Template:Keywords: Coupling control

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Mitochondrial and cellular respiratory rates in coupling control states

OXPHOS capacity P

ROUTINE respiration R

ET capacity E

LEAK respiration L

Residual oxygen consumption Rox

• Chance and Williams nomenclature: respiratory states

» State 1

» State 2

» State 3

» State 4

» State 5

Flux control ratios related to coupling in mt-preparations and living cells

• L/P coupling control ratio, L/P
• L/R coupling control ratio, L/R
• LEAK-control ratio, L/E
• OXPHOS-control ratio, P/E
• ROUTINE-control ratio, R/E

• Net OXPHOS-control ratio, (P-L)/E
• Net ROUTINE-control ratio, (R-L)/E

Net, excess, and reserve capacities of respiration

• Net OXPHOS-capacity P-L, P-L
• Net ROUTINE-activity R-L, R-L
• Net ET-capacity E-L, E-L
• ET-excess capacity E-P, E-P
• ET-reserve capacity E-R, E-R

Flux control efficiencies related to coupling control ratios

OXPHOS-coupling efficiency P-L, (P-L)/P = 1-L/P

ROUTINE-coupling efficiency R-L, (R-L)/R = 1-L/R

ET-coupling efficiency E-L, (E-L)/E = 1-L/E

ET-excess control efficiency E-P, (E-P)/E = 1-P/E

ET-reserve control efficiency E-R, (E-R)/E = 1-R/E

General

» ET-coupling efficiency

» Flux control efficiency

» Flux control ratio

» Oxidative phosphorylation

» Oxygen flow

» Oxygen flux

» Respiratory acceptor control ratio RCR

» Uncoupling

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  The Blue Book 2020
  

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  OXPHOS-, ROUTINE-, ET-, and LEAK states; respiratory capacities (P, R, E, L) corrected for residual oxygen consumption Rox.

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  4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».

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  (P-L)/P is the OXPHOS P-L control efficiency. The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system when expressed as the E-L coupling efficiency, (E-L)/E. (E-P)/E is the kinetic E-P control efficiency.