Menna-Barreto 2022 Abstract Bioblast: Difference between revisions
m (Gnaiger Erich moved page Menna barreto 2022 Abstract Bioblast to Menna-Barreto 2022 Abstract Bioblast) |
Tindle Lisa (talk | contribs) No edit summary |
||
Line 1: | Line 1: | ||
[[File:Bioblast2022 banner.jpg|link=Bioblast_2022]] | [[File:Bioblast2022 banner.jpg|link=Bioblast_2022]] | ||
{{Abstract | {{Abstract | ||
|title=Bombaça ACS, <u>Menna-Barreto Rubem FS</u> (2022) Mitochondrial plasticity in trypanosomatids as a stress adaptation mechanism. Bioblast 2022: BEC Inaugural Conference.<br>[[Bombaca 2022 MitoFit|»''MitoFit Preprint''«]]  | |title=[[File:Menna-Barreto R.jpg|left|100px|Menna-Barreto Rubem]]Bombaça ACS, <u>Menna-Barreto Rubem FS</u> (2022) Mitochondrial plasticity in trypanosomatids as a stress adaptation mechanism. Bioblast 2022: BEC Inaugural Conference.<br>[[Bombaca 2022 MitoFit|»''MitoFit Preprint''«]]  | ||
|info=[https://wiki.oroboros.at/index.php/Bioblast_2022#Submitted_abstracts Bioblast 2022: BEC Inaugural Conference] | |info=[https://wiki.oroboros.at/index.php/Bioblast_2022#Submitted_abstracts Bioblast 2022: BEC Inaugural Conference] | ||
|authors=Bombaca Ana Cristina S, Menna Barreto Rubem | |authors=Bombaca Ana Cristina S, Menna-Barreto Rubem | ||
|year=2022 | |year=2022 | ||
|event=[[Bioblast 2022]] | |event=[[Bioblast 2022]] |
Revision as of 10:17, 31 May 2022
Bombaça ACS, Menna-Barreto Rubem FS (2022) Mitochondrial plasticity in trypanosomatids as a stress adaptation mechanism. Bioblast 2022: BEC Inaugural Conference. »MitoFit Preprint« |
Link: Bioblast 2022: BEC Inaugural Conference
Bombaca Ana Cristina S, Menna-Barreto Rubem (2022)
Event: Bioblast 2022
Neglected tropical diseases impact more than a billion people globally, with millions of them at risk of infection by parasites of the Trypanosomatidae family. The need to colonize different environments in their hosts means that trypanosomatids are constantly subjected to stress situations, among which the presence of reactive oxygen (ROS) and nitrogen (RNS) species, requiring intense metabolic remodeling to ensure the parasites survival in hostile environments. Additionaly to the classical role in bioenergetics, mitochondrion has a decisive contribution to the oxidative stress, due to the electron leakage from the electron transfer system (ETS). The presence of several functional peculiarities made the mitochondrion of trypanosomatids an unique organelle, considered an excellent target for drug intervention. Some trypanosomatids such as Leishmania spp. can avoid the microbicidal mechanisms of the host cells, exhibiting a profile of natural resistance to oxidative and nitrosative stresses. Here, we discussed data about mitochondrial susceptibility and adaptative processes obtained by our group in the last 17 years. Mechanistic proposals of preclinical drugs was reviewed, as well as different pathways associated with metabolic and mitochondrial remodeling during the life cycle of trypanosomatids, including the possible biological role of ROS and RNS resistance and its impact on the interaction with vertebrate and invertebrate hosts.
β’ Keywords: trypanosomatids, mitochondrion, bioenergetics, oxidative stress, chemotherapy
Affiliations
- Bombaça ACS1,2, Menna-Barreto RFS2
- Laboratório de Estudos Integrados em Protozoologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil - [email protected]
- Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
- Bombaça ACS1,2, Menna-Barreto RFS2
Figures
List of abbreviations, terms and definitions - MitoPedia
Labels: MiParea: Comparative MiP;environmental MiP
Pathology: Other
Organism: Protists
Trypanosoma