Template:Keywords: Coupling control
From Bioblast
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
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Mitochondrial and cellular respiratory rates in coupling control states
Respiratory rate | Definition | Icon | |
---|---|---|---|
OXPHOS-capacity | P = P´-Rox | ||
ROUTINE-respiration | R = R´-Rox | ||
ET-capacity | E = E´-Rox | » Noncoupled respiration - Uncoupler[1] | |
LEAK-respiration | L = L´-Rox | » LEAK-state with ATP | |
» LEAK-state with oligomycin | |||
» LEAK-state without adenylates | |||
Residual oxygen consumption Rox | L = L´-Rox |
FCR | Definition | Icon | |
---|---|---|---|
L/P coupling control ratio | L/P | » Respiratory acceptor control ratio, RCR = P/L | |
L/R coupling control ratio | L/R | ||
L/E coupling control ratio | L/E | » Uncoupling-control ratio, UCR = E/L | |
P/E control ratio | P/E | ||
R/E control ratio | R/E | ||
net P/E control ratio | (P-L)/E | ||
net R/E control ratio | (R-L)/E |
Net, excess, and reserve capacities of respiration
- Net OXPHOS-capacity P-L, P-L
- Net ROUTINE-activity R-L, R-L
- Net ET-capacity E-L, E-L
- ET-excess capacity E-P, E-P
- ET-reserve capacity E-R, E-R
- » Flux control efficiency jZ-Y
- OXPHOS-coupling efficiency P-L, jP-L = (P-L)/P = 1-L/P
- ROUTINE-coupling efficiency R-L, jR-L = (R-L)/R = 1-L/R
- ET-coupling efficiency E-L, jE-L = (E-L)/E = 1-L/E
- ET-excess control efficiency E-P, jE-P = (E-P)/E = 1-P/E
- ET-reserve control efficiency E-R, jE-R = (E-R)/E = 1-R/E
General
- » Background state
- » Basal respiration
- » Baseline state
- » Coupling-control protocol
- » Dyscoupled respiration
- » Dyscoupling
- » Electron leak
- » Electron-transfer-pathway state
- » Level flow
- » Metabolic control variable
- » Oxidative phosphorylation
- » Oxygen flow
- » Oxygen flux
- » Permeabilized cells
- » Phosphorylation system
- » Proton leak
- » Proton slip
- » Reference state
- » Respiratory state
- » Static head
- » Uncoupling