Difference between revisions of "NS e-input"

Latest revision as of 18:49, 1 January 2021

high-resolution terminology - matching measurements at high-resolution

NS e-input

Description

NS e-input or the NS-pathway control state is electron input from a combination of substrates for the N-pathway control state and S-pathway control state through Complexes CI and CII simultaneously into the Q-junction. NS e-input corresponds to TCA cycle function in vivo, with convergent electron flow through the Electron transfer pathway. In mt-preparations, NS e-input requires addition not only of NADH- (N-) linked substrates (pyruvate&malate or glutamate&malate), but of succinate (S) simultaneously, since metabolite depletion in the absence of succinate prevents a significant stimulation of S-linked respiration. For more details, see: Additive effect of convergent electron flow.

Abbreviation: NS, CI&II

Reference: Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol

MitoPedia concepts: MiP concept, SUIT concept

From CI&II e-input to NS e-input

» Terminology

@@ Line 1: / Line 1: @@
-Electron input though Complexes [[CI]] plus [[CII]] simultaneously into the [[Q-junction]] corresponds to [[TCA cycle]] function in vivo, with [[convergent electron flow]] through the [[ETS]].  In [[mt-preparations]], CI+II e-input requires addition not only of CI substrate (pyruvate+malate or glutamate+malate), but of succinate simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant activity of CII.
+{{MitoPedia
-==References==
+|abbr=NS, CI<small>&</small>II
-*Gnaiger E (2009) Mitochondrial pathways through Complexes I+II: Convergent electron transport at the Q-junction and additive effect of substrate combinations. [http://www.oroboros.at/index.php?compl-12-convergent Mitochondr. Physiol. Network 12.12: 1-20].
+|description='''NS e-input''' or the [[NS-pathway control state]] is electron input from a combination of substrates for the [[N-pathway control state]] and [[S-pathway control state]] through Complexes [[CI]] and [[CII]] simultaneously into the [[Q-junction]]. NS e-input corresponds to [[TCA cycle]] function ''in vivo'', with [[convergent electron flow]] through the [[Electron transfer pathway]]. In [[Mitochondrial preparations|mt-preparations]], NS e-input requires addition not only of NADH- (N-) linked substrates (pyruvate&malate or glutamate&malate), but of succinate (S) simultaneously, since [[metabolite depletion]] in the absence of succinate prevents a significant stimulation of S-linked respiration. For more details, see: [[Additive effect of convergent electron flow]].
-*Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TCH-4W04KR1-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a6456620daa0d8cca022b5f934f2cf30 Int. J. Biochem. Cell Biol. 41: 1837–1845].
+|info=[[Gnaiger 2020 BEC MitoPathways]], [[Gnaiger 2009 Int J Biochem Cell Biol]]
+}}
-{{#set:keyword=Respiration|keyword=Mitochondrial pathways}}
+{{MitoPedia concepts
-{{MitoPedia}}
+|mitopedia concept=MiP concept, SUIT concept
+}}
+== From CI<small>&</small>II e-input to NS e-input ==
+::::» [[Electron_transfer-pathway_state#Terminology:_from_CI-_and_CII-linked_to_N_and_S|Terminology]]