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• Gustafson 1986 J Biol Chem
  ...tty acyl-CoA dehydrogenase, electron transfer flavoprotein, and fatty acyl-CoA substrates. J Biol Chem 261:7733-41 ...A substrates and GAD are essentially isopotential. The ability of octanoyl-CoA to reduce GAD quantitatively (Keq = 9.0) poses a dilemma in light of the ne
  2 KB (278 words) - 15:49, 22 March 2023
• Zhang 2019 Redox Biol
  ...ME, Goetzman ES (2019) The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Redox Biol 26:101253. ...resence of LCAD drives H₂O₂ formation in response to fatty acids in these tissues.
  2 KB (344 words) - 09:30, 23 August 2021
• 3-Mercaptopropionic acid
  |description=3-Mercaptopropionic acid (MPA) inhibits long chain [[acyl-CoA dehydrogenase]]s (ACADs). ...an ES, Vockley J (2010) Evidence for physical association of mitochondrial fatty acid oxidation and oxidative phosphorylation complexes. J Biol Chem 285:298
  521 bytes (61 words) - 08:41, 17 March 2023
• Crane 1956 J Biol Chem
  ...le=Crane FL, Beinert H (1956) On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. II. The electron-transferring flavoprotein. J Bi ...ctron acceptor in the present system and the role of copper in butyryl CoA dehydrogenase.
  2 KB (271 words) - 09:44, 8 May 2023
• Van Eunen 2013 PLoS Comput Biol
  ...n BK, Krab K, Reijngoud DJ, Bakker BM (2013) Biochemical competition makes fatty-acid β-oxidation vulnerable to substrate overload. PLoS Comput Biol 9:e100 ...ereby led to accumulation of CoA-ester intermediates and depletion of free CoA (CoASH). The mitochondrial [NAD⁺]/[NADH] ratio modulated the sensitivity
  4 KB (524 words) - 17:15, 12 February 2018
• Goetzman 2011 Prog Mol Biol Transl Sci
  |title=Goetzman ES (2011) Modeling disorders of fatty acid metabolism in the mouse. Prog Mol Biol Transl Sci 100:389-417. https:/ ...ivated receptor-α and sirtuin-3. Finally, nongenetic means of manipulating fatty acid oxidation in the mouse are discussed, in particular the various chemic
  2 KB (276 words) - 16:16, 29 October 2023
• Toogood 2004 J Biol Chem
  ...sfer in the human electron transferring flavoprotein.medium chain Acyl-CoA dehydrogenase complex. J Biol Chem 279:32904-12. https://doi.org/10.1074/jbc.M404884200 ...tible with fast interprotein electron transfer. Disorders in amino acid or fatty acid catabolism can be attributed to mutations at the protein-protein inter
  4 KB (505 words) - 18:26, 6 September 2023
• Ojuka 2015 Abstract MiPschool Cape Town 2015
  |title=Use of malate or carnitine as co-substrates for assessment of fatty acid oxidation. |abstract=Acylcarnitines when converted to acyl –CoA in the mitochondrial matrix
  3 KB (438 words) - 16:16, 26 March 2018
• Kakimoto 2015 Redox Biol
  ...a SR, Kowaltowski AJ (2015) H2O2 release from the very long chain acyl-CoA dehydrogenase. Redox Biol 4:375-80. ...x pH of ~8.5. Using recombinantly expressed human very long chain acyl-CoA dehydrogenase, we are able to demonstrate that palmitate-induced H2O2 release may be ascr
  2 KB (237 words) - 09:25, 23 August 2021
• Smith 2011 Biochem J
  ...s located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation. Biochem J 437:125-34. ...yl-CoA synthetase, thereby contributing to the regulation of mitochondrial fatty-acid transport. We further support this model by providing evidence that FA
  2 KB (327 words) - 14:47, 13 February 2015
• Van Eunen 2016 BMC Biol
  ...e edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders. BMC Biol 14:107. |abstract=Defects in genes involved in mitochondrial fatty-acid oxidation (mFAO) reduce the ability of patients to cope with metabolic
  4 KB (583 words) - 17:17, 12 February 2018
• 2-mercaptoacetate
  ...arnitine]] oxidation. 2-mercaptoacetate has been used as an inhibitor of [[fatty acid oxidation]] ([[F-pathway control state]]). In permeabilized rat soleus
  723 bytes (84 words) - 17:08, 18 January 2022
• Lou 2017 Physiol Rep
  ...hi M, Hersberger M, Clanachan AS, Lemieux H, Zaugg M (2017) Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic he ...that the heart is no longer capable of further increasing its capacity for fatty acid oxidation. Along with increased oxidative stress, this may represent o
  3 KB (375 words) - 14:55, 11 December 2017
• Moon 2012 J Biol Chem
  ...tochondria from iPLA_2γ(-/-) mice were insensitive to fatty acyl-CoA mediated augmentation of calcium-induced mPTP opening. Moreover, mitochondr ...a permeability transition, Reactive oxygen species, Cytochrome ''c'', Acyl-CoA
  3 KB (432 words) - 15:26, 13 November 2017
• Fatty acid oxidation pathway control state
  ...to mitochondrial ''β''-oxidation. Oxygen consumption by peroxisomal [[acyl-CoA oxidase]] is considered as [[residual oxygen consumption]] rather than cell ::::» [[Talk:Fatty acid oxidation |O2k-Network discussion forum: fatty acids used in permeabilized fibre assays]]
  3 KB (456 words) - 16:12, 13 January 2022
• Watmough 2010 Biochim Biophys Acta
  ...h a mild and late onset variant of the metabolic disease multiple acyl-CoA dehydrogenase deficiency (MADD). ...This potential for cross-talk may provide the basis for the regulation of fatty acid oxidization by the cytosolic [NAD+]/[NADH] ratio [11,12].
  3 KB (483 words) - 08:17, 13 September 2023
• F-junction
  ...he absence of malate. Malate is oxidized in a reaction catalyzed by malate dehydrogenase to oxaloacetate (yielding NADH), which then stimulates the entry of AcetylC
  1 KB (202 words) - 17:06, 18 January 2022
• Cecatto 2016 Toxicol In Vitro
  ...of mitochondrial functions provoked by the major long-chain 3-hydroxylated fatty acids accumulating in MTP and LCHAD deficiencies in skeletal muscle. Toxico ...stigated the effects of the major long-chain monocarboxylic 3-hydroxylated fatty acids (LCHFA) accumulating in these disorders, namely 3-hydroxytetradecanoi
  3 KB (335 words) - 08:35, 24 September 2021
• Hoppel 2017 MiP2017
  ...mage:Hoppel 2012x.jpg|left|90px|Charles Hoppel]] Pathways of mitochondrial fatty acid oxidation. [[Media:Hoppel Presentation.pdf|Hoppel_Presentation]] ...erase 1a (CPT1a, an integral outer membrane protein), which converts fatty acyl-CoAs into acylcarnitines.
  5 KB (659 words) - 16:48, 12 December 2017
• Ludzki 2015 Diabetes
  ...ufer PD, Holloway GP (2015) Rapid repression of ADP transport by palmitoyl-CoA is attenuated by exercise training in humans; a potential mechanism to decr ...in resistance and highlight the ability of exercise training to diminish P-CoA attenuation in mitochondrial ADP transport.
  3 KB (367 words) - 09:20, 8 November 2016

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