O2k-Publications alert
- Mitochondria and Cell Research - the Oroboros Ecosystem
- Ā» Listed in Oroboros Ecosystem Agenda 2020 Archive
Dec 2020
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Impaired mitochondrial respiration in platelets: A future biomarker for Alzheimerās disease?
- from the O2k-Network Ā»CZ Prague Fisar ZĀ«
- FiÅ”ar Z, JirĆ”k R, ZvÄÅovĆ” M, SetniÄka V, HabartovĆ” L, HroudovĆ” J, VanĆÄkovĆ” Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80. Ā»Bioblast linkĀ«
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Mitotherapy: A promising therapeutic approach for central nervous system damage?
- from the O2k-Network Ā»BR Rio de Janeiro Galina AĀ« and Ā»BR Rio de Janeiro Institute Biomedical ChemistryĀ«
- Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686. Ā»Bioblast linkĀ«
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Is the mitochondrial uncoupler BAM15 the new anti-obesity drug?
- from the O2k-Network Ā»AU Sydney Philp AĀ«
- Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL (2020) Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nat Commun 11:2397. Ā»Bioblast linkĀ«
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Nov 2020
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Antioxidant supplementation: Effects of MitoQ and CoQ10 on ROS production and mitochondrial function
- from the O2k-Network Ā»NZ Auckland Hickey AJĀ«
- Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69. Ā»Bioblast linkĀ«
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HSP60 knockdown and its effect on mitochondriaās role in pancreatic ductal adenocarcinoma
- Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H, Lyu J (2018) Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth. Cell Death Dis 9:161. Ā»Bioblast linkĀ«
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Eight-week high-fat feeding increases mitochondrial ROS production in white adipocytes but mitochondrial respiration remains unaffected.
- from the O2k-Network Ā»CA Guelph Holloway GPĀ«
- Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87. Ā»Bioblast linkĀ«
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Mitochondrial function is impaired in human iPSC-derived astrocytes infected with Zika virus.
- from the O2k-Network Ā»BR Rio de Janeiro Galina AĀ« and Ā»BR Rio de Janeiro Institute Biomedical ChemistryĀ«
- Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218. Ā»Bioblast linkĀ«
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- Nov-14 Sa - World Diabetes Day
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Gastric bypass surgery improves diabetic nephropathy by reducing NADPH production via restoration of AMPK activity in type 1 diabetic rats
- from the O2k-Network Ā»CN Chongqing Zhu ZĀ«
- Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207. Ā»Bioblast linkĀ«
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Six-month caloric restriction causes tissue-specific bioenergetic changes in mitochondria isolated from rat heart and skeletal muscle
- from the O2k-Network Ā»BR Sao Paulo Kowaltowski AJĀ«
- Serna JDC, Caldeira da Silva CC, Kowaltowski AJ (2020) Functional changes induced by caloric restriction in cardiac and skeletal muscle mitochondria. J Bioenerg Biomembr 52:269-77.Ā»Bioblast linkĀ«
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Oct 2020
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Simultaneous measurement of O2 flux and mt-membrane potential: A method to detect deficiency in mitochondrial electron transfer system
- from the O2k-Network Ā»AT Innsbruck OroborosĀ« and Ā»AT Innsbruck Gnaiger EĀ«
- Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81. Ā»Bioblast linkĀ«
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Blood cell respirometry might be an attractive alternative to skeletal- and cardiac muscle-based assessment of mitochondrial function in human studies
- from the O2k-Network Ā»US NC Winston-Salem Molina AJAĀ«
- Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ (2016) Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol 10:65-77.Ā»Bioblast linkĀ«
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Calcium overload: The mechanism by which ER stress leads to Complex I dysfunction?
- from the O2k-Network Ā»US VA Richmond Lesnefsky EJĀ«
- Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced Complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299. Ā»Bioblast linkĀ«
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Childhood maltreatment is associated with increased mitochondrial bioenergetic function of immune cells in mothers, but not in their newborns
- from the O2k-Network Ā»DE Ulm Gumpp AĀ«
- Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-FernĆ”ndez L, Welz T, GĆ¼ndel H, Kolassa IT, Karabatsiakis A (2020) Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A 117:24778-84. Ā»Bioblast linkĀ«
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Fasting promotes functional changes in liver mitochondria: Is it time to reconsider using fasted animals for liver mitochondria isolation?
- from the O2k-Network Ā»BR Sao Paulo Kowaltowski AJĀ«
- Menezes-Filho SL, Amigo I, LuĆ©vano-MartĆnez LA, Kowaltowski AJ (2018) Fasting promotes functional changes in liver mitochondria. Biochim Biophys Acta Bioenerg 1860:129-35. Ā»Bioblast linkĀ«
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Sep 2020
- Sep-29 Tu - World Heart Day
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Succinate dehydrogenase inhibition protects myocardium from ischemia reperfusion injury but efficacy may be influenced by diabetes
- from the O2k-Network Ā»DK Aarhus Boetker HEĀ« and Ā»DK Copenhagen Larsen SĀ«
- Jespersen NR, Hjortbak MV, Lassen TR, StĆøttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, BĆøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344. Ā»Bioblast linkĀ«
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- Sep-21 Mo - World Alzheimer's Day
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Olive polyphenols prove promising in the protection against mitochondrial dysfunction due to Alzheimer's disease and brain aging
- from the O2k-Network Ā»DE Giessen Eckert GPĀ«
- Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248. Ā»Bioblast linkĀ«
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Resistance training effects in Alzheimerās disease mouse model
- from the O2k-Network Ā»US FL Boca Raton Khamoui AVĀ«
- Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501. Ā»Bioblast linkĀ«
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- Sep-15 Tu - World Lymphoma Awareness Day
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OXPHOS as a potential therapeutic target in classical Hodgkin lymphoma
- from the O2k-Network Ā»DE Frankfurt Droese SĀ«, Ā»DE Frankfurt Wittig IĀ« and Ā»NL Nijmegen Brandt UĀ«
- Birkenmeier K, Droese S, Wittig I, Winkelmann R, KƤfer V, Doering C, Hartmann S, Wenz T, Reichert AS, Brandt U, Hansmann ML (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46. Ā»Bioblast linkĀ«
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Alternative oxidase (AOX) can prevent acute hypoxic pulmonary vasoconstriction in mouse lung
- from the O2k-Network Ā»DE Giessen Weissmann NĀ«, Ā»FI Tampere Dufour EĀ«, Ā»FI Helsinki Jacobs HTĀ« and Ā»DE Jena Szibor MĀ«
- Sommer N, Alebrahimdehkordi N, Pak O, Knoepp F, Strielkov I, Scheibe S, Dufour E, Andjelekovic A, Sydykov A, Saraji A, Petrovic A, Quanz K, Hecker M, Kumar M, Wahl J, Kraut S, Seeger W, Schermuly RT, Ghofrani HA, Ramser K, Braun T, Jacobs HT, Weissmann N, Szibor M (2020) Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sci Adv 6:eaba0694. Ā»Bioblast linkĀ«
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A cell-permeable succinate prodrug can alleviate N-methyl carbamate-induced Complex I dysfunction
- from the O2k-Network Ā»US PA Philadelphia Kilbaugh TĀ«, Ā»US PA Philadelphia Jang DHĀ« and Ā»SE Lund Elmer EĀ«
- Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794. Ā»Bioblast linkĀ«
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Aug 2020
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Low-intensity exercise increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults
- from the O2k-Network Ā»LV Riga Makrecka-Kuka MĀ«
- Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489. Ā»Bioblast linkĀ«
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Mitochondrial respiration in PBMCs from patients with major depression
- from the O2k-Network Ā»DE Ulm Karabatsiakis AĀ« and Ā»DE Ulm Radermacher PĀ«
- Karabatsiakis A, Boeck C, Salinas-Manrique J, Kolassa S, Calzia E, Dietrich DE, Kolassa IT (2014) Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Transl Psychiatry 4:e397. Ā»Bioblast linkĀ«
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Mitochondrial respiration in PBMCs: a potential parameter to monitor acute pancreatitis
- from the O2k-Network Ā»NZ Auckland Hickey AJĀ«
- Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR (2016) Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology 16:739-47. Ā»Bioblast linkĀ«
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Ocean warming affects mitochondrial ET capacity in developing eggs of Atlantic herring
- from the O2k-Network Ā»DE Bremerhaven Mark FCĀ«
- Leo E, Dahlke FT, Storch D, Poertner HO, Mark FC (2018) Impact of Ocean Acidification and Warming on the bioenergetics of developing eggs of Atlantic herring Clupea harengus. Conserv Physiol 6:coy050. Ā»Bioblast linkĀ«
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Liver-specific deletion of PARKIN impairs the mitochondrial phosphorylation system
- from the O2k-Network Ā»US PA Pittsburgh Jurczak MJĀ«
- Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab [Epub ahead of print]. Ā»Bioblast linkĀ«
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Jul 2020
- Jul-28 Tu - World Hepatitis Day
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Hepatitis C virus protein expression is related to changes in mitochondrial respiration
- from the O2k-Network Ā»IT Foggia Capitanio NĀ«
- Ripoli M, D'Aprile A, Quarato G, Sarasin-Filipowicz M, Gouttenoire J, Scrima R, Cela O, Boffoli D, Heim MH, Moradpour D, Capitanio N, Piccoli C (2009) Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1Ī±-mediated glycolytic adaptation. J Virol 84:647-60. Ā»Bioblast linkĀ«
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Absence of AMPK in skeletal muscle impacts mitochondrial content and respiration in addition to mitigating glucose intolerance induced by a high-fat diet
- from the O2k-Network Ā»US TN Nashville Wasserman DHĀ« and Ā»US MN Minneapolis Hughey CĀ«
- Lantier L, Williams AS, Williams IM, Guerin A, Bracy DP, Goelzer M, Foretz M, Viollet B, Hughey CC, Wasserman DH (2020) Reciprocity between skeletal muscle AMPK deletion and insulin action in diet-induced obese mice. Diabetes [Epub ahead of print]. Ā»Bioblast linkĀ«
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Alternative oxidase inhibition plays a key role in the aluminum tolerance of cultured Jatropha curcas cells
- from the O2k-Network Ā»BR Ribeirao Preto Alberici LCĀ«
- Vicentini TM, Cavalheiro AH, Dechandt CRP, Alberici LC, Vargas-Rechia CG (2019) Aluminum directly inhibits alternative oxidase pathway and changes metabolic and redox parameters on Jatropha curcas cell culture. Plant Physiol Biochem 136:92-97. Ā»Bioblast linkĀ«
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Influenza A infection induces persistent alterations in whole-body glucose metabolism in mice
- from the O2k-Network Ā»FR Lille Duez HĀ«
- Ayari A, Rosa-Calatrava M, Lancel S, Barthelemy J, Pizzorno A, Mayeuf-Louchart A, Baron M, Hot D, Deruyter L, Soulard D, Julien T, Faveeuw C, Molendi-Coste O, Dombrowicz D, Sedano L, Sencio V, Le Goffic R, Trottein F, Wolowczuk I (2020) Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Commun Biol 3:237. Ā»Bioblast linkĀ«
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Mitochondrial H2O2 flux in cardiac and skeletal muscle preparations is influenced by experimental oxygen concentration
- from the O2k-Network Ā»US CO Fort Collins Chicco AJĀ«
- Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:R972-80. Ā»Bioblast linkĀ«
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Jun 2020
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Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers
- from the O2k-Network Ā»AT Innsbruck Gnaiger EĀ« , Ā»CA Rimouski Blier PUĀ« and Ā»CA Edmonton Lemieux HĀ«
- Lemieux H, Blier PU, Gnaiger E (2017) Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. Ā»Bioblast linkĀ«
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Oxygen consumption by intact platelets positively correlates with the concentration of CoQ10 in the platelets of CKD patients
- from the O2k-Network Ā» SK Bratislava Sumbalova Z Ā«
- GvozdjĆ”kovĆ” A, SumbalovĆ” Z, KucharskĆ” J, KomlĆ³si M, RausovĆ” Z, VanÄovĆ” O, SzĆ”moÅ”ovĆ” M, Mojto V (2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:E176. Ā»Bioblast linkĀ«
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A new potential anti-aging therapeutic target: circadian regulation of mitochondrial uncoupling
- from the O2k-Network Ā»CA Montreal Hepple RTĀ«
- Ulgherait M, Chen A, McAllister SF, Kim HX, Delventhal R, Wayne CR, Garcia CJ, Recinos Y, Oliva M, Canman JC, Picard M, Owusu-Ansah E, Shirasu-Hiza M (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927. Ā»Bioblast linkĀ«
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ASCs-exosomes: a potential therapy to restore mitochondrial function in amyotrophic lateral sclerosis
- from the O2k-Network Ā»IT Verona Calabria EĀ«
- Calabria E, Scambi I, Bonafede R, Schiaffino L, Peroni D, Potrich V, Capelli C, Schena F, Mariotti R (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an in vitro model of ALS. Front Neurosci 13:1070. Ā»Bioblast linkĀ«
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The antidiabetic drug empagliflozin protects cardiac mitochondria against high-fat diet-induced dysfunction in mice
- from the O2k-Network Ā»LV Riga Makrecka-Kuka MĀ«
- Makrecka-Kuka M, Korzh S, Videja M, Vilks K, Cirule H, Kuka J, Dambrova M, Liepinsh E (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther [Epub ahead of print]. Ā»Bioblast linkĀ«
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May 2020
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F1FO-ATP synthase regulates alternative oxidase in Trypanosoma brucei
- from the O2k-Network Ā»BR Sao Paulo Silber AMĀ«
- Alberto LuĆ©vano-MartĆnez L, Girard RMBM, Alencar MB, Silber AM (2020) ATP regulates the activity of an alternative oxidase in Trypanosoma brucei. FEBS Lett [Epub ahead of print]. Ā»Bioblast linkĀ«
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Remodeling of OXPHOS in prostate cancer to potentially damaging mtDNA mutations and differential expression of mt-genes
- from the O2k-Network Ā»AT Innsbruck Gnaiger EĀ« and Ā»AT Innsbruck OroborosĀ«
- Schƶpf B, Weissensteiner H, SchƤfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Giese I, Sorn P, SantāAnna-Silva AC, Iglesias-Gonzalez J, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 11:1487. Ā»Bioblast linkĀ«
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Allergic rhinitis induces mitochondrial dysfunction in peripheral blood cellsĀ«
- from the O2k-Network Ā»Charles Anne-LaureĀ« Ā»Geny BernardĀ«
- Qi S, Barnig C, Charles AL, Poirot A, Meyer A, Clere-Jehl R, de Blay F and Geny Bernard
(2017) Nasal allergen challenge in allergic rhinitis induces mitochondrial dysfunction of peripheral blood mononuclear cells. Ann Allergy Asthma Immunol 10.1016/j.anai.2016.11.026. Ā»Bioblast linkĀ«
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- May-17 Su World Hypertension Day
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Mitochondrial DNA enhances the hypoxia-induced cardioprotective effect in hypertensive rats
- from the O2k-Network Ā»CZ Prague Houstek JĀ« and Ā»CZ Prague Kalous MĀ«
- Neckar J, Svatonova A, Weissova R, Drahota Z, Zajickova P, Brabcova I, Kolar D, Alanova P, Vasinova J, Silhavy J, Hlavackova M, Tauchmannova K, Milerova M, Ostadal B, Cervenka L, Zurmanova J, Kalous M, Novakova O, Novotny J, Pravenec M, Kolar F (2017) Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats. Clin Sci (Lond) 131(9):865-881. Ā»Bioblast linkĀ«
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Restoration of mitochondrial oxygen consumption and decrease of mitochondrial ROS by AOX in the post-ischaemic heart are not sufficient to confer acute or chronic cardioprotection in mouse
- from the O2k-Network Ā» FI Helsinki Jacobs HTĀ« , Ā»DE Magdeburg Gellerich FNĀ« , Ā»FI Tampere Dufour EĀ« , Ā»DE Magdeburg Debska-Vielhaber GĀ« and Ā»DE Frankfurt Wittig IĀ«
- Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gaertner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich Frank N, Schlueter KD, Jacobs HT(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48. Ā»Bioblast linkĀ«
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Mitochondria - a driving force in adipocyte differentiation
- from the O2k-Network Ā»CZ Pilsen Kuncova JĀ«
- KladnickĆ” I, ÄedĆkovĆ” M, KripnerovĆ” M, DvoÅĆ”kovĆ” J, KohoutovĆ” M, TÅÆma Z, MĆ¼llerovĆ” D, KuncovĆ” J (2019) Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue. Physiol Res 68:287-96. Ā»Bioblast linkĀ«
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Expression of alternative oxidase prevents reverse electron transfer formation in heart mitochondria isolated from mouse
- from the O2k-Network Ā»FI Helsinki Jacobs HTĀ« Ā»DE Magdeburg Gellerich FNĀ« Ā»FI Tampere Dufour EĀ« Ā»DE Magdeburg Debska-Vielhaber GĀ« Ā»DE Frankfurt Wittig IĀ« and Ā»UK Brighton Moore ALĀ«
- Szibor M, Gainutdinov T, Fernandez-Vizarra E, Dufour E, Gizatullina Z, Debska-Vielhaber G, Heidler J, Wittig I, Viscomi C, Gellerich FN, Moore AL (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137. Ā»Bioblast linkĀ«
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Apr 2020
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The mitochondrial gas pedal: Cytosolic calcium controls extramitochondrial pyruvate generation and mitochondrial pyruvate uptake
- from the O2k-Network Ā» FI Helsinki Jacobs HT Ā« Ā» DE Magdeburg Gellerich FN Ā« and Ā»DE Magdeburg Debska-Vielhaber GĀ«
- Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, LeĆmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem [Epub ahead of print]. Ā»Bioblast linkĀ«
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The effect of respiration buffer composition on mitochondrial metabolism and function
- from the O2k-Network Ā»US TN Nashville Wasserman DHĀ« and Ā»US MI East Lansing Bazil JNĀ«
- Wollenman LC, Vander Ploeg MR, Miller ML, Zhang Y, Bazil JN (2017) The effect of respiration buffer composition on mitochondrial metabolism and function. PLOS ONE 12:e0187523. - Ā»Bioblast linkĀ«
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Respiratory analysis of coupled mitochondria in cryopreserved liver biopsies
- from the O2k-Network Ā»UY Montevideo Radi RĀ«
- GarcĆa-Roche M, Casal A, Carriquiry M, Radi R, Celia Quijano C, Cassina A (2018) Respiratory analysis of coupled mitochondria in cryopreserved liver biopsies. Redox Biol 17:207-12. - Ā»Bioblast linkĀ«
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Physical activity has positive effects on mitochondria from patients with occupational burnout
- from the O2k-Network Ā»CH Basel Eckert AĀ«
- Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout - an interventional pilot study. J Clin Med 9:E667. - Ā»Bioblast linkĀ«
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Novel diurnal action of of mitochondrial stress-induced GDF15 in systemic metabolism regulation
- from the O2k-Network Ā»DE Nuthetal Klaus SĀ«
- Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep [Epub ahead of print]. - Ā»Bioblast linkĀ«
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Parkinsonās Disease Awareness Month: Dominant mutation in Parkinsonās Disease causes loss of protein function in mitochondria
- from the O2k-Network Ā»FR Angers Gueguen NĀ« and Ā»BE Leuven Spinazzi MĀ«
- Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet [Epub ahead of print]. Ā»Bioblast linkĀ«
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Mar 2020
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High-resolution respirometry in human prostate cancer biopsies and mtDNA analyzed in samples recovered from the O2k-chamber
- from the O2k-Network Ā»AT Innsbruck OroborosĀ«
- Schƶpf Bernd, Weissensteiner Hansi, SchƤfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, SantāAnna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 2020-03-20 [Epub ahead of print]. - Ā»Bioblast linkĀ«
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Multiple Sclerosis Month: Mitochondrial permeability transition pore protection as novel therapeutic approach in multiple sclerosis
- from the O2k-Network Ā»UK London Duchen MRĀ«
- Warne J, Pryce G, Hill J, Shi X, LennerĆ„s F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AW, Towers GJ, Coker A, Duchen MR, Szabadkai G, Baker D, Selwood D (2015) Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis. J Biol Chem 291:4356-73. - Ā»Bioblast linkĀ«
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Muscular exercise for training adipose tissue mitochondria
- from the O2k-Network Ā»DK Copenhagen Larsen SĀ«
- Mendham Amy E, Larsen Steen, George Cindy, Adams Kevin, Hauksson Jon, Olsson Tommy, Fortuin-de Smidt Melony C, Nono Nankam Pamela A, Hakim Olah, Goff Louise M, Pheiffer Carmen, Goedecke Julia H (2020) Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Sci Rep 10:3785. - Ā»Bioblast linkĀ«
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Protein-specific mitochondrial respiratory capacity is higher in women than men
- from the O2k-Network Ā»SE Stockholm Cardinale DAĀ«
- Cardinale DA, Larsen FJ, Schiffer TA, Morales-Alamo D, Ekblom B, Calbet JAL, Holmberg HC, Boushel R (2018) Superior intrinsic mitochondrial respiration in women than in men. Front Physiol 9:1133. - Ā»Bioblast linkĀ«
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Systemic mitochondrial bioenergetics in older adults - skeletal muscle and platelets
- from the O2k-Network Ā»US FL Orlando Goodpaster BHĀ«
- Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248. - Ā»Bioblast linkĀ«
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Rapamycin suppresses senescence in galactose versus glucose cell culture
- from the O2k-Network Ā»US PA Philadelphia Orynbayeva ZĀ«
- Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C (2018) Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. Geroscience 40:243-56. - Ā»Bioblast linkĀ«
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Salty diet, cardiac hypertrophy, calcium overload, and mitochondrial dysfunction
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- Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52. - Ā»Bioblast linkĀ«
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Feb 2020
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Regulation of mitochondrial oxygen kinetics by cytochrome c oxidase
- from the O2k-Network Ā»CZ Prague Houstek JĀ«
- Pajuelo-Reguera David, ÄunĆ”tovĆ” KristĆ½na, VrbackĆ½ Marek, PecinovĆ” Alena, HouÅ”tÄk Josef, MrĆ”Äek TomĆ”Å”, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443. - Ā»Bioblast linkĀ«
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An active lifestyle protects cardiac mitochondria
- from the O2k-Network Ā»KR Busan Han JĀ« - Ā»KR Incheon Kwak HBĀ«
- No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93. - Ā»Bioblast linkĀ«
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Aging and hyperlipidemia impair aortic mitochondrial function and increase the risk of atherosclerosis
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- Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298ā314. - Ā»Bioblast linkĀ«
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Aerobic and resistance training address central defects and peripheral comorbidities in Alzheimerās disease
- from the O2k-Network Ā»US FL Boca Raton Khamoui AVĀ«
- Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Diseases 2020:Article ID 5919501. - Ā»Bioblast linkĀ«
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Blood cell mitochondrial function does not provide a general substitute for muscle biopsies
- from the O2k-Network Ā»US AR Little Rock Boersheim EĀ«
- Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Boersheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. - Ā»Bioblast linkĀ«
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Jan 2020
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Mitochondrial respiration of blood cells and cardiovascular disease
- from the O2k-Network Ā»FR Strasbourg Zoll JĀ«
- Alfatni A, Riou M, Charles AL, Meyer A, Barnig C, Andres E, Lejay A, Talha S, Geny B (2020) Peripheral blood mononuclear cells and platelets mitochondrial dysfunction, oxidative stress, and circulating mtDNA in cardiovascular diseases. J Clin Med 9 pii:E311. - Ā»Bioblast linkĀ«
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Mitochondrial respiration is oxygen-dependent in human cardiac homogenate preparations
- from the O2k-Network Ā»CZ Prague Krajcova AĀ«
- KrajÄovĆ” A, Urban T, Megvinet D, Waldauf P, BalĆk M, HlaviÄka J, Budera P, JanouÅ”ek L, PokornĆ” E, DuÅ”ka F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142. - Ā»Bioblast linkĀ«
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HRR - high-resolution respirometry and oxygen kinetics 10 years ago: Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 2010.
- Ā»Bioblast linkĀ«
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Statistical evaluation on replica in HRR with permeabilized skeletal muscle fibers
- from the O2k-Network Ā»AU Melbourne Stepto NKĀ«
- Jacques M, Kuang J, Bishop DJ, Yan X, Alvarez-Romero J, Munson F, Garnham A, Papadimitriou I, Voisin S, Eynon N (2019) Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study. FASEB J 34:2978-86. - Ā»Bioblast linkĀ«
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