Donnarumma 2022 Nat Commun

Donnarumma E, Kohlhaas M, Vimont E, Kornobis E, Chaze T, Gianetto QG, Matondo M, Moya-Nilges M, Maack C, Wai T (2022) Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure. https://doi.org/10.1038/s41467-022-34316-3

» Nat Commun 13:6634. PMID: 36333300 Open Access

Donnarumma Erminia, Kohlhaas Michael, Vimont Elodie, Kornobis Etienne, Chaze Thibault, Gianetto Quentin Giai, Matondo Mariette, Moya-Nilges Maryse, Maack Christoph, Wai Timothy (2022) Nat Commun

Abstract: Mitochondria are paramount to the metabolism and survival of cardiomyocytes. Here we show that Mitochondrial Fission Process 1 (MTFP1) is an inner mitochondrial membrane (IMM) protein that is dispensable for mitochondrial division yet essential for cardiac structure and function. Constitutive knockout of cardiomyocyte MTFP1 in mice resulted in a fatal, adult-onset dilated cardiomyopathy accompanied by extensive mitochondrial and cardiac remodeling during the transition to heart failure. Prior to the onset of disease, knockout cardiac mitochondria displayed specific IMM defects: futile proton leak dependent upon the adenine nucleotide translocase and an increased sensitivity to the opening of the mitochondrial permeability transition pore, with which MTFP1 physically and genetically interacts. Collectively, our data reveal new functions of MTFP1 in the control of bioenergetic efficiency and cell death sensitivity and define its importance in preventing pathogenic cardiac remodeling.

• Bioblast editor: Plangger M

Labels: MiParea: Respiration 

HRR: Oxygraph-2k 

2022-11