Lu 2018 Cell Rep: Difference between revisions
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{{Publication | {{Publication | ||
|title=Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H | |title=Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52. | ||
|info=[https://www.ncbi.nlm.nih.gov/pubmed/30089272 PMID: 30089272] | |info=[https://www.ncbi.nlm.nih.gov/pubmed/30089272 PMID: 30089272 Open Access] | ||
|authors=Lu | |authors=Lu Zongshi, Cui Yuanting, Wei Xing, Gao Peng, Zhang Hexuan, Wei Xiao, Li Qiang, Sun Fang, Yan Zhencheng, Zheng Hongting, Yang Gangyi, Liu Daoyan, Zhu Zhiming | ||
|year=2018 | |year=2018 | ||
|journal=Cell Rep | |journal=Cell Rep | ||
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|pathways=N, S, NS, ROX | |pathways=N, S, NS, ROX | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=Labels, 2018-08, | |additional=Labels, 2018-08, CN, Alert2020, | ||
}} | }} |
Latest revision as of 20:20, 29 February 2020
Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52. |
Lu Zongshi, Cui Yuanting, Wei Xing, Gao Peng, Zhang Hexuan, Wei Xiao, Li Qiang, Sun Fang, Yan Zhencheng, Zheng Hongting, Yang Gangyi, Liu Daoyan, Zhu Zhiming (2018) Cell Rep
Abstract: High salt intake is one independent risk factor for cardiac hypertrophy. Polycystic kidney disease 2-like 1 (PKD2L1, also called TRPP3) acts as a sour sensor in taste cells, and its possible role in the cardiovascular system is unknown. Here, we report that knockout of PKD2L1 exacerbated high-salt diet (HSD)-induced cardiac hypertrophy and fibrosis, accompanied by cardiac dysfunction and reduced cardiac mitochondrial oxidative phosphorylation and enzyme activity. Furthermore, knockdown of PKD2L1 led to more serious mitochondrial Ca2+ overload and reduced Ca2+ uptake in cardiomyocytes on high salt loading. Mechanistically, PKD2L1 deficiency increased p300-mediated acetylation of histone 3 lysine 27 on the promoter of sodium/calcium exchange 1 (NCX1) by repressing AMP-activated protein kinase (AMPK) activity, resulting in NCX1 overexpression and mitochondrial Ca2+ overload. These results reveal an inhibitory effect of PKD2L1 on cardiac hypertrophy and provide a mechanistic insight into the link between mitochondrial Ca2+ homeostasis and cardiac hypertrophy. โข Keywords: NCX1, PKD2L1, Cardiac hypertrophy, High-salt diet, Mitochondria โข Bioblast editor: Kandolf G โข O2k-Network Lab: CN Chongqing Zhu Z
Labels: MiParea: Respiration, nDNA;cell genetics, Genetic knockout;overexpression, Exercise physiology;nutrition;life style
Pathology: Cardiovascular
Organism: Mouse Tissue;cell: Heart Preparation: Isolated mitochondria
Regulation: Calcium Coupling state: LEAK, OXPHOS, ET Pathway: N, S, NS, ROX HRR: Oxygraph-2k
Labels, 2018-08, CN, Alert2020