Template:Keywords: Coupling control: Difference between revisions
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=== Mitochondrial and cellular respiratory rates in coupling control states === | === Mitochondrial and cellular respiratory rates in coupling control states === | ||
[[Image:OXPHOS-coupled energy cycles.jpg|right|300px||link=Gnaiger 2020 MitoPathways|OXPHOS-coupled energy cycles. Source: The Blue book]] | [[Image:OXPHOS-coupled energy cycles.jpg|right|300px||link=Gnaiger 2020 MitoPathways|OXPHOS-coupled energy cycles. Source: The Blue book]] | ||
::::» [[Baseline state]] | |||
{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
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| [[ROUTINE-respiration]] || ''R'' = ''R´''-''Rox'' || [[File:R.jpg |link=ROUTINE-respiration]] | | [[ROUTINE-respiration]] || ''R'' = ''R´''-''Rox'' || [[File:R.jpg |link=ROUTINE-respiration]] | ||
|- | |- | ||
| [[ET-capacity]] || ''E'' = ''E´''-''Rox'' || [[File:E.jpg |link=ET-capacity]] || » [[Noncoupled respiration]] - [[Uncoupler]]<ref>Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »[[Uncoupler]]«</ref> | | [[ET-capacity]] || ''E'' = ''E´''-''Rox'' || [[File:E.jpg |link=ET-capacity]] || » [[Level flow]] | ||
|- | |||
| || || || » [[Noncoupled respiration]] - [[Uncoupler]]<ref>Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. »[[Uncoupler]]«</ref> | |||
|- | |||
| [[LEAK-respiration]] || ''L'' = ''L´''-''Rox'' || [[File:L.jpg |link=LEAK-respiration]] || » [[Static head]] | |||
|- | |- | ||
| | | || || || » [[LEAK-state with ATP]] | ||
|- | |- | ||
| || || || » [[LEAK-state with oligomycin]] | | || || || » [[LEAK-state with oligomycin]] | ||
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=== Flux control ratios related to coupling in mt-preparations and living cells === | === Flux control ratios related to coupling in mt-preparations and living cells === | ||
:::» [[Flux control ratio]] | ::::» [[Flux control ratio]] | ||
:::» [[Coupling-control ratio]] | ::::» [[Coupling-control ratio]] | ||
::::» [[Coupling-control protocol]] | |||
{| class="wikitable" | {| class="wikitable" | ||
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=== Net, excess, and reserve capacities of respiration === | === Net, excess, and reserve capacities of respiration === | ||
{| class="wikitable" | |||
|- | |||
! Header text !! Header text !! Header text | |||
|- | |||
| [[Net OXPHOS-capacity P-L |Net OXPHOS-capacity ''P-L'']] || ''P-L'' || [[Image:P-L.jpg|50 px|link=Net OXPHOS-capacity P-L |Net OXPHOS-capacity ''P-L'']] | |||
|- | |||
| [[Net ROUTINE-activity R-L |Net ROUTINE-activity ''R-L'']] || || [[Image:R-L.jpg|50 px|link=Net ROUTINE-activity R-L |Net ROUTINE-activity ''R-L'']] | |||
|- | |||
| [[Net ET-capacity E-L |Net ET-capacity ''E-L'']] || ''E-L'' || [[Image:E-L.jpg|50 px|link=Net ET-capacity E-L |Net ET-capacity ''E-L'']] | |||
|- | |||
| [[ET-excess capacity E-P |ET-excess capacity ''E-P'']] || ''E-P'' || [[Image:ExP.jpg|60 px|link=ET-excess capacity E-P |ET-excess capacity ''E-P'']] | |||
|- | |||
| [[ET-reserve capacity E-R |ET-reserve capacity ''E-R'']] || ''E-R'' | |||
|| [[Image:ExR.jpg|60 px|ET-reserve capacity E-R |ET-reserve capacity ''E-R'']] | |||
|} | |||
=== Flux control efficiencies related to coupling control ratios === | === Flux control efficiencies related to coupling control ratios === | ||
:::» [[Flux control efficiency]] ''j<sub>Z-Y</sub>'' | ::::» [[Flux control efficiency]] ''j<sub>Z-Y</sub>'' | ||
::::» [[Background state]] | |||
:::: [[ | ::::» [[Reference state]] | ||
:::: [[ | ::::» [[Metabolic control variable]] | ||
{| class="wikitable" | |||
|- | |||
! ''j<sub>Z-Y</sub>'' !! !! Definition !! !! Icon | |||
|- | |||
| [[OXPHOS-coupling efficiency P-L |OXPHOS-coupling efficiency ''P-L'']] || ''j<sub>P-L</sub>'' || = (''P-L'')/''P'' || = 1-''L/P'' || [[Image:j--P.jpg|50 px|link=OXPHOS-coupling efficiency P-L |OXPHOS-coupling efficiency ''P-L'']] || » [[Biochemical coupling efficiency]] | |||
|- | |||
| [[ROUTINE-coupling efficiency R-L |ROUTINE-coupling efficiency ''R-L'']] || ''j<sub>R-L</sub>'' || = (''R-L'')/''R'' || = 1-''L/R'' || [[Image:j--R.jpg|50 px|link=ROUTINE-coupling efficiency R-L |ROUTINE-coupling efficiency ''R-L'']] | |||
|- | |||
| [[ET-coupling efficiency E-L |ET-coupling efficiency ''E-L'']] || ''j<sub>E-L</sub>'' || = (''E-L'')/''E'' || = 1-''L/E'' || [[Image:j--E.jpg|50 px|link=ET-coupling efficiency |ET-coupling efficiency ''E-L'']] || » [[Biochemical coupling efficiency]] | |||
|- | |||
| [[ET-excess control efficiency E-P |ET-excess control efficiency ''E-P'']] || ''j<sub>E-P</sub>'' || = (''E-P'')/''E'' || = ''1-''P/E'' || [[Image:jExP.jpg|50 px|link=ET-excess control efficiency E-P |ET-excess control efficiency ''E-P'']] | |||
|- | |||
| [[ET-reserve control efficiency E-R |ET-reserve control efficiency ''E-R'']] || ''j<sub>E-R</sub>'' || = (''E-R'')/''E'' || = 1-''R/E'' || [[Image:jExR.jpg|50 px|link=ET-reserve control efficiency E-R |ET-reserve control efficiency ''E-R'']] | |||
|} | |||
=== General === | === General === | ||
::::» [[Basal respiration]] | ::::» [[Basal respiration]] | ||
::::» [[Dyscoupled respiration]] | ::::» [[Dyscoupled respiration]] | ||
::::» [[Dyscoupling]] | ::::» [[Dyscoupling]] | ||
::::» [[Electron leak]] | ::::» [[Electron leak]] | ||
::::» [[Electron-transfer-pathway state]] | ::::» [[Electron-transfer-pathway state]] | ||
::::» [[Oxidative phosphorylation]] | ::::» [[Oxidative phosphorylation]] | ||
::::» [[Oxygen flow]] | ::::» [[Oxygen flow]] | ||
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::::» [[Proton leak]] | ::::» [[Proton leak]] | ||
::::» [[Proton slip]] | ::::» [[Proton slip]] | ||
::::» [[Respiratory state]] | ::::» [[Respiratory state]] | ||
::::» [[Uncoupling]] | ::::» [[Uncoupling]] | ||
</div> | </div> |
Revision as of 19:17, 10 November 2020
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
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Mitochondrial and cellular respiratory rates in coupling control states
Respiratory rate | Definition | Icon | |
---|---|---|---|
OXPHOS-capacity | P = P´-Rox | ||
ROUTINE-respiration | R = R´-Rox | ||
ET-capacity | E = E´-Rox | » Level flow | |
» Noncoupled respiration - Uncoupler[1] | |||
LEAK-respiration | L = L´-Rox | » Static head | |
» LEAK-state with ATP | |||
» LEAK-state with oligomycin | |||
» LEAK-state without adenylates | |||
Residual oxygen consumption Rox | L = L´-Rox |
FCR | Definition | Icon | |
---|---|---|---|
L/P coupling control ratio | L/P | » Respiratory acceptor control ratio, RCR = P/L | |
L/R coupling control ratio | L/R | ||
L/E coupling control ratio | L/E | » Uncoupling-control ratio, UCR = E/L | |
P/E control ratio | P/E | ||
R/E control ratio | R/E | ||
net P/E control ratio | (P-L)/E | ||
net R/E control ratio | (R-L)/E |
Net, excess, and reserve capacities of respiration
Header text | Header text | Header text |
---|---|---|
Net OXPHOS-capacity P-L | P-L | |
Net ROUTINE-activity R-L | ||
Net ET-capacity E-L | E-L | |
ET-excess capacity E-P | E-P | |
ET-reserve capacity E-R | E-R |
jZ-Y | Definition | Icon | |||
---|---|---|---|---|---|
OXPHOS-coupling efficiency P-L | jP-L | = (P-L)/P | = 1-L/P | » Biochemical coupling efficiency | |
ROUTINE-coupling efficiency R-L | jR-L | = (R-L)/R | = 1-L/R | ||
ET-coupling efficiency E-L | jE-L | = (E-L)/E | = 1-L/E | » Biochemical coupling efficiency | |
ET-excess control efficiency E-P | jE-P | = (E-P)/E | = 1-P/E | ||
ET-reserve control efficiency E-R | jE-R | = (E-R)/E | = 1-R/E |
General