The body mass excess, BME, is an index of obesity and as such BME is a lifestyle metric. The BME with respect to the healthy reference population, HRP, is defined as BME ≝ ΔM/M°. ΔM is the excess body mass exceeding the reference body mass, M°, in the HRP. Thus the BME is a measure of the extent to which your actual body mass, M [kg/x], deviates from M° [kg/x], which is the reference body mass [kg] per individual [x] without excess body fat. The BME is expressed relative to the reference body mass for your height, H [m]. A balanced BME is BME° = 0.0 with a band width of -0.1 towards underweight and +0.2 towards overweight. The BME is linearly related to the body fat excess.
Reference: Gnaiger 2019 MiP2019
|Healthy reference population||Body mass excess||BFE||BME cutoffs||BMI||H||M||VO2max||mitObesity drugs|
- 1 Description
- 2 Body mass excess in relation to the allometry of the healthy reference population
- 3 MitoPedia: BME and mitObesity
Body mass excess in relation to the allometry of the healthy reference population
Work in progress by Gnaiger E 2020-02-10 linked to a preprint in preparation on BME and mitObesity.
- The body mass index, BMI = M·H-2 [kg·m-2], is a globally applied metric for evaluation of undernutrition or overweight and obesity (NCD-RisC 2017 Lancet). The WHO recommends the use of BMI cutoff points of 25 and 30 kg·m-2 for categorization of overweight and obese states in adults world-wide (WHO Expert Consultation 2004 Lancet), despite of critical assessments of the need to adjust BMI cutoffs to lower values in Asian populations and differentiate BMI cutoff values for women and men (WHO 2000 Sydney Health Comm AU; Nevill 2015 Nutr Diabetes; Mialich 2018 J Electr Bioimp).
- The body mass excess, BME, is an index of the relative deviation of the actual body mass, M [kg], from the reference body mass, M° [kg], at a given height in the healthy reference population (Fig. 1),
Eq. 1: BME = (M-M°)/M°
- In contrast to the BMI, therefore, the BME provides an evidence-based index of underweight, overweight and obesity across all heights and ages, applicable to all populations for which the healthy reference baseline is established.
BME - the body mass excess calculator
Note: BME is now defined as ΔM/M° = (M-M°)/M° = M/M°-1, in contrast to our previous definition as M/M°.
» BME calculator Erich Gnaiger and Paolo Cocco - last update 2020-01-07
- Example: BME and precision-BMI cutoff points
- Considering a height of 1.78 m, the balanced body mass is M° = 65.9 kg per individual, and overweight is reached at a weight gain of 20 % or BME = 0.2: (1+0.2)·M° = 79 kg per individual. The corresponding precision-BMI cutoff poin for overweight is BMI0.2 = 65.9/1.782 = 24.9 kg/m2.
- At a height of 1.84 m, the balanced body mass is M° = 72.4 kg/x, and obesity is reached at a weight gain of 40 % or BME = 0.4. 1.4·M° = 101.4 kg/x. The corresponding precision-BMI cutoff poin for obese is BMI0.4 = 72.4/1.842 = 29.9 kg/m2.
- The BME calculator
- The BME calculator is based on the WHO database on children up to 10 years of age (WHO Multicentre Growth Reference Study Group, WHO MGRS 2006), and on the Committee on Biological Handbooks data set (CBH; Zimmer 1962) on adoselscents to adults (Fig. 1), according to the tables listed below. The results have to be critically evaluated. The BME calculator applies to healthy controls (except for obesity), without sarcopenia.
- Open the BME calculator by clicking here (press Ctrl and left mouse click): BME calculator
- Click into the field Height, H [m], and enter your height in meters [m] (not cm), using the dot (not the comma) as a separator for two decimal places. Do not enter more than two decimal places. Example: 1.70 m
- Click into the field Body mass, M [kg/x], and enter your mass (weight) in kilograms [kg] (not pounds), using the dot (not the comma) as a separator for the decimal place. Example: 63.4 kg/x
- Click into the field Click here for results. This activates the caclulator. Results are displayed in the fields below.
- The body mass excess, BME, is calculated from your height and body mass. Example BME=0.1: With a BME of 0.1 you are 10 % above the reference body mass, which is well within the normal range. The percentage is calculated as BME*100.
- For comparison with the commonly used Body mass index, BMI [kg/m2], the BMI is calculated from your body mass divided by your height squared. Example BMI=21.9 kg/m2: What does this index tell you?
- The expected maximum aerobic exercise capacity per body mass, VO2max/M, at a BME of 0.1 is 55 mL·min-1·kg-1. The calculated VO2max/M applies to healthy adults, and does not apply to BME<0.
- At BME=0.0, the reference body mass, M°, is calculated from your height and shows the corresponding body mass of a person from the healthy reference population. Example M°=57.7 kg/x: Compare your measured body mass of 63.4 kg/x with the reference body mass of 57.7 kg/x.
- At BME=0.2 and 0.4, the overweight body mass, 1.2M°, and obese body mass, 1.4M°, are calculated from the reference body mass. You can compare these cutoff values with your actual body mass. Example 1.2M°=69.2 kg/x: More than 69.2 kg/x is rated as overweight for a height of 1.70 m/x with BME=0.2. 1.4M°=80.8 kg/x: More than 80.8 kg/x is rated as obese for a height of 1.70 m/x with BME=0.4.
- If you want to edit the height or body mass entered above, click into the corresponding field, delete the previously entered number, enter the new number, and click into the field Click here for results.
Body mass excess (BME) compared to body mass index (BMI)
- Balanced standard: BME = 0.0
- Overweight: BME > 0.2
- Obese: BME > 0.4
- The concept of BME is related to maximum ergometric capacity and mitochondrial fitness (Gnaiger 2019 MiP2019).
- For heights of 0.45 to 1.26 m per newborn or child, the tables are based on data for WHO Child Growth Standards (WHO MGRS: WHO 2006 Acta Paediatr; WHO 2006 Geneva: World Health Organization) compiled from Brazil, Ghana, India, Norway, Oman and the USA, reporting as little as 3 % differences between these groups studied in affluent neighborhoods and raised in environments that do not constrain growth (WHO 2006 Acta Paediatr). At the same height the body mass of girls and boys differs less than ±2 % from the common fitted curve, except for a difference of +3 % for boys at 0.70 to 0.77 m/x and -3 % for girls at 0.62 to 0.64 m/x.
- For heights of 1.27 m/x and above, the tables are based on the Committee on Biological Handbooks data set (CBH; Zucker 1962 Committee on Biological Handbooks, Fed Amer Soc Exp Biol), compiled from publications between 1931 to 1944 (Healthy reference population). These agree with WHO-CGS data at heights 1.27 to 1.4 m per child or adolescent (WHO 2006 Geneva: World Health Organization) within better than 2 %, and agree on noting no difference in the curves for females and males, but adult females do not reach the same height as males. Body mass and height are not different in girls and boys at the corresponding age of 8 to 10 years.
BME at height 0.45 - 0.62 m/x
BME at height 0.63 - 1.02 m/x
BME at height 1.03 - 1.26 m/x
BME at height 1.27 - 2.0 m/x
- Based on Biological Handbooks (Zucker 1962 Committee on Biological Handbooks, Fed Amer Soc Exp Biol), extrapolated >1.8 m: M° = 12.68·H2.857
- The circled numbers emphasize the precision-BMI cutoff points used for harmonization between BME cutoff points and conventional BMI cutoff values, at 1.70 m/x for the normal BMI of 20 kg·m-2, at 1.79 m/x for the overweight BMI of 25 kg·m-2, and at 1.84 m/x for the obese BMI of 30 kg·m-2.
Sort in ascending/descending order by a click on one of the small symbols in squares below. Default sorting: chronological. Empty fields appear first in ascending order.
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MitoPedia: BME and mitObesity
» Body mass excess and mitObesity | BME and mitObesity news | Summary |
|BME cutoff points||BME cutoff||Obesity is defined as a disease associated with an excess of body fat with respect to a healthy reference condition. Cutoff points for body mass excess, BME cutoff points, define the critical values for underweight (-0.1 and -0.2), overweight (0.2), and various degrees of obesity (0.4, 0.6, 0.8, and above). BME cutoffs are calibrated by crossover-points of BME with established BMI cutoffs.|
|Body fat excess||BFE||In the healthy reference population (HRP), there is zero body fat excess, BFE, and the fraction of excess body fat in the HRP is expressed - by definition - relative to the reference body mass, M°, at any given height. Importantly, body fat excess, BFE, and body mass excess, BME, are linearly related, which is not the case for the body mass index, BMI.|
|Body mass||m [kg]; M [kg·x-1]||The body mass, M, is the mass (kilogram [kg]) of an individual (object) [x] and is expressed in units [kg/x]. Whereas the body weight changes as a function of gravitational force (you are weightless at zero gravity; your floating weight in water is different from your weight in air), your mass is independent of gravitational force, and it is the same in air and water.|
|Body mass excess||BME||The body mass excess, BME, is an index of obesity and as such BME is a lifestyle metric. The BME is a measure of the extent to which your actual body mass, M [kg/x], deviates from M° [kg/x], which is the reference body mass [kg] per individual [x] without excess body fat in the healthy reference population, HRP. A balanced BME is BME° = 0.0 with a band width of -0.1 towards underweight and +0.2 towards overweight. The BME is linearly related to the body fat excess.|
|Body mass index||BMI||The body mass index, BMI, is the ratio of body mass to height squared (BMI=M·H-2), recommended by the WHO as a general indicator of underweight (BMI<18.5 kg·m-2), overweight (BMI>25 kg·m-2) and obesity (BMI>30 kg·m-2). Keys et al (1972; see 2014) emphasized that 'the prime criterion must be the relative independence of the index from height'. It is exactly the dependence of the BMI on height - from children to adults, women to men, Caucasians to Asians -, which requires adjustments of BMI-cutoff points. This deficiency is resolved by the body mass excess relative to the healthy reference population.|
|Comorbidity||Comorbidities are common in obesogenic lifestyle-induced early aging. These are preventable, non-communicable diseases with strong associations to obesity. In many studies, cause and effect in the sequence of onset of comorbidities remain elusive. Chronic degenerative diseases are commonly obesity-induced. The search for the link between obesity and the etiology of diverse preventable diseases lead to the hypothesis, that mitochondrial dysfunction is the common mechanism, summarized in the term 'mitObesity'.|
|Healthy reference population||HRP||A healthy reference population, HRP, establishes the baseline for the relation between body mass and height in healthy people of zero underweight or overweight, providing a reference for evaluation of deviations towards underweight or overweight and obesity. The WHO Child Growth Standards (WHO-CGS) on height and body mass refer to healthy girls and boys from Brazil, Ghana, India, Norway, Oman and the USA. The Committee on Biological Handbooks compiled data on height and body mass of healthy males from infancy to old age (USA), published before emergence of the fast-food and soft-drink epidemic. Four allometric phases are distinguished with distinct allometric exponents. At heights above 1.26 m/x the allometric exponent is 2.9, equal in women and men, and significantly different from the exponent of 2.0 implicated in the body mass index, BMI [kg/m2].|
|Height of humans||h [m]; H [m·x-1]||The height of humans, h, is given in SI units in meters [m]. Humans are countable objects, and the symbol and unit of the number of objects is N [x]. The average height of N objects is, H = h/N [m/x], where h is the heights of all N objects measured on top of each other. Therefore, the height per human has the unit [m·x-1] (compare body mass [kg·x-1]). Without further identifyer, H is considered as the standing height of a human, measured without shoes, hair ornaments and heavy outer garments.|
|MitObesity drugs||Bioactive mitObesity compounds are drugs and nutraceuticals with more or less reproducible beneficial effects in the treatment of diverse preventable degenerative diseases implicated in comorbidities linked to obesity, characterized by common mechanisms of action targeting mitochondria.|
|Obesity||Obesity is a disease resulting from excessive accumulation of body fat. In common obesity (non-syndromic obesity) excessive body fat is due to an obesogenic lifestyle with lack of physical exercise ('couch') and caloric surplus of food consumption ('potato'), causing several comorbidities which are characterized as preventable non-communicable diseases. Persistent body fat excess associated with deficits of physical activity induces a weight-lifting effect on increasing muscle mass with decreasing mitochondrial capacity. Body fat excess, therefore, correlates with body mass excess up to a critical stage of obesogenic lifestyle-induced sarcopenia, when loss of muscle mass results in further deterioration of physical performance particularly at older age.|
|VO2max||VO2max; VO2max/M||Maximum oxygen consumption, VO2max, is and index of cardiorespiratory fitness, measured by spiroergometry on human and animal organisms capable of controlled physical exercise performance on a treadmill or cycle ergometer. VO2max is the maximum respiration of an organism, expressed as the volume of O2 at STPD consumed per unit of time per individual object [mL.min-1.x-1]. If normalized per body mass of the individual object, M [kg.x-1], mass specific maximum oxygen consumption, VO2max/M, is expressed in units [mL.min-1.kg-1].|
MitoPedia concepts: MiP concept