ET-reserve control efficiency: Difference between revisions
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{{MitoPedia | |||
|abbr=''j<sub>E-R</sub>'' | |||
|description=[[Image:jExR.jpg|50 px|ET-reserve control efficiency]] The apparent '''ET-reserve control efficiency''' (''E-R'' control efficiency), ''j<sub>E-R</sub>'' = (''E-R'')/''E'' = 1-''R/E'', is an expression of the relative scope of increasing [[ROUTINE respiration]] in living cells by uncoupling. ''j<sub>E-R</sub>'' = 0.0 for zero excess capacity when ''R''=''E''; ''j<sub>E-R</sub>'' = 1.0 for the maximum limit when ''R''=0. The [[ROUTINE]] state of living cells is stimulated to [[electron transfer pathway]] by [[uncoupler]] titration, which yields the [[ET-reserve capacity]] ''E-R''. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by '''[[cell ergometry]]'''), ''j<sub>E-R</sub>'' is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve) for uncoupling respiration. Similarly, the apparent [[ET-excess capacity]] ''E-P'' is not a respiratory reserve in the sense of oxidative phosphorylation. | |||
|info=[[Flux control efficiency]] | |||
}} | |||
== Compare == | |||
:::» [[ROUTINE-control ratio]] ''R/E'' | |||
:::» [[ET-excess coupling efficiency]] ''j<sub>E-P</sub>'' = (''E-P'')/''E'' = 1-''P/E'' | |||
:::» [[ET-coupling efficiency]] ''j<sub>E-L</sub>'' = 1-''L/E'' | |||
{{MitoPedia concepts | |||
|mitopedia concept=Respiratory control ratio | |||
}} | |||
[[Category:Coupling control]] | |||
Revision as of 22:36, 8 November 2020
- high-resolution terminology - matching measurements at high-resolution
ET-reserve control efficiency
Description
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The apparent ET-reserve control efficiency (E-R control efficiency), jE-R = (E-R)/E = 1-R/E, is an expression of the relative scope of increasing ROUTINE respiration in living cells by uncoupling. jE-R = 0.0 for zero excess capacity when R=E; jE-R = 1.0 for the maximum limit when R=0. The ROUTINE state of living cells is stimulated to electron transfer pathway by uncoupler titration, which yields the ET-reserve capacity E-R. Since ET-capacity is significantly higher than OXPHOS capacity in various cell types (as shown by cell ergometry), jE-R is not a reserve capacity available for the cell to increase oxidative phosphorylation, but strictly a scope (reserve) for uncoupling respiration. Similarly, the apparent ET-excess capacity E-P is not a respiratory reserve in the sense of oxidative phosphorylation.
Abbreviation: jE-R
Reference: Flux control efficiency
Compare
- » ROUTINE-control ratio R/E
- » ET-excess coupling efficiency jE-P = (E-P)/E = 1-P/E
- » ET-coupling efficiency jE-L = 1-L/E
MitoPedia concepts: Respiratory control ratio
