E-L coupling efficiency: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|abbr=''j<sub>E-L</sub> | |abbr=''j<sub>E-L</sub> | ||
|description=The ''' | |description=The '''ETS coupling efficiency''' is a normalized flux ratio ('[[biochemical coupling efficiency]]') or ''E-L'' coupling control factor, ''j<sub>βE</sub>'' = ''βE/E'' = (''E-L'')/''E'' = 1-''L/E''.Β ''j<sub>βE</sub>'' is 0.0 at zero coupling (''L''=''E'') and 1.0 at the limit of a fully coupled system (''L''=0). The [[LEAK]] state is stimulated to [[ETS]] by [[uncoupler]] titration. LEAK states ''L''<sub>N</sub> or ''L''<sub>T</sub> may be stimulated first by saturating ADP (state ''P'') with subsequent uncoupler titration to state ''E''. The ETS coupling efficiency is based on measurement of the [[coupling control ratio]], ''L/E'', whereas the thermodynamic or [[ergodynamic efficiency]] of coupling between ATP production (DT phosphorylation) and oxygen consumption is based on measurement of the output/input flux ratio (P/O<sub>2</sub> ratio) and output/input force ratio (Gibbs force of phosphorylation/Gibbs force of oxidation). | ||
Β» [[Biochemical_coupling_efficiency#Biochemical_coupling_efficiency:_from_0_to_.3C1 | '''MiPNet article''']] | Β» [[Biochemical_coupling_efficiency#Biochemical_coupling_efficiency:_from_0_to_.3C1 | '''MiPNet article''']] | ||
|info=[[Flux control factor]] | |info=[[Flux control factor]] |
Revision as of 21:19, 25 August 2014
Description
The ETS coupling efficiency is a normalized flux ratio ('biochemical coupling efficiency') or E-L coupling control factor, jβE = βE/E = (E-L)/E = 1-L/E. jβE is 0.0 at zero coupling (L=E) and 1.0 at the limit of a fully coupled system (L=0). The LEAK state is stimulated to ETS by uncoupler titration. LEAK states LN or LT may be stimulated first by saturating ADP (state P) with subsequent uncoupler titration to state E. The ETS coupling efficiency is based on measurement of the coupling control ratio, L/E, whereas the thermodynamic or ergodynamic efficiency of coupling between ATP production (DT phosphorylation) and oxygen consumption is based on measurement of the output/input flux ratio (P/O2 ratio) and output/input force ratio (Gibbs force of phosphorylation/Gibbs force of oxidation). Β» MiPNet article
Abbreviation: jE-L
Reference: Flux control factor
MitoPedia methods:
Respirometry
MitoPedia topics: "Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Respiratory control ratio"Respiratory control ratio" is not in the list (Enzyme, Medium, Inhibitor, Substrate and metabolite, Uncoupler, Sample preparation, Permeabilization agent, EAGLE, MitoGlobal Organizations, MitoGlobal Centres, ...) of allowed values for the "MitoPedia topic" property.
Biochemical coupling efficiency: from 0 to <1
Gnaiger E (2014) Biochemical coupling efficiency: from 0 to <1. Mitochondr Physiol Network 2014-04-18. |
Abstract: Zooming in on biochemical coupling efficiency.
β’ O2k-Network Lab: AT Innsbruck Gnaiger E
Labels:
Regulation: Coupling efficiency;uncoupling
Coupling state: LEAK, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property.
HRR: Theory
Related terms in MitoPedia
Efficiency
Coupling
- Is respiration uncoupled - noncoupled - dyscoupled? [3]
Coupling control factors
- Coupling control factor
- E-L coupling control factor
- E-P coupling control factor
- E-R coupling control factor
Coupling control ratios
- Coupling control ratio
- LEAK control ratio per E
- Phosphorylation system control ratio
- Respiratory acceptor control ratio
Relevant respiratory states
Basics
References
- β Gnaiger E (1993) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65: 1983-2002. Β»Open Access
- β Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving Hypoxia: Mechanisms of Control and Adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo: 77-109. Β»Bioblast Access
- β Gnaiger E. Is respiration uncoupled - noncoupled - dyscoupled? Mitochondr Physiol Network. Β»Uncoupler
- β Gnaiger E (2012) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 3rd ed. Mitochondr Physiol Network 17.18. OROBOROS MiPNet Publications, Innsbruck: 64 pp. Β»Open Access