PMS-pathway control state

high-resolution terminology - matching measurements at high-resolution

PMS-pathway control state

Description

PMS: Pyruvate & Malate & Succinate.

MitoPathway control: CI&II

Pyruvate (P) is oxidatively decarboxylated to acetyl-CoA and CO₂, yielding NADH catalyzed by pyruvate dehydrogenase. Malate (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009).

Abbreviation: PMS

Reference: Gnaiger 2014 MitoPathways - Chapter 5.5

MitoPedia concepts: SUIT state 

More details

» Additive effect of convergent electron flow

» Respiratory complexes - more than five

» OctPGMSGp pathway control state

» Convergent electron flow

» NS-pathway control state

PMS_L

PMS pathway in the LEAK state can be evaluated in the following SUIT protocols:

PMS_P

PMS pathway in the OXPHOS state can be evaluated in the following SUIT protocols:

PMS_E

PMS pathway in the ET state can be evaluated in the following SUIT protocols:

• SUIT-004

• DL-Protocol for permeabilized fibers (pfi): SUIT-004 O2 pfi D010