Oxaloacetate: Difference between revisions
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|description=[[File:Oxaloacetic_acid.jpg|left|100px|Oxaloacetic acid]] | |description=[[File:Oxaloacetic_acid.jpg|left|100px|Oxaloacetic acid]] | ||
'''Oxaloacetic acid''', C<sub>4</sub>H<sub>4</sub>O<sub>5</sub>, occurs under physiological conditions as the anion '''oxaloacetate<sup>2-</sup>, Oa'''. | '''Oxaloacetic acid''', C<sub>4</sub>H<sub>4</sub>O<sub>5</sub>, occurs under physiological conditions as the anion '''oxaloacetate<sup>2-</sup>, Oa'''. Oxaloacetate is formed from malate by [[Malate dehydrogenase|MDH]]. Oa reacts with [[acetyl-CoA]] through [[citrate synthase]] to form [[citrate]], or with [[glutamate]] through [[transaminase]] to form [[oxoglutarate]] and [[aspartate]]. Oa transport is restricted across the inner [[mitochondrial|mt]]-membrane of various tissues. Oa is a potent inhibitor of [[succinate dehydrogenase]]. | ||
Oxaloacetate is formed from malate by [[Malate dehydrogenase|MDH]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
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|type=Enzyme | |type=Enzyme | ||
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Revision as of 22:24, 26 July 2014
- high-resolution terminology - matching measurements at high-resolution
Oxaloacetate
Description
Oxaloacetic acid, C4H4O5, occurs under physiological conditions as the anion oxaloacetate2-, Oa. Oxaloacetate is formed from malate by MDH. Oa reacts with acetyl-CoA through citrate synthase to form citrate, or with glutamate through transaminase to form oxoglutarate and aspartate. Oa transport is restricted across the inner mt-membrane of various tissues. Oa is a potent inhibitor of succinate dehydrogenase.
Abbreviation: Oa
Reference: Gnaiger 2014 MitoPathways
MitoPedia topics: Substrate and metabolite
Labels:
Enzyme: TCA Cycle and Matrix Dehydrogenases"TCA Cycle and Matrix Dehydrogenases" is not in the list (Adenine nucleotide translocase, Complex I, Complex II;succinate dehydrogenase, Complex III, Complex IV;cytochrome c oxidase, Complex V;ATP synthase, Inner mt-membrane transporter, Marker enzyme, Supercomplex, TCA cycle and matrix dehydrogenases, ...) of allowed values for the "Enzyme" property. Regulation: Substrate; Glucose; TCA Cycle"Substrate; Glucose; TCA Cycle" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
