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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0AMitochondrial-20dysfunction-20and-20DNA-20damage-20accumulation-20are-20recognised-20hallmarks-20of-20age-20related-20diseases.-20Mitochondrial-20dysfunction-20initiates-20protective-20signalling-20mechanisms-20coordinated-20at-20nuclear-20level-20particularly-20by-20modulating-20transcription-20of-20stress-20signalling-20factors.-20In-20turn,-20the-20cellular-20response-20to-20DNA-20lesions-20comprises-20a-20series-20of-20interconnected-20complex-20protective-20pathways,-20which-20require-20the-20energetic-20and-20metabolic-20support-20of-20the-20mitochondria.-20Here-20I-20will-20discuss-20how-20mitochondria-2Dnucleus-20communication-20operates-20in-20physiologically-20relevant-20stress-20conditions-20to-20protect-20against-20neurodegeneration.-20Thus-20in-20mammalian-20cells-20and-20Drosophila-20subjected-20to-20both-20mitochondrial-20and-20genotoxic-20stress,-20mitochondrial-20activity-20slows-20down-20while-20maintaining-20the-20DNA-20integrity-20takes-20priority.-20Depending-20on-20the-20site-20of-20the-20initiating-20stress,-20mitochondria-20or-20the-20nucleus-20can-20take-20the-20lead-20in-20stress-20response-20initiation-20-2D-20โ€˜talks-20firstโ€™.-20In-20most-20situations-20the-20nucleus-20and-20its-20integrity-20appear-20to-20be-20a-20priority-20-2D-20โ€˜talks-20louderโ€™.-20These-20communication-20phenomena-20have-20a-20protective-20role-20against-20neurodegenerative-20processes." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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