- high-resolution terminology - matching measurements at high-resolution
Coupling-control ratio
Description
[[Description::Coupling control ratios, CCR, are flux control ratios, FCR, at a constant mitochondrial substrate state. In mitochondrial preparations, there are three well-defined coupling states of respiration, L, P, E (LEAK, OXPHOS, ETS). In intact cells, state P cannot be induced, but a ROUTINE state of respiration, R, can be measured. The reference state, Jref, is defined by taking Jref as the maximum flux, i.e. flux in the ETS state, E, such that the lower and upper limits of CCR are defined as 0.0 and 1.0. Then there are two mitochondrial CCR, L/E and P/E, and two CCR for intact cells, L/E and R/E.]]
Abbreviation: CCR
Reference: [[Info::Gnaiger_2009_IJBCB, Pesta_2011_Protocols]]
MitoPedia methods:
Respirometry
MitoPedia topics:
Respiratory state
