Template:Keywords: Coupling control: Difference between revisions
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Revision as of 23:29, 10 November 2020
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation Pยป (ADP to ATP) without competing with Pยป.
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Mitochondrial and cellular respiratory rates in coupling-control states
Respiratory rate | Definition | Icon | |
---|---|---|---|
OXPHOS-capacity | P = Pยด-Rox | ||
ROUTINE-respiration | R = Rยด-Rox | ||
ET-capacity | E = Eยด-Rox | ยป Level flow | |
ยป Noncoupled respiration - Uncoupler[1] | |||
LEAK-respiration | L = Lยด-Rox | ยป Static head | |
ยป LEAK-state with ATP | |||
ยป LEAK-state with oligomycin | |||
ยป LEAK-state without adenylates | |||
Residual oxygen consumption Rox | L = Lยด-Rox |
FCR | Definition | Icon | |
---|---|---|---|
L/P coupling-control ratio | L/P | ยป Respiratory acceptor control ratio, RCR = P/L | |
L/R coupling-control ratio | L/R | ||
L/E coupling-control ratio | L/E | ยป Uncoupling-control ratio, UCR = E/L | |
P/E control ratio | P/E | ||
R/E control ratio | R/E | ||
net P/E control ratio | (P-L)/E | ||
net R/E control ratio | (R-L)/E |
Net, excess, and reserve capacities of respiration
Respiratory net rate | Definition | Icon |
---|---|---|
Net OXPHOS-capacity P-L | P-L | |
Net ROUTINE-activity R-L | ||
Net ET-capacity E-L | E-L | |
ET-excess capacity E-P | E-P | |
ET-reserve capacity E-R | E-R |
- ยป Flux-control efficiency jZ-Y
- ยป Background state
- ยป Reference state
- ยป Metabolic control variable
Coupling-control efficiency | Definition | Icon | |||
---|---|---|---|---|---|
OXPHOS-coupling efficiency P-L | jP-L | = (P-L)/P | = 1-L/P | ยป Biochemical coupling efficiency | |
ROUTINE-coupling efficiency R-L | jR-L | = (R-L)/R | = 1-L/R | ||
ET-coupling efficiency E-L | jE-L | = (E-L)/E | = 1-L/E | ยป Biochemical coupling efficiency | |
ET-excess control efficiency E-P | jE-P | = (E-P)/E | = 1-P/E | ||
ET-reserve control efficiency E-R | jE-R | = (E-R)/E | = 1-R/E |
General