Template:Keywords: Coupling control: Difference between revisions
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=== Mitochondrial and cellular respiratory rates in coupling control states === | === Mitochondrial and cellular respiratory rates in coupling control states === | ||
[[Image:OXPHOS-coupled energy cycles.jpg|right|300px||link=Gnaiger 2020 MitoPathways|OXPHOS-coupled energy cycles. Source: The Blue book]] | [[Image:OXPHOS-coupled energy cycles.jpg|right|300px||link=Gnaiger 2020 MitoPathways|OXPHOS-coupled energy cycles. Source: The Blue book]] | ||
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! Name !! Definition !! Icon | |||
|- | |||
| [[OXPHOS-capacity]] || ''P'' = ''P´''-''Rox'' || [[File:P.jpg |link=OXPHOS-capacity]] | |||
|- | |||
| [[ROUTINE-respiration]] || ''R'' = ''R´''-''Rox'' || [[File:R.jpg |link=ROUTINE-respiration]] | |||
|- | |||
| [[ET-capacity]] || ''E'' = ''E´''-''Rox'' || [[File:E.jpg |link=ET-capacity]] | |||
|} | |||
::::::» [[Noncoupled respiration]] - [[Uncoupler]]<ref>Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »[[Uncoupler]]«</ref> | ::::::» [[Noncoupled respiration]] - [[Uncoupler]]<ref>Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »[[Uncoupler]]«</ref> | ||
{| class="wikitable" | |||
|- | |||
| [[LEAK-respiration]] || ''L'' = ''L´''-''Rox'' || [[File:L.jpg |link=LEAK-respiration]] | |||
|} | |||
::::::» [[LEAK-state with ATP]] | ::::::» [[LEAK-state with ATP]] | ||
::::::» [[LEAK-state with oligomycin]] | ::::::» [[LEAK-state with oligomycin]] | ||
::::::» [[LEAK-state without adenylates]] | ::::::» [[LEAK-state without adenylates]] | ||
{| class="wikitable" | |||
|- | |||
| [[Residual oxygen consumption]] ''Rox'' || ''L'' = ''L´''-''Rox'' || [[File:ROX.jpg |link=Residual oxygen consumption]] | |||
|} | |||
:::* Chance and Williams nomenclature: respiratory states | :::* Chance and Williams nomenclature: respiratory states |
Revision as of 18:33, 10 November 2020
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
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Mitochondrial and cellular respiratory rates in coupling control states
Name | Definition | Icon |
---|---|---|
OXPHOS-capacity | P = P´-Rox | |
ROUTINE-respiration | R = R´-Rox | |
ET-capacity | E = E´-Rox |
LEAK-respiration | L = L´-Rox |
Residual oxygen consumption Rox | L = L´-Rox |
- L/P coupling control ratio, L/P
- » Respiratory acceptor control ratio, RCR = P/L
- L/R coupling control ratio, L/R
- L/E coupling control ratio, L/E
- » Uncoupling-control ratio, UCR = E/L
- P/E control ratio, P/E
- R/E control ratio, R/E
- L/P coupling control ratio, L/P
- net P/E control ratio, (P-L)/E
- net R/E control ratio, (R-L)/E
Net, excess, and reserve capacities of respiration
- Net OXPHOS-capacity P-L, P-L
- Net ROUTINE-activity R-L, R-L
- Net ET-capacity E-L, E-L
- ET-excess capacity E-P, E-P
- ET-reserve capacity E-R, E-R
- » Flux control efficiency jZ-Y
- OXPHOS-coupling efficiency P-L, jP-L = (P-L)/P = 1-L/P
- ROUTINE-coupling efficiency R-L, jR-L = (R-L)/R = 1-L/R
- ET-coupling efficiency E-L, jE-L = (E-L)/E = 1-L/E
- ET-excess control efficiency E-P, jE-P = (E-P)/E = 1-P/E
- ET-reserve control efficiency E-R, jE-R = (E-R)/E = 1-R/E
General
- » Background state
- » Basal respiration
- » Baseline state
- » Coupling-control protocol
- » Dyscoupled respiration
- » Dyscoupling
- » Electron leak
- » Electron-transfer-pathway state
- » Level flow
- » Metabolic control variable
- » Oxidative phosphorylation
- » Oxygen flow
- » Oxygen flux
- » Permeabilized cells
- » Phosphorylation system
- » Proton leak
- » Proton slip
- » Reference state
- » Respiratory state
- » Static head
- » Uncoupling