumanBlood cells
MitoFit Open Seminar 2017-07-142017
MitoFit
Innsbruck AT, 2017 Jul 14. MitoFit Open Seminar on immune cell bioenergetics.
Investigating the role of mitochondria in healthy and psychopathological aging.
HumanBlood cells
Calabria 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Age and frailty related changes in PBMCs mitochondrial function and whole body physiology.
HumanBlood cells
Nemec 2017 MiP20172017
Michal Nemec
Three-month exercise modulates skeletal muscle mitochondria function in patients with mild cognitive impairment.
HumanSkeletal muscle
Nemec 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Functional state of mitochondria in patients with preclinical cognitive deficit.
HumanSkeletal muscle
Endlicher 2017 MiP20172017
Rene Endlicher
Age-related changes in isolated mitochondria from rat liver.
RatLiver
Laner 2017 Abstract EUROMIT2017 Cologne2017
EUROMIT2017
K-Regio MitoFit and MitoEAGLE – towards a global data bank on mitochondrial physiology.
Human
Michalak 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.
HumanBlood cells
Klepinin 2017 MiP20172017
MiPsociety
Novel method to study the role of the adenylate kinase network in health and disease.
Human
Rat
Heart
Stem cells
Ost 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Novel multivariate biomarkers of age-dependent sarcopenia: A blood based bioenergetics & cytokine profiling approach.
Human
Mouse
Blood cells
Lemieux 2017 MiP20172017
Helene Lemieux
Compounding effects of age and sexual dimorphism on cardiac mitochondrial function in type 2 diabetes.
RatHeart
Ukropec 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment?
Skeletal muscle
Arandarcikaite 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Age-related responses of brain mitochondria to ischemic insult. Arandarcikaite_Presenation
RatNervous system
Marcinek 2016 Abstract MitoFit Science Camp 20162016Targeting mitochondrial redox stress reveals two phases for reversal of mitochondrial dysfunction in aged mouse skeletal muscle.MouseSkeletal muscle
Sparagna 2016 Abstract IOC1092016Sparagna GC (2016) Measuring cardiac mitochondrial function in pediatric patients before and after implantation of a left ventricular assist device. Mitochondr Physiol Network 21.01.HumanHeart
Calzia 2016 Abstract MitoFit Science Camp 20162016Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains.FishesHeart
Skeletal muscle
Nervous system
Liver
Gnaiger 2016 Abstract EBEC Riva del Garda 20162016MitoFit and MitoEAGLE – towards a global data bank on mitochondrial physiology.
Tepp 2015 Abstract MiP20152015Changes in energy transfer regulation during development and aging.Heart
Volt 2014 Abstract SECF2014Experimental basis for the “inflammaging” theory.MouseHeart
Dohlmann 2014 Abstract MiP20142014Mitochondrial adaptations to high-intensity training in young and elderly men and women.HumanSkeletal muscle
HeLa
Fibroblast
Volt 2014 Abstract The 2014 Ageing Summit2014Effects of melatonin on the age-dependent dysregulation of the Nf-Kb/Nlrp3 activation during sepsis.MouseHeart
Paju 2014 Abstract MiP20142014Characterization of the effects of pro-inflammatory cytokines on energy metabolism in human myoblasts.HumanSkeletal muscle
Hepple 2014 Abstract MiP20142014Denervation modulates mitochondrial function when aging muscle atrophy becomes severe: implications for therapeutic intervention.HumanSkeletal muscle
Spendiff 2014 Abstract MiP20142014Lessons from the master athlete: mitochondrial contributions to aging.HumanSkeletal muscle
Wohlwend 2014 Abstract MiP20142014Exercise modality specific mitochondrial adaptations in skeletal muscle of elderly people.HumanSkeletal muscle
Brandt 2013 Abstract MiP20132013Brandt T, Mourier A, Stewart JB, Larsson NG, KĂŒhlbrandt W (2013) Structure and function of aged mouse mitochondria. Mitochondr Physiol Network 18.08.MouseHeart
Liver
Kidney
Skulachev 2013 Abstract MiP20132013Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08.Human
Mouse
Horse
Dog
Rabbit
Fishes
Other invertebrates
Fungi
Plants
Heart
Skeletal muscle
Nervous system
Kidney
Islet cell;pancreas;thymus
Other cell lines
HeLa
Fibroblast
Stem cells
Beach 2013 Abstract MiP20132013Beach A, Richard VR, Leonov A, Burstein MT, Feldman R, Gentile C, Titorenko VI (2013) Lithocholic acid delays aging in yeast and exhibits an anti-tumor effect in human cells by altering mitochondrial composition, structure and function. Mitochondr Physiol Network 18.08.Human
Saccharomyces cerevisiae
Other cell lines
Neuroblastoma
Oliveira MF 2013 Abstract MiP20132013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma
Camacho-Pereira 2013 Abstract IOC752013Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03.MouseLiver
HEK
Macrophage-derived
Pichaud 2013 Abstract MiP20132013Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.Drosophila
Hexapods
Skeletal muscle
Hendricks 2013 Abstract MiP20132013Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08.MouseNervous system
Quistorff 2013 Abstract MiP20132013Quistorff B (2013) With type 2 diabetes mitochondrial dysfunction develops earlier in liver than in skeletal muscle. Mitochondr Physiol Network 18.08.RatSkeletal muscle
Liver
Boushel 2013 Abstract MiP20132013Boushel RC (2013) Convective O2 delivery, diffusion and mitochondrial OXPHOS components of VO2 during exercise in health and disease. Mitochondr Physiol Network 18.08.HumanSkeletal muscle
Cavalcanti de Albuquerque 2013 Abstract MiP20132013Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.RatSkeletal muscle
Albertini 2012 Abstract Bioblast2012Albertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12.Endothelial;epithelial;mesothelial cell
HUVEC
Distefano 2012 Abstract IOC682012Distefano G, Dube JJ, Helbling NL, Ritov VB, Stefanovic-Racic M, Toledo FGS, Ng J, Goodpaster BH, Coen PM (2012) Human skeletal muscle mitochondria respiration: The influence of aging, adiposity and aerobic fitness. MiPNet17.08.HumanSkeletal muscle
Hepple 2012 Abstract Bioblast2012Hepple RT, Picard M, Taivassalo T (2012) Is latent mitochondrial dysfunction in aging muscle exposed through mitochondrial isolation? Mitochondr Physiol Network 17.12.Skeletal muscle
Acuna-Castroviejo 2012 Abstract Bioblast2012Acuna-Castroviejo D (2012) Melatonin and the quality of life: the melatonin-mitochondrion connection. Mitochondr Physiol Network 17.12.Mouse
Rat
Heart
Skeletal muscle
Nervous system
Liver
Kiss 2012 Abstract Bioblast2012Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C (2012) The negative impact of alpha-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. Mitochondr Physiol Network 17.12.MouseNervous system
Liver
Watala 2012 Abstract Bioblast2012Watala C, Przygodzki T, Siewiera K, Kassassir H, Talar M, Labieniec-Watala M (2012) Oxygen consumption in resting and activated blood platelets: platelet mitochondria and cyclooxygenases as compounding targets for high-resolution respirometry. Mitochondr Physiol Network 17.12.Human
Rat
Endothelial;epithelial;mesothelial cell
Blood cells
Platelet
Koziel 2012 Abstract Bioblast2012Koziel R, Pircher H, Kratochwil M, Lener B, Hermann M, Dencher N.A, Jansen-Durr P (2012) NADPH oxidase Nox4 induces mitochondrial dysfunction in human endothelial cells. Mitochondr Physiol Network 17.12.HUVEC
Gnaiger 2005 Abstract MiP20052005Gnaiger Erich, Wright-Paradis C, Sondergaard H, Lundby C, Calbet Jose AL, Saltin Bengt, Helge J, Boushel R (2005) High-resolution respirometry in small biopsies of human muscle: correlations with body mass index and age. MiP2005.HumanSkeletal muscle

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