Difference between revisions of "Quoilin 2012 Biochem Biophys Res Commun"
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{{Publication | {{Publication | ||
|title=Quoilin C, Mouithys-Mickalad A, Duranteau J, Gallez B, Hoebeke M (2012) Endotoxin-induced basal respiration alterations of renal HK-2 cells: a sign of pathologic metabolism down-regulation. Biochem Biophys Res Commun [Epub ahead of print]. | |title=Quoilin C, Mouithys-Mickalad A, Duranteau J, Gallez B, Hoebeke M (2012) Endotoxin-induced basal respiration alterations of renal HK-2 cells: a sign of pathologic metabolism down-regulation. Biochem Biophys Res Commun [Epub ahead of print]. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed?term=Endotoxin-induced%20basal%20respiration%20alterations%20of%20renal%20HK-2%20cells%3A%20A%20sign%20of%20pathologic%20metabolism%20down-regulation PMID: 22659746] | |info=[http://www.ncbi.nlm.nih.gov/pubmed?term=Endotoxin-induced%20basal%20respiration%20alterations%20of%20renal%20HK-2%20cells%3A%20A%20sign%20of%20pathologic%20metabolism%20down-regulation PMID: 22659746] | ||
|authors=Quoilin C, Mouithys-Mickalad A, Duranteau J, Gallez B, Hoebeke M | |authors=Quoilin C, Mouithys-Mickalad A, Duranteau J, Gallez B, Hoebeke M | ||
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|abstract=To study the mechanism of oxygen regulation in inflammation-induced acute kidney injury, we investigate the effects of a bacterial endotoxin (lipopolysaccharide, LPS) on the basal respiration of proximal tubular epithelial cells (HK-2) both by high-resolution respirometry and electron spin resonance spectroscopy. These two complementary methods have shown that HK-2 cells exhibit a decreased oxygen consumption rate when treated with LPS. Surprisingly, this cellular respiration alteration persists even after the stress factor was removed. We suggested that this irreversible decrease in renal oxygen consumption after LPS challenge is related to a pathologic metabolic down-regulation such as a lack of oxygen utilization by cells. | |abstract=To study the mechanism of oxygen regulation in inflammation-induced acute kidney injury, we investigate the effects of a bacterial endotoxin (lipopolysaccharide, LPS) on the basal respiration of proximal tubular epithelial cells (HK-2) both by high-resolution respirometry and electron spin resonance spectroscopy. These two complementary methods have shown that HK-2 cells exhibit a decreased oxygen consumption rate when treated with LPS. Surprisingly, this cellular respiration alteration persists even after the stress factor was removed. We suggested that this irreversible decrease in renal oxygen consumption after LPS challenge is related to a pathologic metabolic down-regulation such as a lack of oxygen utilization by cells. | ||
|keywords=LPS, HK-2 cells | |keywords=LPS, HK-2 cells | ||
|mipnetlab=BE Liege Votion DM, | |||
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Revision as of 10:48, 8 June 2012
| Quoilin C, Mouithys-Mickalad A, Duranteau J, Gallez B, Hoebeke M (2012) Endotoxin-induced basal respiration alterations of renal HK-2 cells: a sign of pathologic metabolism down-regulation. Biochem Biophys Res Commun [Epub ahead of print]. |
Quoilin C, Mouithys-Mickalad A, Duranteau J, Gallez B, Hoebeke M (2012) Biochem Biophys Res Commun
Abstract: To study the mechanism of oxygen regulation in inflammation-induced acute kidney injury, we investigate the effects of a bacterial endotoxin (lipopolysaccharide, LPS) on the basal respiration of proximal tubular epithelial cells (HK-2) both by high-resolution respirometry and electron spin resonance spectroscopy. These two complementary methods have shown that HK-2 cells exhibit a decreased oxygen consumption rate when treated with LPS. Surprisingly, this cellular respiration alteration persists even after the stress factor was removed. We suggested that this irreversible decrease in renal oxygen consumption after LPS challenge is related to a pathologic metabolic down-regulation such as a lack of oxygen utilization by cells. • Keywords: LPS, HK-2 cells
• O2k-Network Lab: BE Liege Votion DM
Labels:
Tissue;cell: Kidney, Endothelial; Epithelial; Mesothelial Cell"Endothelial; Epithelial; Mesothelial Cell" is not in the list (Heart, Skeletal muscle, Nervous system, Liver, Kidney, Lung;gill, Islet cell;pancreas;thymus, Endothelial;epithelial;mesothelial cell, Blood cells, Fat, ...) of allowed values for the "Tissue and cell" property.
Regulation: Respiration; OXPHOS; ETS Capacity"Respiration; OXPHOS; ETS Capacity" is not in the list (Aerobic glycolysis, ADP, ATP, ATP production, AMP, Calcium, Coupling efficiency;uncoupling, Cyt c, Flux control, Inhibitor, ...) of allowed values for the "Respiration and regulation" property.
HRR: Oxygraph-2k
