Difference between revisions of "PMS-pathway control state"
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{{MitoPedia | {{MitoPedia | ||
|abbr=PMS | |abbr=PMS | ||
|description=[[File:PMS.jpg|left|200px| | |description=[[File:PMS.jpg|left|200px|PMS]]'''PMS''': [[Pyruvate]] & [[Malate]] & [[Succinate]]. | ||
'''MitoPathway control:''' CI&II | '''MitoPathway control:''' CI&II | ||
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[[Pyruvate]] (P) is oxidatively decarboxylated to acetyl-CoA and CO<sub>2</sub>, yielding [[NADH]] catalyzed by pyruvate dehydrogenase. [[Malate]] (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009). | [[Pyruvate]] (P) is oxidatively decarboxylated to acetyl-CoA and CO<sub>2</sub>, yielding [[NADH]] catalyzed by pyruvate dehydrogenase. [[Malate]] (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009). | ||
|info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 5.5]] | |info=[[Gnaiger 2014 MitoPathways |Gnaiger 2014 MitoPathways - Chapter 5.5]] | ||
[[File:PMS.jpg|right|400px|PMS]] | |||
}} | }} | ||
{{MitoPedia concepts | {{MitoPedia concepts | ||
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{{MitoPedia topics}} | {{MitoPedia topics}} | ||
::: ''More details'' | ::: ''More details'' | ||
::::» [[Additive effect of convergent electron flow]] | ::::» [[Additive effect of convergent electron flow]] | ||
Revision as of 16:19, 22 January 2019
- high-resolution terminology - matching measurements at high-resolution
PMS-pathway control state
Description
PMS: Pyruvate & Malate & Succinate.
MitoPathway control: CI&II
Pyruvate (P) is oxidatively decarboxylated to acetyl-CoA and CO2, yielding NADH catalyzed by pyruvate dehydrogenase. Malate (M) is oxidized to oxaloacetate by mt-malate dehydrogenase located in the mitochondrial matrix. Condensation of oxaloacate with acetyl-CoA yields citrate (citrate synthase). This documents an additive effect of convergent CI&II electron flow to the Q-junction, with consistent results obtained with permeabilized muscle fibres and isolated mitochondria (Gnaiger 2009).
Abbreviation: PMS
Reference: Gnaiger 2014 MitoPathways - Chapter 5.5
MitoPedia concepts:
SUIT state
PMSL
PMS pathway in the LEAK state can be evaluated in the following SUIT protocols:
PMSP
PMS pathway in the OXPHOS state can be evaluated in the following SUIT protocols:
PMSE
PMS pathway in the ET state can be evaluated in the following SUIT protocols:
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- DL-Protocol for permeabilized fibers (pfi): SUIT-004 O2 pfi D010
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